ADVANCED APPROACHES OF POLYSACCHARIDE FUNCTIONALIZED SILVER NANOPARTICLES IN DENTAL APPLICATIONS: A CRITICAL REVIEW
DOI:
https://doi.org/10.22159/ajpcr.2025v18i4.54126Keywords:
Silver Nanoparticles, Polysaccharide, Dental application, antimicrobial, SynthesisAbstract
Silver nanoparticles (AgNPs) have become an integral part of modern dentistry as they are highly antimicrobial. Recent studies involving green synthesis of AgNPs from polysaccharides have opened up new prospects for enhancing the efficiency and safety of silver nanoparticles. This review aims to explore novel directions with silver nanoparticle-polysaccharide systems through their synthesis, engineering, characterization, and dental applications. The scientific articles published between 2012 and 2024 in different journals were retrieved from PubMed, Scopus, and Google Scholar databases to complete the current review taking the recent articles. The diagrams were prepared manually using online software. This study underscores the potential of polymer-conjugated AgNPs as next-generation antimicrobial agents, offering an additive approach for combating resistant microbial infections. Polysaccharide matrices stabilize AgNPs, optimizing their bioavailability and targeted biofilm disruption. Comparative studies show that AgNP-conjugated systems surpass unmodified counterparts in Streptococcus mutans biofilm elimination and prevention of enamel demineralization through prolonged ion release and augmented mucosal adhesion. Integrating polysaccharide-functionalized AgNPs in dental applications represents a significant advancement, offering enhanced antimicrobial efficacy while mitigating toxicity concerns. Comparative analyses highlight superior antimicrobial activity against Streptococcus mutans compared to unmodified AgNPs. Therefore, future research should focus on exploring natural polysaccharides for standardizing synthesis protocols of polysaccharide-AgNPs hybrids to ensure reproducibility and safety for preventing oral infections and promoting oral health, underscoring the need for rigorous clinical trials to validate their long-term efficacy and safety.
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