EMERGING ROLE OF TRANSDERMAL NANOEMULSIONS AND NANOEMULGELS BASED ON NATURAL OILS WITH MULTIFACETED FUNCTIONS: PROMISING PLATFORM WITH CHALLENGES AND FUTURE PERSPECTIVES
DOI:
https://doi.org/10.22159/ijap.2026v18i4.58258Keywords:
Transdermal, Natural oils, Nanoemulsion, Nanoemulgel, Skin, PermeationAbstract
For more than a decade, transdermal nanoemulsions (NEs) have shown potential in overcoming the barrier properties of the skin and enhancing the percutaneous absorption of many drugs. In the last few years, great attention has been focused on the design of NEs based on natural oils, particularly for the transdermal treatment of various disorders. These oils exhibit multifaceted roles, as they have shown sufficient drug solubilization and permeation enhancement. Moreover, certain essential oils have demonstrated a synergistic effect with certain drugs, whereas others have revealed a remarkable therapeutic outcome when acting alone within the NE. Besides, efforts have been exerted to optimize the performance of these systems by transforming them into nanoemulgels (NEGs) via incorporating them into gelling agents. NEGs provided an easier skin application, a prolonged retention time, and eventually a better transdermal permeability, and most importantly, a more stable system.
Based on the increased interest in the field of phytopharmaceuticals and its potential pharmacological activities, researchers are driven to design suitable systems for the transdermal delivery of these agents. This review article highlights the importance of transdermal NEs and NEGs based on natural oils, being cost-effective and easy to manufacture, with an emphasis on their composition, challenges, and future perspectives.
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