PHARMACOLOGICAL IMPACT OF RUTIN AND QUERCETIN IN ALCOHOL-INDUCED NEUROPATHY IN RATS

PRASHANT S KUMBHAR; SONALI MANWATKAR; BIMLESH KUMAR; SAMRUDDHI BHIKAJI RAJE; AKANKSHA SUNIL CHAVAN

doi:10.22159/ajpcr.2025v18i5.54114

Authors

PRASHANT S KUMBHAR Department of Pharmacology, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India https://orcid.org/0009-0000-5936-654X
SONALI MANWATKAR Department of Pharmacology, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India. https://orcid.org/0000-0002-3194-3189
BIMLESH KUMAR Department of Pharmacology, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India. https://orcid.org/0000-0001-8072-5172
SAMRUDDHI BHIKAJI RAJE Department of Pharmacology, Ashokrao Mane College of Pharmacy, Kolhapur, Maharashtra, India. https://orcid.org/0009-0008-1971-2047
AKANKSHA SUNIL CHAVAN Department of Pharmacology, Ashokrao Mane College of Pharmacy, Kolhapur, Maharashtra, India. https://orcid.org/0009-0007-0987-3894

DOI:

https://doi.org/10.22159/ajpcr.2025v18i5.54114

Keywords:

Rutin, Quercetin, Neuropathic Pain, Alcoholic Neuropathy, High Fat Diet, Neuropathy

Abstract

Objectives: The purpose of this research study was to assess the effect for the simultaneous administration of quercetin and rutin and their combination in neuropathic pain (NP) caused by alcohol.

Methods: Rats were given ethanol (35% v/v, 10 g/kg, p.o.) for 10 weeks to induce alcoholic NP. Ingested Rutin (100 and 50 mg/kg, p.o.) and Quercetin (40 and 20 mg/kg, p.o.) individually and at their lower doses in combination (50 mg/kg Rutin and 20 mg/kg Quercetin, p.o.) to examine differences in mechanical and thermal hyperalgesia, allodynia, and histopathological parameters. Biochemical measurements of glutathione, thiobarbituric acid reactive species, and protein are used to assess the oxidative stress in alcoholic neuropathy.

Results: The results of the study demonstrated that rats given alcohol for 10 weeks experienced severe mechanical and thermal hyperalgesia, allodynia, and an increased degree of oxidative stress. Lower and greater dosages of both medications alone were used to reduce the symptoms of NP brought on by alcohol. However, simultaneous low-dosage treatment of quercetin and rutin has been proven to significantly improve neurological, histopathological, and metabolic functions when compared to their individual administration. Histopathological studies, which show that nerve regeneration occurs, have provided strong support for the treatment of NP.

Conclusion: Therefore, it is hypothesized that giving quercetin and rutin at the same time may help reduce NP and offer an alternate therapeutic strategy.

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