COMBINATION OF FRANGIPANI (PLUMERIA ALBA) FLOWER ETHANOL EXTRACT AND SEAWEED (ULVA LACTUCA) EXTRACT AS A NATURAL SUNSCREEN CREAM

PUTU AUSTIN WIDYASARI WIJAYA; MADE PHARMAWATI; NI WAYAN SRI EKAYANTI; LUH GDE EVAYANTI; NI WAYAN DIANA EKAYANI

doi:10.22159/ajpcr.2025v18i3.53746

Authors

PUTU AUSTIN WIDYASARI WIJAYA Department of Physiology and Biochemistry, Faculty of Medicine and Health Science Warmadewa University, Denpasar, Indonesia https://orcid.org/0000-0002-0405-4095
MADE PHARMAWATI Department of Biology, Faculty of Mathematics and Natural Science Udayana University, Badung, Indonesia. https://orcid.org/0000-0002-3064-4582
NI WAYAN SRI EKAYANTI Department of Physiology and Biochemistry, Faculty of Medicine and Health Science Warmadewa University, Denpasar, Indonesia https://orcid.org/0009-0001-0721-9000
LUH GDE EVAYANTI Department of Anatomy and Histology, Faculty of Medicine and Health Science Warmadewa University, Denpasar, Indonesia https://orcid.org/0009-0009-2681-353X
NI WAYAN DIANA EKAYANI Department of Medical Education, Faculty of Medicine and Health Science Warmadewa University, Denpasar, Indonesia.

DOI:

https://doi.org/10.22159/ajpcr.2025v18i3.53746

Keywords:

Frangipani flower, Photo-protective, Seaweed, Sun protection factor, Ultraviolet

Abstract

Objective: This study evaluated the potential of frangipani (Plumeria alba) flower extract and seaweed (Ulva lactuca) extracts as natural sunscreen cream.

Methods: An experimental design with a randomized group approach was used, involving five sample groups. The sun protection factor (SPF) value was determined using an ultraviolet (UV)–visible spectrophotometer. Frangipani and seaweed were extracted using ethanol and formulated into a cream.

Results: The combination of 3% frangipani flower extract and 3% seaweed extract resulted in the highest SPF value of 17.6, demonstrating its effectiveness as a protector against UV radiation.

Conclusion: This study concludes that frangipani flower extract and seaweed extract are promising natural ingredients for use as safe, environmentally friendly sunscreens. These findings contribute to the utilization of local natural resources and the development of safer, ingredient-based cosmetic products.

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References

BMKG; 2024. Available from: https://www.bmkg.go.id

Gu Y, Han J, Jiang C, Zhang Y. Biomarkers, oxidative stress and autophagy in skin aging. Ageing Res Rev. 2020 Dec;59:101036. doi: 10.1016/j.arr.2020.101036, PMID: 32105850

Portilho L, Aiello LM, Vasques LI, Bagatin E, Leonardi GR. Effectiveness of sunscreens and factors influencing sun protection: A review. Braz J Pharm Sci. 2022;58:e20693. doi: 10.1590/s2175- 97902022e20693

Boyd A, Martin S, Legge A, Blewett TA. Are UV filters better together? A comparison of the toxicity of individual ultraviolet filters and off-the-shelf sunscreens to Daphnia magna. Environ Pollut. 2024 Dec;362:124953. doi: 10.1016/j.envpol.2024.124953, PMID: 39277128

He H, Li A, Li S, Tang J, Li L, Xiong L. Natural components in sunscreens: Topical formulations with Sun Protection Factor (SPF). Biomed Pharmacother. 2021 Dec;134:111161. doi: 10.1016/j. biopha.2020.111161, PMID: 33360043

Milito A, Castellano I, Damiani E. From sea to skin: Is there a future for natural photoprotectants? Mar Drugs. 2021;19(7):379. doi: 10.3390/ md19070379, PMID: 34209059

Milutinov J, Pavlović N, Ćirin D, Atanacković Krstonošić M, Krstonošić V. The potential of natural compounds in UV protection products. Molecules. 2024 Nov;29(22):5409. doi: 10.3390/ molecules29225409, PMID: 39598798

Gupta A, Singh AP, Singh VK, Singh PR, Jaiswal J, Kumari N, et al. Natural sun-screening compounds and DNA-repair enzymes: Photoprotection and photoaging. Catalysts. 2023;13(4):745. doi: 10.3390/catal13040745.

