WHITE CURCUMA EXTRACT (CURCUMA ZEDOARIA [CHRISTM.] ROSCOE) AMELIORATES INSULIN RESISTANCE BY MODULATING LIPID METABOLISM IN HIGH-FAT DIET-INDUCED WISTAR RATS
DOI:
https://doi.org/10.22159/ajpcr.2025v18i6.54511Keywords:
Curcuma zedoaria, Insulin resistance, Diabetes, Homeostasis model assessment of insulin resistance, Fat profileAbstract
Objectives: This study aims to examine the mechanism by which white turmeric extract inhibits insulin resistance in experimental animals.
Methods: Twenty-five male Wistar rats were divided into five groups: Normal control, high-fat diet (HFD), drug control (metformin), and two dose groups of white turmeric extract (200 mg/kg and 400 mg/kg). A HFD was administered for 10 days to induce insulin resistance, except in the normal control group. The drug control and two extract groups received metformin (45 mg/kg), and white turmeric extract (200 mg/kg and 400 mg/kg) for an additional 10 days. Insulin resistance was assessed using fasting blood glucose, insulin levels, homeostasis model assessment of insulin resistance (HOMA-IR) index, fat profiles, and tissue morphology of liver and brain organs.
Results: Rats given 400 mg/kg of white turmeric extract showed significantly lower fasting blood glucose (45.04±9.08 mg/dL), insulin levels (1.58±0.37 mU/L), and HOMA-IR index (0.17±0.02) compared to the HFD group (81.55±13.94 mg/dL, 2.28±0.20 mU/L, and 0.46±0.08, respectively). The extract improved fat profiles and caused morphological changes in liver and brain tissue, with liver cells appearing smaller and nerve cells showing longer axons.
Conclusion: White turmeric extract effectively inhibits insulin resistance by improving fat profiles.
Downloads
References
International Diabetes Federation. International Diabetes Federation IDF Diabetes Atlas. 7th ed. Belgium: International Diabetes Federation; 2015.
Morino K, Petersen KF, Shulman GI. Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes. 2006;55 Suppl 2:S9-15. doi: 10.2337/ db06-S002, PMID 17130651, PMCID PMC2995546
Lobo R, Prabhu KS, Shirwaikar A, Shirwaikar A. Curcuma zedoaria rosc. (White turmeric): A review of its chemical, pharmacological and ethnomedicinal properties. J Pharm Pharmacol. 2009;61:13-21. doi: 10.1211/jpp/61.01.0003, PMID 19126292
Wilson B, Abraham G, Manju VS, Mathew M, Vimala B, Sundaresan S, et al. Antimicrobial activity of Curcuma zedoaria and Curcuma malabarica tubers. J Ethnopharmacol. 2005;99:147-51. doi: 10.1016/j. jep.2005.02.004, PMID 15848035
Ansari MH, Ahmad S. Screening of some medicinal plants for antiamoebic action. Fitoterapia. 1991;62:171-5.
Raghuveer GP, AliMdM ED, Setty RS. Evaluation of anti-ulcer effect of root of Curcuma zedoaria in rats. Indian J Trad Knowl. 2004;2:375-7.
Matsuda H, Ninomiya K, Morikawa T, Yoshikawa M. Inhibitory effect and action mechanism of sesquiterpenes from zedoariaerhizomaon d-galactosamine/lipopolysaccharide-induced liver injury. Bioorg Med Chem Lett. 1998;8(4):339-44. doi: 10.1016/S0960-894X(98)00021-3, PMID 9871681
Saka S, Singh AN, Sharma N. Potential anti-cancer superfoods: A minireview. Int J Curr Pharm Res. 2016;8(3):19-21.
Liu CJ, Chan P, Hsu FL, Chen YJ, Hsieh MH, Lo MY et al. The in vitro inhibitory effects of crude extracts of traditional Chinese herbs on 3- hydroxy-3- methylglutaryl-coenzyme a reductase on vero cells. Am J Chin Med. 2002;30:629-36. doi: 10.1142/s0192415x02000454, PMID 12568290
Rahmatullah M, Azam NK, Pramanik S, Sania RN, Rahman S, Jahan R. Antihyperglycemic activity evaluation of rhizomes of Curcuma zedoaria (christm.) roscoe and fruits Sonneratia caseolaris (L.) Engl. Int J Pharm Tech Res. 2012;4(1):125-9.
Shoha J, Jahan H, Al Mamun A, Hossain MT, Ahmed S, Hosain MM, et al. Antihyperglycemic and antinociceptive effects of Curcuma zedoaria (Christm.) roscoe leaf extract in swiss albino mice. Adv Nat Appl Sci. 2010;5(1):6-8. doi: 10.5281/zenodo.14555966
Handajani J, Narissi DH. The effects of curcuma zedoaria oil on high blood sugar level and gingivitis. Dent J (Majalah Kedokteran Gigi). 2015;48(2):69-73. doi: 10.20473/j.djmkg.v48.i2.p69-73
Cheng-Zhi Y, Ling D, Yan Y. Effects of curcuminon insulin resistance in simple obesity rats. Chin Gen Pract. 2009;14:e28784.
Ai J, Wang N, Yang M, Du ZM, Zhang YC, Yang BF. Development of Wistar rat model of insulin resistance. World J Gastroenterol. 2005;11(24):3675-9. doi: 10.3748/wjg.v11.i24.3675, PMID 15968719, PMCID PMC4316015
Riasari H, Fauzi NI, Anggadiredja K, Hartati R, Sukrasno. In vivo antidiabetic screening of kabau (Archidendronbulbalinum(Jack) I.C Nielsen) seeds. Int J Appl Pharm. 2021;13(4):228-34.
Yadav NK, Mazumder R, Rani A, Kumar A. Current perspectives on using nanoparticles for diabetes management. Int J Appl Pharm. 2024;16(5):38-45. doi: 10.22159/ijap.2024v16i5.51084
Published
How to Cite
Issue
Section
Copyright (c) 2025 Novi Irwan Fauzi
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
