FORMULATION AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLET OF KETOROLAC TROMETHAMINE PREPARED USING HPMC K100M AND XANTHAN GUM
DOI:
https://doi.org/10.22159/ajpcr.2026v19i2.56018Keywords:
Ketorolac tromethamine, Hydroxypropylmethylcellulose K 100M, Xanthan gum, Matrix tablet, Release retardantAbstract
Objective: The primary goal of this research was to create and assess the efficacy of ketorolac tromethamine (KT) controlled release matrix tablets formulated with Xanthan gum and polymers, hydroxypropylmethylcellulose (HPMC) K100M.
Methods: A 3×3 factorial design was employed, and the matrix tablets were tested. All of the manufactured tablets met the requirements for hardness, friability, weight fluctuation, medicine content, and thickness.
Results: The optimized formulation (F6, containing 36 mg HPMC K100M and 36 mg Xanthan Gum) showed 97.58% drug release over 24 h, fitting the Korsmeyer–Peppas model (R²=0.9964) with non-Fickian diffusion (n=0.5922). The optimized formulation F6 remained stable under accelerated conditions for 3 months.
Conclusion: The study concluded that KT matrix tablets, particularly batch F6 with equal ratios of HPMC K100M and Xanthan gum, showed optimal drug release (94.52% in 24 h) and excellent stability.
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1. Rajveer C, Rathinaraj BS, Fareedullah M, Bangale GS, Shinde GV. Design and evaluation of ketorolac tromethamine sustained release matrix tablets. Deccan. J Pharm Cosmetol. 2010;1(2):57-71.
2. Genç L, Jalvand E. Preparation and in vitro evaluation of controlled release hydrophilic matrix tablets of ketorolac tromethamine using factorial design. Drug Dev Ind Pharm. 2008;34(8):903-10. doi: 10.1080/03639040802266170, PMID 18686094
3. Brocks DR, Jamali F. Clinical pharmacokinetics of ketorolac tromethamine. Clin Pharmacokinet. 1992;23(6):415-27. doi: 10.2165/00003088-199223060-00003, PMID 1458761
4. Vatsaraj N, Zia H, Needham T. Formulation and optimization of a sustained-release tablet of ketorolac tromethamine. Drug Deliv. 2002;9(3):153-9. doi: 10.1080/10426500290095656, PMID 12396732
5. Rao MR, Ranpise AA, Thanki KC, Borate SG, Parikh GN. Effect of processing and sintering on controlled release wax matrix tablets of ketorolac tromethamine. Indian J Pharm Sci. 2009;71(5):538-44. doi: 10.4103/0250-474X.58188, PMID 20502573
6. Benny IS, Gunasekar V, Ponnusami V. Review on application of xanthan gum in drug delivery. Int J PharmTech Res. 2014;6(4):1322-6.
7. Ramasamy T, Kandhasami UD, Ruttala H, Shanmugam S. Formulation and evaluation of xanthan gum based aceclofenac tablets for colon targeted drug delivery. Braz J Pharm Sci. 2011;47(2):299-311. doi: 10.1590/s1984-82502011000200011
8. Jackson C, Ofoefule S. Use of xanthan gum and EthylCellulose in formulation of metronidazole for colon delivery. J Chem Pharm Res. 2011;3:11-20.
9. Jain S, Yadav SK, Patil UK. Preparation and evaluation of Sustained release matrix tablets of furosemide using natural polymers. Res J Pharm Technol. 2008;1:374-6.
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