PHYSICOCHEMICAL CHARACTERIZATION AND DISSOLUTION STUDY OF SOLID DISPERSIONS OF ROSUVASTATIN WITH POLYVINYLPYRROLIDONE K30
DOI:
https://doi.org/10.22159/ijap.2026v18i4.50527Keywords:
Rosuvastatin, Spray drying, PVPK30, Aerosil 200, Solid dispersionAbstract
Objective: The objectiveof the present study was to improve the solubility and dissolution rate of poorly water-soluble drug rosuvastatin (RSV).
Methods: Solid dispersions were prepared by using Poly vinyl pyrrolidone K30 (PVPK30) and Aerosil 200 by spray drying method, with different drug: polymer ratio. These formulations were characterized for saturation solubility, infra-red spectroscopy (IR), differential scanning calorimetry (DSC), powder x-ray diffraction (PXRD) and scanning electron microscopy (SEM).
Results: Saturation solubility of pure drug is 1.42±0.07.The aqueous solubility of RSV was favored by the presence of polymer PVPK30. Saturation solubility of SP4 formulation was found to be 89.5µg/ml which is increased compared to the pure drug. This could be due to increased wettability. In contrast to the very slow dissolution rate of pure RSV, spray dried solid dispersions considerably improved the dissolution rate. The dissolution rate of pure RSV is very low that is 24.03±1.7%drug is dissolved in 3 hours. Whereas all Solid dispersions of RSV with PVPK30(SP1 to SP4) significantly enhanced the dissolution rate of RSV. SP4 presented highest drug release 92.93±3.35%. The solid dispersions have increased the dissolution rate by the possible factors like 1) the strong hydrophilic characteristic of PVPK30 that improves the water penetration and the wettability of the hydrophobic RSV and 2) embedded drug particles in polymer bed, which results in absence of crystallinity. These results are confirmed by PXRD, DSC and SEM. IR studies revealed that there is hydrogen bonding formation between RSV and PVPK30.
Conclusion: Solid dispersions of RSV prepared by the spray drying method shows significant potential for enhancing the solubility and bioavailability.
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