PREVALENCE OF SMALL DENSE LDL IN TYPE 2 DIABETES MELLITUS AND ITS CORRELATION WITH INFLAMMATORY MARKERS: A COMPREHENSIVE STUDY

ANUSH N; SUKHDEEP KUMAR; RIJU MATHEW; PRANAV KUMAR PRABHAKAR

doi:10.22159/ajpcr.2025v18i4.54592

Authors

ANUSH N Department of Medical Laboratory Sciences, School of Allied Medical Science, Lovely Professional University, Phagwara, Punjab, India.
SUKHDEEP KUMAR Department of Medical Laboratory Sciences, School of Allied Medical Science, Lovely Professional University, Phagwara, Punjab, India.
RIJU MATHEW Department of Biochemistry, Believers Church Medical College and Hospital, Thiruvalla, Kerala, India
PRANAV KUMAR PRABHAKAR Department of Biotechnology, School of Engineering and Technology, Nagaland University, Kohima Nagaland, India.

DOI:

https://doi.org/10.22159/ajpcr.2025v18i4.54592

Keywords:

Diabetes, Dyslipidemia, Inflammation, Small dense low-density lipoprotein, Type 2 diabetes mellitus, Cardiovascular

Abstract

Objectives: This research pursues to determine the incidence of elevated levels of sdLDL in T2DM patients and study its association with inflammatory biomarkers, including high-sensitivity C-reactive protein (hsCRP), lipoprotein-associated phospholipase A2 (Lp-PLA2), and red cell distribution width (RDW).

Methods: The study involved 158 participants, comprising both diabetic and non-diabetic individuals, recruited from a tertiary care facility. Blood samples underwent analysis for sdLDL levels using a two-step enzymatic technique. Inflammatory markers were estimated using nephelometry and chemiluminescent immunoassays. SPSS was employed for statistical analysis to establish relationships and significance levels.

Results: Diabetic subjects demonstrated particularly higher sdLDL levels than non-diabetic controls (p < 0.001). A robust positive correlation was identified between sdLDL and hsCRP, Lp-PLA2, and RDW, suggesting a connection between sdLDL and systemic inflammation. Regression analysis further substantiated that elevated inflammatory marker levels were linked to increased sdLDL concentrations.

Conclusion: The outcomes underline the crucial role of sdLDL in diabetic dyslipidemia and its strong relationship to inflammation. Estimation of sdLDL levels along with inflammatory biomarkers may improve cardiovascular risk assessment in diabetic patients. Therapeutic interventions, including lipid-lowering and anti-inflammatory approaches, could possibly reduce sdLDL-induced atherosclerosis.

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