ASSOCIATION OF SERUM ADIPONECTIN IN NON-DIABETIC HEALTHY YOUNG ADULT OF FIRST-DEGREE RELATION OF T2DM INDIVIDUALS

HARSHVARDHAN; BHARTI KAWATRA; HARPREET KAUR WALIA

doi:10.22159/ajpcr.2025v18i10.56985

Authors

HARSHVARDHAN Department of Biochemistry, Maharishi Markandeshwar Medical College and Hospital, Solan, Himachal Pradesh, India.
BHARTI KAWATRA Department of Biochemistry, Maharishi Markandeshwar Medical College and Hospital, Solan, Himachal Pradesh, India.
HARPREET KAUR WALIA Department of Biochemistry, Maharishi Markandeshwar Medical College and Hospital, Solan, Himachal Pradesh, India.

DOI:

https://doi.org/10.22159/ajpcr.2025v18i10.56985

Keywords:

Adiponectin, First-degree relation, Type 2 diabetes mellitus

Abstract

Objective: Type 2 diabetes mellitus (T2DM) is a leading metabolic disorder, with 1st-° relation (FDR) of affected individuals exhibiting heightened risk due to genetic and environmental factors. Adiponectin is an adipocyte-derived hormone. It has a central function in regulating metabolism, insulin sensitivity, or secretion. To evaluate how adiponectin is associated in healthy, non-diabetic young adults who are FDR of patients with type 2 diabetes, further adding to our knowledge of adiponectin’s influence on diabetes susceptibility and prevention among these individuals.

Methods: There were 100 healthy FDR of T2DM patients and 100 age- and sex-matched controls without a family history of diabetes. Fasting blood samples were collected for analysis of glucose, lipid profile, and serum adiponectin. During the screening period, anthropometric parameters were analyzed using a standard technique. Measurements were conducted using standard biochemical kits and statistically analyzed using Statistical Package for the Social Sciences 25.

Results: In this research, no significant difference was found between group 1 and group 2 regarding age or lipid profile. FDR exhibited significantly lower adiponectin levels (4.67±1.68 μg/mL) compared to controls (8.65±1.51 μg/mL, p<0.001).

Conclusion: The reduced adiponectin in FDRs suggests early metabolic alterations and supports its utility as an early biomarker for T2DM risk assessment. Monitoring adiponectin concentrations in high-risk individuals could facilitate timely interventions, especially in genetically predisposed populations.

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