ANTI-INFLAMMATORY POTENTIAL EVALUATION AND MORPHOLOGICAL CHARACTERISATION OF NANOHYDROXYAPATITE INCORPORATED GREEN SYNTHESIZED NANOCOMPOSITE- AN IN- VITRO STUDY
Keywords:
Anti-inflammatory, Hydroxyapatite, Green chemistry, Nanocomposites, Nanoparticle.Abstract
Abstract
Objective: This research intended to investigate the anti-inflammatory capabilities of nHAP based nanocomposites developed through green synthesis from citrus fruit peels.
Methods: The experimental design involved the green synthesis of nHAP mediated chitosan-based nanocomposites from Citrus reticulata and Citrus limonum peel extract. The anti-inflammatory potential was assessed using Bovine serum albumin denaturation (BSA) assay, Membrane stabilisation assay (MSA) and Egg albumin denaturation (EA) assays. The developed nanocomposite was also subjected to characterisation using X-ray diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) analysis.
Results: The successful generation of the nanocomposite based on nHAP was carried out. The generated nanocomposite exhibited anti-inflammatory behaviour. The characterisation using XRD and FTIR analysis also confirmed the presence of nHAP particles from the green precursors.
Conclusion: The Citrus reticulata and Citrus limonum peel extract mediated nHAP based nanocomposite exhibited potential anti-inflammatory effects its suggested use in biomedical applications.
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Copyright (c) 2025 Lakshmi Ajithan S, Dhanraj Ganapathy, Rajeshkumar Shanmugham, Arya Nair R, Revathy C V
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