AN OBSERVATIONAL STUDY TO COMPARE THE TWO DOSES OF INTRAVENOUS DEXMEDETOMIDINE ON HEMODYNAMIC RESPONSES DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

DINESH CHAUHAN; PALAV SHAH; AMIT CHAUHAN; SARA MARY THOMAS

doi:10.22159/ajpcr.2025v18i9.55033

Authors

DINESH CHAUHAN Department of Anaesthesiology, Shrimati Bhikhiben Kanjibhai Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, India.
PALAV SHAH Department of Anaesthesiology, Shrimati Bhikhiben Kanjibhai Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, India.
AMIT CHAUHAN Department of Anaesthesiology, Shrimati Bhikhiben Kanjibhai Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, India.
SARA MARY THOMAS Department of Anaesthesiology, Shrimati Bhikhiben Kanjibhai Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, India.

DOI:

https://doi.org/10.22159/ajpcr.2025v18i9.55033

Keywords:

Dexmedetomidine, Endotracheal Intubation, Hemodynamic response, Laryngoscopy

Abstract

Objective: During general anesthesia, laryngoscopy and endotracheal intubation may cause hemodynamic disturbances such as tachycardia and hypertension, which may result in difficulties. Dexmedetomidine, an alpha 2 agonist, has been shown to attenuate these responses. However, the optimal dose for this effect is unclear.

Methods: This observational study consisted of 30 patients undergoing general anesthesia, randomly assigned to 2 groups with 15 patients in each group. Group A received intravenous dexmedetomidine 1 mcg/kg, whereas Group B received 0.5 mcg/kg over 20 min before induction. The study was conducted from August 2023 to December 2023.

Results: The results showed that dexmedetomidine 1 mcg/kg (Group A) provided better hemodynamic stability, with a more significant attenuation of systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) compared to the 0.5 mcg/kg dose (Group B). Group A showed significantly lower SBP at intubation (121.73±4.33 mmHg vs. 129.20±7.81 mmHg, p=0.0031) and at 7 min post-intubation (110.53±5.10 mmHg vs. 119.73±6.23 mmHg, p=0.0001). MAP was also significantly lower in Group A at intubation (92.40±4.23 mmHg vs. 98.53±6.54 mmHg, p=0.0050) and remained significantly different throughout the observation period. Heart rate showed no significant difference between groups (p>0.05).

Conclusion: Dexmedetomidine 1 mcg/kg is a more effective dose for maintaining hemodynamic stability in terms of SBP, DBP, and MAP during laryngoscopy and endotracheal intubation compared to 0.5 mcg/kg. This study suggests that the higher dose is a better option for patients undergoing general anesthesia.

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