SPRAY DOSAGE FORMS: A PROMISING APPROACH TO SYSTEMIC PHARMACOTHERAPY

Authors

  • LUKOYANOVA S. A. I. M. Sechenov First MSMU of the Ministry of Health of the Russian Federation (Sechenov University), Russia https://orcid.org/0009-0002-3347-1960
  • SENTURIN MICHAIL A. I. M. Sechenov First MSMU of the Ministry of Health of the Russian Federation (Sechenov University), Russia
  • SOLOVIEVA N. L. I. M. Sechenov First MSMU of the Ministry of Health of the Russian Federation (Sechenov University), Russia
  • IVAN IVANOVICH I. M. Sechenov First MSMU of the Ministry of Health of the Russian Federation (Sechenov University), Russia
  • KOZLOVA ZHANNA M. I. M. Sechenov First MSMU of the Ministry of Health of the Russian Federation (Sechenov University), Russia https://orcid.org/0000-0003-1525-732X

DOI:

https://doi.org/10.22159/ijap.2025v17i3.53398

Keywords:

Nasal sprays, Oral sprays, Dosage form

Abstract

This article discusses the development of spray medications as a novel and promising approach in therapy, focusing on their advantages, disadvantages, and potential applications. The main idea highlights the importance of innovative drug delivery systems, such as spray formulations, in modern medicine. The article reviews various studies and evaluates the effectiveness of sprays in systemic therapy, emphasizing their benefits in terms of rapid drug action, reduced side effects, patient compliance, dosing accuracy, and convenience of use. This method has several significant advantages: a fast onset of action; for example, nitroglycerin absorption under the tongue occurs very quickly, with maximum plasma concentration reached within 5–8 min, reduced side effects, and increased patient adherence to treatment. Furthermore, the article explores the different types of sprays, including dosing, nasal, and oral sprays, and their applications in cardiovascular diseases, hypertension, headache, insomnia, and erectile dysfunction. The potential for future innovations in spray technology, such as nanotechnology for enhanced drug delivery, controlled release formulations, and specialized formulations for specific conditions, is also discussed. In conclusion, the article points out the promising prospects for the development of spray medications to optimize therapeutic approaches and improve patient outcomes in a wide range of diseases.

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Published

07-05-2025

How to Cite

S. A., L., MICHAIL A., S., N. L., S., IVANOVICH, I., & ZHANNA M., K. (2025). SPRAY DOSAGE FORMS: A PROMISING APPROACH TO SYSTEMIC PHARMACOTHERAPY. International Journal of Applied Pharmaceutics, 17(3), 112–118. https://doi.org/10.22159/ijap.2025v17i3.53398

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Section

Review Article(s)

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