EFFICACY OF LOZENGES CONTAINING KEPEL FRUIT (STELECHOCARPUS BURAHOL) EXTRACT FOR CONTROLLING ORAL MALODOR

Authors

  • Abrijanto Soen Bing Herbal Master Study Programme, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.
  • Abdul Mun’im 2Pharmacognosy Laboratory, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.
  • Anton Rahardjo Department of Dental Public Health and Preventive Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia.

DOI:

https://doi.org/10.22159/ijap.2018.v10s1.41

Keywords:

Oral malodor, Halitosis, Volatile sulfur compound, Stelechocarpus burahol, Kepel

Abstract

Objective: The aim of this study was to determine the effect of lozenges containing kepel fruit (Stelechocarpus burahol) in controlling oral malodor.
Methods: This study used crossover randomized control trial design. Each of the 30 research subjects received all three treatments at different
times: Kepel, xylitol, and placebo lozenges. The subjects used lozenges in the morning after breakfast and afternoon after lunch. Examinations of oral
malodor were performed thrice: Immediately after waking up, after breakfast, and after lunch. Measured oral odor variables included organoleptic
score and H2S, CH3SH, and (CH3)2S levels.
Results: Effect of burahol fruit extract lozenges was comparable to that of xylitol gum in reducing the H2S, CH3SH, and (CH3)2S levels and organoleptic
scores of the subjects.
Conclusion: Lozenges containing burahol fruit extract were effective in controlling oral malodor (halitosis).

References

Darusman HS. Indonesian kepel fruit (Stelechocarpus burahol) as oral

deodorant. Res J Med Plant 2012;6:180-8.

Molyneux P. The use of the stable free radical diphenylpicrylhydrazyl

(DPPH) for estimating antioxidant activity. Songklanakarin J Sci

Technol 2004;26:211-9.

Fukui Y, Yaegaki K, Murata T, SatoT, Tanaka T, Imai T, et al. Diurnal

changes in oral malodor among dental-office workers. Int Dent J

;58:159-66.

Ahmadi S, Marino T, Prejano M, Russo N, Toscano M. Antioxidant

properties of the vam3 derivative of resveratrol. Molecules

;23:2446.

Lu JM, Lin PH, Yao Q, Chen C. Chemical and molecular mechanisms

of antioxidants: Experimental approaches and model systems. J Cell

Mol Med 2010;14:840-60.

Khanduja KL, Bhardwaj A. Stable free radical scavenging and

antiperoxidative properties of resveratrol compared in vitro with some

other bioflavonoids. Indian J Biochem Biophys 2003;40:416-22.

Devi NB, Jagetia GC. Free radical scavenging and antioxidant potential

of different extracts of Colocasia gigantea (Blume) Hook. F. In vitro.

Int Res J Pharm 2017;8:72-81.

Mantle D, Wilkins RM, Gok MA. Comparison of antioxidant activity

in commercial Ginkgo biloba preparations. J Altern Complement Med

;9:625-9.

Heo SJ, Kim JP, Jung WK, Lee NH, Kang HS, Jun EM, et al.

Identification of chemical structure and free radical scavenging activity

of diphlorethohydroxycarmalol isolated from a brown alga, Ishige

okamurae. J Microbiol Biotechnol 2008;18:676-81.

Negishi O, Negishi Y, Aoyagi Y, Sugahara T, Ozawa T. Mercaptancapturing

properties of mushrooms. J Agric Food Chem

;49:5509‑14.

Snel J, Burgering M, Smit B, Noordman W, Tangerman A, Winkel AG,

et al. Volatile sulfur compounds in morning breath of human volunteers.

Arch Oral Biol 2011;56:29-34.

Amin A, Radji M, Mun’im A, Rahardjo A, Suryadi H. Halitosis activity

against volatile sulfur compound of methyl mercaptan component from

burahol (Stelechocarpus burahol) fruits extract. Asian J Pharm Clin

Res 2017;10:116-9

Published

20-12-2018

How to Cite

Bing, A. S., Mun’im, A., & Rahardjo, A. (2018). EFFICACY OF LOZENGES CONTAINING KEPEL FRUIT (STELECHOCARPUS BURAHOL) EXTRACT FOR CONTROLLING ORAL MALODOR. International Journal of Applied Pharmaceutics, 10(1), 185–189. https://doi.org/10.22159/ijap.2018.v10s1.41

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Original Article(s)

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