GLOBAL RESEARCH TRENDS (2011-2025) IN CALCIUM CHANNEL BLOCKER POISONING: A SCOPUS-BASED BIBLIOMETRIC ANALYSIS
DOI:
https://doi.org/10.22159/ijap.2026v18i4.57729Keywords:
Bibliometric, Scopus, Calcium channel blockers, Drug overdose, Poisoning, ToxicityAbstract
Objective: Calcium channel blockers (CCBs) account for a substantial proportion of poisoning-related morbidity and mortality worldwide. This bibliometric study aimed to evaluate global publication patterns, research productivity, and thematic development in Scopus-indexed literature on CCBs poisoning from 2011 to 2025.
Methods: A title-restricted Scopus search identified publications related to CCBs poisoning between 2011 and 2025. Records were screened according to PRISMA 2020 guidelines, refined using Microsoft Excel, and analyzed using the Bibliometrix package (R version 4.5.2). Descriptive bibliometric indicators and Multiple Correspondence Analysis (MCA) were applied to assess research performance and conceptual structure.
Results: A total of 349 publications were included, comprising 322 original articles (92.3%) and 27 reviews (7.7%), representing contributions from 47 countries. The United States led global output (25.8%), followed by China (7.7%) and India (7.4%). Pearson correlation analysis demonstrated no statistically significant linear trend in annual publication output (r = –0.048, p = 0.866), indicating a stable but fluctuating research trajectory over time. Keyword co-occurrence mapping identified dominant thematic clusters centered on acute overdose management, cardiovascular instability, intensive care interventions, and advanced supportive therapies, particularly high-dose insulin euglycemia therapy.
Conclusion: The contemporary Scopus-indexed literature on CCBs poisoning reflects a geographically concentrated yet thematically evolving research landscape. Scientific production remains dominated by a limited number of high-income countries, with restricted international collaboration and underrepresentation of low- and middle-income regions. Strengthening multicenter research initiatives and toxicovigilance systems is essential to improve global inclusivity and evidence-based management of CCBs toxicity.
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