DEVELOPMENT AND OPTIMIZATION OF LASER-DRILLED OSMOTICALLY CONTROLLED NIFEDIPINE EXTENDED-RELEASE TABLETS BY RESOLUTION IV 24-1FRACTIONAL FACTORIAL DESIGN
DOI:
https://doi.org/10.22159/ijap.2026v18i3.57691Keywords:
Nifedipine, Tablet, Osmotically controlled, Laser-drilling, Extended release, Factorial designAbstract
Objective: The purpose of this investigation was to create a tablet containing nifedipine for extended-release by laser drilling technique using a resolution IV 24-1 fractional factorial design.
Methods: The extended-release tablet formulation bearing nifedipine was developed by the wet granulation method. The A resolution IV 24-1fractional factorial design was employed to optimize the nifedipine extended-release tablets. The ratio of sodium chloride (NaCl) to polyox water soluble resin (WSR) NEO, the ratio of NaCl to polyox WSR Coagulant LEO in the push layer, the ratio of polymer and plasticizer in extended release (ER) coat, and % weight gain in the extended-release coat were taken as independent variables, and the percentage of drug dissolved was taken as the dependent variable. The resolution IV 24-1 fractional factorial design was utilized to optimize the formulation, which was subsequently assessed for its performance such as mean weight, thickness, hardness, and friability. Finally, optimized laser-drilledtablets were compared with the undrilled nifedipine extended-release tablets for percent drug release.
Results: The mean weight of the optimized formulation was found to be 718 ± 2.5 mg, the mean thickness was measured to be 7.51± 0.2mm, the hardness of the tablet was found to be 130 ± 5 N, tablet friability was measured as 0.9 ± 0.1% and finally the drug release study of tablets having précised orifice shows controlled drug release over a period of time.
Conclusion: The developed nifedipine extended-release formulation demonstrated controlled drug release following laser drilling. The laser-drilled tablets exhibited a sustained release profile over the study period. The results indicate that laser drilling is a feasible approach for modulating drug release from extended-release tablets.
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