ORAL MUCOSITIS INDUCED BY RADIATION/CHEMOTHERAPY; CHALLENGES IN THERAPEUTIC IMPLICATIONS AND FUTURE PROSPECTS
DOI:
https://doi.org/10.22159/ajpcr.2025v18i3.53766Keywords:
Mucosal inflammation, Cancer treatment toxicity, Keratinocyte growth factor, Low-level laser therapy, Treatment-related morbidity, Oral epithelial damageAbstract
Oral mucositis (OM) is a common and debilitating side effect of cancer treatments, primarily chemotherapy and radiotherapy. Inflammation of the oral mucosa leads to various severe outcomes, which affect the quality of life in patients. Sometimes, inhibition of treatment may be necessary, which may lead to insubstantial evasion of cancer therapy. The review article discusses current prevention and management techniques, such as oral hygiene protocols, cryotherapy, low-level laser therapy, and pharmacological interventions, including palifermin. It also comments on the risk factors that include the type of cancer, treatment protocols, and patient-related factors. It finally speaks about the clinical and economic impact of OM in the treatment of cancer and healthcare systems.
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