LAMOTRIGINE INDUCED DRESS SYNDROME

SAURABH  AGARWAL; Balaji O; Amita Priya d; Mohan A; Meena K

doi:10.22159/ajpcr.2017.v10i9.18876

Authors

SAURABH AGARWAL Post graduate , Department of Pharmacology, Kasturba Medical college , Manipal university , Manipal.
Balaji O Post graduate , Department of Pharmacology, Kasturba Medical college , Manipal university , Manipal.
Amita Priya d Post graduate , Department of Pharmacology, Kasturba Medical college , Manipal university , Manipal.
Mohan A Associate professor , Department of Pharmacology, Kasturba Medical college , Manipal university , Manipal.
Meena K ASSOCIATE PROFESSOR , Department of Internal medicine, Kasturba Medical college , Manipal university , Manipal.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i9.18876

Keywords:

LIVER TOXICITY, SKIN RASH, EIOSINOPHILIA, ADVERSE DRUG REACTION

Abstract

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome, is a type of hypersensitivity reaction, mainly due to anti-epileptic drugs. Lamotrigine is a newer broad spectrum antiepileptic that can be used in both children and adults. Lamotrigine induced DRESS syndrome is a rare case with incidence of 1/1000 to 1/10000. This syndrome manifests as rash, fever, tender lymphadenopathies, hepatitis, and eosinophilia. This case highlights the need for early diagnosis and treatment of such a rare and life threatening event because early detection of the condition leads to early recovery of the patient. Further re-exposure to the drug should be avoided.

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