ANTI-INFLAMMATORY POTENTIAL EVALUATION AND MORPHOLOGICAL CHARACTERISATION OF NANOHYDROXYAPATITE INCORPORATED GREEN SYNTHESIZED NANOCOMPOSITE- AN IN-VITRO STUDY

Authors

  • S LAKSHMI AJITHAN Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India https://orcid.org/0000-0002-1976-4591
  • DHANRAJ GANAPATHY Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India
  • RAJESHKUMAR SHANMUGAM Department of Anatomy, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India
  • R ARYA NAIR Department of Prosthodontics, Sri Sankara Dental College, Thiruvananthapuram, Kerala, India
  • C V REVATHY Department of Prosthodontics, Sri Sankara Dental College, Thiruvananthapuram, Kerala, India

DOI:

https://doi.org/10.22159/ajpcr.2026v19i1.57166

Keywords:

Anti-inflammatory, Hydroxyapatite, Green chemistry, Nanocomposites, Nanoparticle.

Abstract

Objective: This research intended to investigate the anti-inflammatory capabilities of nano-hydroxyapatite (nHAP) based nanocomposites developed through green synthesis from citrus fruit peels.

Methods: The experimental design involved the green synthesis of nHAP-mediated chitosan-based nanocomposites from Citrus reticulata and Citrus limonum peel extract. The anti-inflammatory potential was assessed using the Bovine serum albumin (BSA) denaturation assay, membrane stabilization assay and Egg albumin denaturation assays. The developed nanocomposite was also subjected to characterization using X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy analysis.

Results: The successful generation of the nanocomposite based on nHAP was carried out. The generated nanocomposite exhibited anti-inflammatory behavior. The characterization using XRD and FTIR analysis also confirmed the presence of nHAP particles from the green precursors.

Conclusion: The C. reticulata and C. limonum peel extract mediated nHAP-based nanocomposite exhibited potential anti-inflammatory effects its suggested use in biomedical applications.

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Published

07-01-2026

How to Cite

S LAKSHMI AJITHAN, et al. “ANTI-INFLAMMATORY POTENTIAL EVALUATION AND MORPHOLOGICAL CHARACTERISATION OF NANOHYDROXYAPATITE INCORPORATED GREEN SYNTHESIZED NANOCOMPOSITE- AN IN-VITRO STUDY”. Asian Journal of Pharmaceutical and Clinical Research, vol. 19, no. 1, Jan. 2026, pp. 219-26, doi:10.22159/ajpcr.2026v19i1.57166.

Issue

Vol 19 Issue 1 January 2026

Section

Original Article(s)

Copyright (c) 2025 Lakshmi Ajithan S, Dhanraj Ganapathy, Rajeshkumar Shanmugham, Arya Nair R, Revathy C V

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