A CASE REPORT OF NADROPARIN INDUCED HYPERKALEMIA

Abstract

ABSTRACT
Nadroparin, a low molecular weight heparin, has prophylactic and therapeutic use in thromboembolic disorder. In a patient with carcinoma ovary
stage 3 B, nadroparin was given prophylactically for deep vein thrombosis (DVT) before and after interval cytoreduction surgery. Nadroparin 0.3 ml
was given subcutaneously once daily for 1 day preoperatively and 8 days postoperatively. Rise in serum potassium was observed on the third postoperative
day
suggestive
of hyperkalemia.
Intravenous
fluids were
given,
and the
drug was
stopped
on the 9
post-operative day and hyperkalemia
resolved after 2 days. Monitoring of serum potassium level is essential when Nadroparin is administered prophylactically for more than 7 days for
DVT. As this case illustrates a causal relationship between nadroparin and hyperkalemia, caution must be exercised with nadroparin.
Keywords: Nadroparin, Hyperkalemia, Thrombosis.
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