SYNTHESIS AND IN VITRO ANTIMYCOBACTERIAL EVALUATION OF SOME MOLECULAR HYBRIDS OF 1,3, 4 OXADIAZOLE AND PYRROLE TARGETING CELL WALL SYNTHESIS INHIBITION.
Keywords:
Molecular hybrid of pyrrole with oxadiazole, Antitubercular agent, MABA Assay, Molecular docking, Lipinskii rule of 5Abstract
Objective: To enhance the potency on susceptible mycobacterium tuberculosis and create novel derivatives for multi-drug resistance tuberculosis with molecular hybrid of pyrrole with oxadiazole.
Methods: A number of pyrrole-ligated oxadiazole molecular hybrid derivatives have been developed and produced in response to the bioisosteric similarities between isoniazid and pyrazinamide. FTIR spectral data, mass spectrometry, and NMR were used to identify the target chemicals. The toxicity of the chosen ligands was assessed using human dermal fibroblast cell lines, and the in vitro MABA Assay for antitubercular action of all the prepared compounds against the strain Mycobacterium tuberculosis H37Rv (MTB) was assessed.
Result: Every developed drug exhibited MTB inhibition, with a MIC ranging from 3.25 to 50 μM. OP3 was the most effective MTB inhibitor among the drugs evaluated (MIC = 3.25 μM).
Conclusions: The current study's findings indicate that the majority of the synthesized compounds exhibit an adequate range of molecular characteristics and are sensitive to Mycobacterium TB.
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