Sundari LP, Wijaya PA. Sea lettuce (Ulva lactuca) as a source of dietary antioxidant. Trop J Nat Prod Res. 2021 Apr 01;5(4):603-8. doi: 10.26538/tjnpr/v5i4.1

Pappou S, Dardavila MM, Savvidou MG, Louli V, Magoulas K, Voutsas E. Extraction of bioactive compounds from Ulva lactuca. Appl Sci. 2022;12(4):2117. doi: 10.3390/app12042117

López-Hortas L, Flórez-Fernández N, Torres MD, Ferreira-Anta T, Casas MP, Balboa EM, et al. Applying seaweed compounds in cosmetics, cosmeceuticals and nutricosmetics. Mar Drugs. 2021;19(10):552. doi: 10.3390/md19100552, PMID: 34677451

Ferdosi MF, Kaleem Naseem MK, Afzal A, Haider Khan IH, Javaid A. Potential antimicrobial compounds in flower extract of Plumeria alba. Arab J Chem. 2023;16(6):104719. doi: 10.1016/j.arabjc.2023.104719

Mary Mawumenyo Mamattah KM, Kusiwaa Adomako A, Nketia Mensah C, Borquaye LS. Chemical characterization, antioxidant, antimicrobial, and antibiofilm activities of essential oils of Plumeria alba (forget-me-not). Biochem Res Int. 2023;2023:1040478. doi: 10.1155/2023/1040478, PMID: 36873255

Rudrappa M, Rudayni HA, Assiri RA, Bepari A, Basavarajappa DS, Nagaraja SK, et al. Plumeria alba-mediated green synthesis of silver nanoparticles exhibits antimicrobial effect and anti-oncogenic activity against glioblastoma U118 MG cancer cell line. Nanomaterials (Basel). 2022;12(3):493. doi: 10.3390/nano12030493, PMID: 35159838

Imran M, Asif M. Morphological, ethnobotanical, pharmacognostical and pharmacological studies on the medicinal plant Plumeria alba linn. (Apocynaceae). Arab J Med Aromat Plants. 2020;6(1):54-84. doi: 10.48347/IMIST.PRSM/ajmap-v6i1.20372

Widyasari Wijaya PA, Wihandani DM, Sundari LP. Prevention of higher triglycerides, malondialdehyde, and fatty liver disease using the ethanolic extract of sea lettuce (Ulva lactuca) in male Wistar Rats (Rattus norvegicus). Curr Res Nutr Food Sci. 2022 Apr;10(1):287-94. doi: 10.12944/CRNFSJ.10.1.23

Ashkenazi DY, Figueroa FL, Korbee N, García-Sánchez M, Vega J, Ben-Valid S, et al. Enhancing bioproducts in seaweeds via sustainable aquaculture: Antioxidant and sun-protection compounds. Mar Drugs. 2022;20(12):767. doi: 10.3390/md20120767, PMID: 36547914

Sulistyowati, Elya B, Nur S, Iswandana R. Formulation, antioxidant, and anti-aging activity of Rubus fraxinifolius Fraction. Int J Appl Pharm. 2024;16(4):121-8. doi: 10.22159/ijap.2024v16i4.51013

Surbakti C, Nasution LR, Rudang SN, Cintya H, Indarti V, Agnes PA, et al. Total phenolic, flavonoid contents and antioxidant activity of standardized extract of Gagatan harimau leaves (Vitis gracilis Bl). Int J Appl Pharm. 2024;16(4):38-43. doi: 10.22159/ijap.2024v16s4.52266

Purohit P, Kataria MK. Phytochemicals screening, antioxidant and antimicrobial activity of Carica papaya leaf extracts. Int J Curr Pharm Res. 2024;16(3):95-8. doi: 10.22159/ijcpr.2024v16i3.4087

