IMPACT OF PHYSICAL THERAPY APPROACH IN SUBJECTS WITH POST-DENGUE FATIGUE SYNDROME

Authors

  • RAMESH CHANDRA PATRA Department of Physiotherapy, School of Physiotherapy and Paramedical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • GURLEEN KAUR Department of Physiotherapy, Khalsa College, Amritsar, Punjab, India.
  • GURKIRAT SINGH Department of Physiotherapy, School of Physiotherapy and Paramedical Sciences, Lovely Professional University, Phagwara, Punjab, India

DOI:

https://doi.org/10.22159/ajpcr.2025v18i5.54394

Keywords:

Post-dengue fatigue syndrome, Health-related quality-of-life, Physical therapy, Exercise, Chronic fatigue

Abstract

Objectives: The objective of the study was to study the effectiveness of an innovative exercise regimen in alleviating fatigue and enhancing health-related quality-of-life (HRQoL) in individuals suffering from post-dengue fatigue syndrome (PDFS).

Methods: A randomized controlled trial was conducted, with participants diagnosed with PDFS. The innovative exercise protocol included aerobic exercises, graded exercises, breathing exercises, emotional liberation-breathing, Jacobson exercises, and psycho-neurobics, administered over a 6-week period. Both groups received face-to-face and online interaction and video calls for guidance. The outcome measures were the fatigue severity scale (FSS) and HRQoL, assessed before and after the intervention.

Results: The 6-week rehabilitation program led to significant improvements in both groups, as reflected by reduced fatigue levels, evaluated using the FSS, and enhanced HRQoL components. Notably, the experimental group exhibited more significant improvements in reducing fatigue and six HRQoL components, although no significant improvements were observed in surface fitting and grasshopper components. The innovative exercise protocol, alongside the home-based exercise regimen, demonstrated statistically significant effects on alleviating fatigue and improving HRQoL in PDFS patients.

Conclusion: This research underscores the potential of exercise interventions in managing PDFS, shedding light on the beneficial impact of innovative exercise routines on fatigue and HRQoL in individuals dealing with PDFS. Nonetheless, tailored approaches may be necessary to target specific components of HRQoL, such as social functioning and general health, warranting further investigation in this domain.

Downloads

Download data is not yet available.

References

Umakanth M. Post dengue fatigue syndrome. Int J Curr Med Pharm Res. 2017;3(8):2230-1.

Mustafa Z, Khan HM, Azam M, Sami H, Ali SG, Ahmad I, et al. Insight into the seroepidemiology and dynamics of circulating serotypes of dengue virus over a 4 year period in Western Uttar Pradesh, India. Access Microbiol. 2023 Jun 23;5(6):acmi000567.v4. doi: 10.1099/ acmi.0.000567.v4, PMID: 37424567

Yang X, Quam MB, Zhang T, Sang S. Global burden for dengue and the evolving pattern in the past 30 years. J Travel Med. 2021 Dec 29;28(8):taab146. doi: 10.1093/jtm/taab146, PMID: 34510205

Whitehorn J, Farrar J. Dengue. Br Med Bull. 2010;95:161-73. doi: 10.1093/bmb/ldq019, PMID: 20616106

Khetarpal N, Khanna I. Dengue fever: Causes, complications, and vaccine strategies. J Immunol Res. 2016;2016:6803098. doi: 10.1155/2016/6803098, PMID: 27525287

Umakanth M, Narayanasami E, Suganthan N. Profuse sweating and hot flashes: An unusual presentation of post-dengue fatigue syndrome. Cureus. 2020 Aug 25;12(8):e10024. doi: 10.7759/cureus.10024, PMID: 32983719

Trivedi S, Chakravarty A. Neurological complications of dengue fever. Curr Neurol Neurosci Rep. 2022 Aug;22(8):515-29. doi: 10.1007/ s11910-022-01213-7, PMID: 35727463

Carrington LB, Simmons CP. Human to mosquito transmission of dengue viruses. Front Immunol. 2014 Jun 17;5:290. doi: 10.3389/ fimmu.2014.00290, PMID: 24987394

Ferreira-De-Lima VH, Lima-Camara TN. Natural vertical transmission of dengue virus in Aedes aegypti and Aedes albopictus: A systematic review. Parasit Vectors. 2018;11(1):77. doi: 10.1186/s13071-018-2643- 9, PMID: 29391071

Wei Xiang BW, Saron WA, Stewart JC, Hain A, Walvekar V, Missé D, et al. Dengue virus infection modifies mosquito blood-feeding behavior to increase transmission to the host. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2117589119. doi: 10.1073/pnas.2117589119, PMID: 35012987

Behera SP, Bhardwaj P, Deval H, Srivastava N, Singh R, Misra BR, et al. Co-circulation of all the four dengue virus serotypes during 2018-2019: First report from Eastern Uttar Pradesh, India. PeerJ. 2023 Jan 9;11:e14504. doi: 10.7717/peerj.14504, PMID: 36643644

Duong V, Lambrechts L, Paul RE, Ly S, Lay RS, Long KC, et al. Asymptomatic humans transmit dengue virus to mosquitoes. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14688-93. doi: 10.1073/ pnas.1508114112, PMID: 26553981

Makate N, Ramatlho P, Kgoroebutswe TK, Laycock K, Paganotti GM. Mosquito vector diversity and abundance in Southern Botswana, in a global context of emerging pathogen transmission. J Public Health Afr. 2022 Sep 21;13(3):2029. doi: 10.4081/jphia.2022.2029, PMID: 36277950

Ribeiro CF, Lopes VG, Brasil P, Coelho J, Muniz AG, Nogueira RM. Perinatal transmission of dengue: A report of 7 cases. J Pediatr. 2013 Nov;163(5):1514-6. doi: 10.1016/j.jpeds.2013.06.040, PMID: 23916226.