Ismail GA, Gheda SF, Abo-Shady AM, Abdel-Karim OH. In vitropotential activity of some seaweeds as antioxidants and inhibitors of diabetic enzymes. Food Sci Technol. 2020;40(3):681-91. doi: 10.1590/ fst.15619

Parikh HS, Singh PK, Tiwari A. Algal biorefinery: Focus on cosmeceuticals. Syst Microbiol Biomanuf. 2024 Oct;4(4):1239-61. doi: 10.1007/s43393-024-00287-3

Sundari LP, Widianti IG, Bulandari MA, Tunas IK. Potential of ethanol extract Ulva lactuca cream in inhibiting tyrosinase enzyme activity as an anti-hyperpigmentation agent in guinea pig (Cavia porcellus) skin exposed to ultraviolet radiation. Biomed Pharmacol J. 2024 Dec;17(4):2527-34. doi: 10.13005/bpj/3045

Rosic N, Thornber C. Biotechnological potential of macroalgae during seasonal blooms for sustainable production of UV-absorbing compounds. Mar Drugs. 2023;21(12):633. doi: 10.3390/md21120633, PMID: 38132954

Sami FJ, Soekamto NH, Firdaus, Latip J. Bioactivity profile of three types of seaweed as an antioxidant, UV-protection as sunscreen and their correlation activity. Food Res. 2021 Feb;5(1):441-7. doi: 10.26656/ fr.2017.5(1).389

Araújo RG, Alcantar-Rivera B, Meléndez-Sánchez ER, Martínez-Prado MA, Sosa-Hernández JE, Iqbal HM, et al. Effects of UV and UV-vis irradiation on the production of microalgae and macroalgae: New alternatives to produce photobioprotectors and biomedical compounds. Molecules. 2022 Aug;27(16):5334. doi: 10.3390/molecules27165334, PMID: 36014571

Soleimani S, Yousefzadi M, Babaei Mahani Nezhad S, Pozharitskaya ON, Shikov AN. Potential of the ethyl acetate fraction of Padina boergesenii as a natural UV filter in sunscreen cream formulation. Life (Basel). 2023 Jan;13(1):239. doi: 10.3390/life13010239, PMID: 36676188

Indrianingsih AW, Windarsih A, Noviana E, Suratno SM, Asari SM, Pratiwi SI. In vitro evaluation of antioxidant, α-glucosidase inhibitor, and antibacterial activities of frangipani flower and the principal component analysis of its constituents. Process Biochem. 2023 Jul;130:347-57. doi: 10.1016/j.procbio.2023.04.025

Lekshmi SG, Sethi S, Pooja BK, Nayak SL, Menaka MM. Ornamental plant extracts: Application in food colouration and packaging, antioxidant, antimicrobial and pharmacological potential-A concise review. Food Chem Adv. 2023 Oct;3:100529. doi: 10.1016/j. focha.2023.100529

Ibrahim ND, Seow LJ, Sekar M, Izzati Mat Rani NN, Lum PT. Ten commonly available medicinal plants in Malaysia with potential sun protection factor and antioxidant properties - a review. Pharmacogn J. 2022;14(2):444-55. doi: 10.5530/pj.2022.14.57

Lingwan M, Pradhan AA, Kushwaha AK, Dar MA, Bhagavatula L, Datta S. Photoprotective role of plant secondary metabolites: Biosynthesis, photoregulation, and prospects of metabolic engineering for enhanced protection under excessive light. Environ Exp Bot. 2023 May;209:105300. doi: 10.1016/j.envexpbot.2023.105300

Antunes F, Mota IF, Fangueiro JF, Lopes G, Pintado M, Costa PS. From sugarcane to skin: Lignin as a multifunctional ingredient for cosmetic application. Int J Biol Macromol. 2023 Dec;234:123592. doi: 10.1016/j. ijbiomac.2023.123592, PMID: 36773873

Chavda VP, Acharya D, Hala V, Daware S, Vora LK. Sunscreens: A comprehensive review with the application of nanotechnology. J Drug Deliv Sci Technol. 2023 Jun;86:104720. doi: 10.1016/j. jddst.2023.104720