Peiris S, Izcovich A, Ordunez P, Luciani S, Martinez C, Aldighieri S, et al. Challenges to delivering evidence-based management for long COVID. BMJ Evid Based Med. 2023 Oct;28(5):295-8. doi: 10.1136/ bmjebm-2023-112311, PMID: 37491142

Roy S, Gupta SS, Prajapati S, Muzaffar SN, Agrawal A. Expanded dengue syndrome presenting as intracranial hemorrhage, fever, and rhabdomyolysis: A case report. Cureus. 2023 Jan 26;15(1):e34252. doi: 10.7759/cureus.34252, PMID: 36843708

Gulati K, Pasi R, Gupta A, Ravi KS. Dengue fever presenting with severe myositis-An unusual presentation. J Family Med Prim Care. 2020 Dec 31;9(12):6285-7. doi: 10.4103/jfmpc.jfmpc-1680-20, PMID: 33681080

Jácome FC, Caldas GC, Rasinhas AD, De Almeida AL, De Souza DD, Paulino AC, et al. Immunocompetent mice infected by two lineages of dengue virus Type 2: Observations on the pathology of the lung, heart and skeletal muscle. Microorganisms. 2021 Dec 8;9(12):2536. doi: 10.3390/microorganisms9122536, PMID: 34946137

Tayal A, Kabra SK, Lodha R. Management of dengue: An updated review. Indian J Pediatr. 2023 Feb;90(2):168-77. doi: 10.1007/s12098- 022-04394-8, PMID: 36574088

Vidanapathirana M, Atukorala I. Dengue hemorrhagic fever with bleeding and fluid overload in a patient with active lupus nephritis: A case report of diagnostic and therapeutic challenges. BMC Infect Dis. 2023 Jun 26;23(1):433. doi: 10.1186/s12879-023-08415-5, PMID: 37365496

Wormgoor ME, Rodenburg SC. The evidence base for physiotherapy in myalgic encephalomyelitis/chronic fatigue syndrome when considering post-exertional malaise: A systematic review and narrative synthesis. J Transl Med. 2021 Jan 4;19(1):1. doi: 10.1186/s12967-020-02683-4, PMID: 33397399

Lim EJ, Son CG. Review of case definitions for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). J Transl Med. 2020 Jul 29;18(1):289. doi: 10.1186/s12967-020-02455-0, PMID: 32727489

Bernhoff G, Rasmussen-Barr E, Bunketorp Käll L. A comparison of health-related factors between patients diagnosed with ME/ CFS and patients with a related symptom picture but no ME/ CFS diagnosis: A cross-sectional exploratory study. J Transl Med. 2022 Dec 9;20(1):577. doi: 10.1186/s12967-022-03769-x, PMID: 36494693

Eaton-Fitch N, Johnston SC, Zalewski P, Staines D, Marshall- Gradisnik S. Health-related quality of life in patients with myalgic encephalomyelitis/chronic fatigue syndrome: An Australian cross-sectional study. Qual Life Res. 2020 Jun;29(6):1521-31. doi: 10.1007/ s11136-019-02411-6, PMID: 31970624

Ho RT, Chan JS, Wang CW, Lau BW, So KF, Yuen LP, et al. A randomized controlled trial of qigong exercise on fatigue symptoms, functioning, and telomerase activity in persons with chronic fatigue or chronic fatigue syndrome. Ann Behav Med. 2012 Oct;44(2):160-70. doi: 10.1007/s12160-012-9381-6, PMID: 22736201

Larun L, Odgaard‐Jensen J, Brurberg KG, Chalder T, Dybwad M, Moss‐Morris RE, et al. Exercise therapy for chronic fatigue syndrome (individual patient data). Cochrane Database Syst Rev. 2018 Dec 7;2018(12):CD011040.

Knoop V, Mathot E, Louter F, Beckwee D, Mikton C, Diaz T, et al. Measurement properties of instruments to measure the fatigue domain of vitality capacity in community-dwelling older people: An umbrella review of systematic reviews and meta-analysis. Age Ageing. 2023 Oct 28;52(Suppl 4):iv26-43. doi: 10.1093/ageing/afad140, PMID: 37902527

Larun L, Brurberg KG, Odgaard-Jensen J, Price JR. Exercise therapy for chronic fatigue syndrome. Cochrane Database Syst Rev. 2019 Oct 2;10(10):CD003200. doi: 10.1002/14651858.CD003200. pub8, PMID: 31577366.

Barakou I, Sakalidis KE, Abonie US, Finch T, Hackett KL, Hettinga FJ. Effectiveness of physical activity interventions on reducing perceived fatigue among adults with chronic conditions: A systematic review and meta-analysis of randomised controlled trials. Sci Rep. 2023 Sep 4;13(1):14582. doi: 10.1038/s41598-023-41075-8, PMID: 37666869

Salari N, Khodayari Y, Hosseinian-Far A, Zarei H, Rasoulpoor S, Akbari H, et al. Global prevalence of chronic fatigue syndrome among long COVID-19 patients: A systematic review and meta-analysis. Biopsychosoc Med. 2022 Oct 23;16(1):21. doi: 10.1186/s13030-022- 00250-5, PMID: 36274177

Published

07-05-2025

How to Cite

RAMESH CHANDRA PATRA, et al. “IMPACT OF PHYSICAL THERAPY APPROACH IN SUBJECTS WITH POST-DENGUE FATIGUE SYNDROME”. Asian Journal of Pharmaceutical and Clinical Research, vol. 18, no. 5, May 2025, pp. 193-7, doi:10.22159/ajpcr.2025v18i5.54394.

Issue

Section

Original Article(s)