Vol 17, Issue 5 (Sep-Oct), 2025

Published: 07-09-2025

Review Article(s)

FAST-TRACKING DRUG APPROVALS: A SYSTEMATIC REVIEW OF THE US FDA'S EXPEDITED REGULATORY PATHWAYS

PREETHAM NS, SARATH MUNDRA, NEIL MESSIAH LOPES, AKHILESH DUBEY

1-8
TARGETED DRUG DELIVERY THROUGH CRISPR‒CAS9: BRIDGING BIOPHARMACEUTICS AND PHARMACOKINETICS

JUBILEE RAMASAMY, DHARSHINI JAISANKAR, SURUTHI RAMAMOORTHY, DEEPIKA JOTHIBASU, NIRANJANI RAVIKUMAR

9-20
THERAPEUTIC POTENTIAL AND APPLICATIONS OF BIOGLASS: A REVIEW

VADNALA SRAVANI, M. VIDYAVATHI

21-29
THE ROLE OF ΑIIBΒ3 RECEPTORS IN MYOCARDIAL INFARCTION: MECHANISMS AND THERAPEUTIC STRATEGIES

ABU SAFANA BISWAS, GANAVI BETHANAGERE RAMESHA, KAMSAGARA LINGANNA KRISHNA, BHARAT JAYAPRAKASH BYALAHUNASHI, SEEMA MEHDI, SUMAN PATHAK

30-41
ADVANCED FABRICATION AND CHARACTERIZATION OF SILVER NANOPARTICLES USING AI TECHNIQUES

ZAINAB LAFI, SINA MATALQAH, SHERINE ASHA, NISREEN ASHA, HALA MHAIDAT, SARA YOUSEF ASHA

42-51
NEUROPROTECTIVE ROLES OF BDNF AND NGF IN ARSENIC-INDUCED NEUROTOXICITY: MECHANISMS AND THERAPEUTIC IMPLICATIONS

AYUSH CHAURASIA, ZEESHAN ANSARI, G. HEMA, ANJU SINGH, AJAY KUMAR GUPTA

52-63
PECTIN BEADS IN DRUG DELIVERY: EXTRACTION, FORMULATION, AND PHARMACEUTICAL APPLICATIONS

SARAVANAN MUNIYANDY

64-73
COMPARATIVE EVALUATION OF FUSED DEPOSITION MODELING AND STEREOLITHOGRAPHY FOR 3D PRINTING OF PERSONALIZED ORAL DRUG DELIVERY SYSTEMS

HIMANSHU THAKUR, MEENAKSHI PATEL, BHARGAVI MISTRY

74-84
NOVEL APPROACHES IN ETHOSOMAL DRUG DELIVERY: APPLICATION IN DERMATOLOGY AND BEYOND

SIMRAN NEGI, SHALU VERMA, PRAYAG RAJ, ALKA SINGH

85-93
STIMULI-RESPONSIVE DRUG DELIVERY SYSTEMS: EXTENSIVE OVERVIEW

JAGAN SUBRAMANIAN, RUTAMBHARA PADHY, JANA ARUN, VIVEK REDDY MURTHANNAGARI, GANESH GNK

94-106
INTEGRATIVE SYSTEMS BIOLOGY AND MULTI-OMICS APPROACHES IN ALZHEIMER'S DISEASE: BRIDGING BIOMARKERS, NEUROINFLAMMATION, AND PRECISION MEDICINE

JITHIN MATHEW, ANSON SUNNY MAROKY, SIVARANJINI SINDURAJ, ANCHU CHANDRABABU

107-121
TECH-DRIVEN TRUST: THE ROLE OF AI AND EMERGING TECHNOLOGIES IN PHARMACEUTICAL QUALITY ASSURANCE `

PAVALAN KRISHNAN, NAGARAJAN JANAKI SANKARACHARI KRISHNAN, ANAMIKA DEY; SHENTHILNATHAN SIVAKUMAR; SARVESH RAVICHANDRAN, MULLAIADHAVAN BHARATHI

122-131

Original Article(s)

DEVELOPMENT OF A METHOD FOR QUALITY CONTROL OF PEPTIDE DRUGS WITHOUT OPENING THE PRIMARY PACKAGING

OLEG V. LEDENEV, GLEB V. PETROV, ALEXANDER Y. SKRIPNIKOV, ANTON V. SYROESHKIN

132-138
IN VITRO COMPARATIVE EFFECTS OF BIOSIMILAR AND REFERENCE BEVACIZUMAB ON OXIDATIVE STRESS, INFLAMMATION, AND CYTOTOXICITY IN RETINAL PIGMENT EPITHELIAL CELLS

PUSSADEE PAENSUWAN, ROSSUKON KHOTCHARRAT, WANACHAT THONGSUK, KANIN LUANGSAWANG

139-145
QUALITY BY DESIGN (QBD) APPROACH FOR OPTIMIZATION OF MANGIFERIN-LOADED NANOPARTICLES FOR THE SAFE AND EFFECTIVE TREATMENT OF BREAST CANCER

SHIJITH K. V., R. NARAYANA CHARYULU, SARATH CHANDRAN, PRAKASH PATIL, JOBIN JOSE

146-158
DESIGN AND IN SILICO EVALUATION OF PHENOXY ACETAMIDE DERIVATIVES AS POTENTIAL ANTIDIABETIC AGENTS

INDHUMATHI S., S. SREE NITHI, GOBIANANTH, MOHD ABDUL BAQI, N. VENKATHESHAN, GANESH MEENA, KOPPULA JAYANTHI

159-167
A GREENNESS EVALUATED BIOANALYTICAL METHOD FOR QUANTIFICATION OF SPARSENTAN IN RAT PLASMA AND ITS APPLICATION TO PHARMACOKINETIC STUDIES BY LC-MS

KRANTHI YALLA, A. KRISHNAMANJARI PAWAR, KIRAN MANDA

168-180
NANOMICELLAR DISPERSION-BASED APPROACH TO IMPROVE AMISULPRIDE DISSOLUTION: FORMULATION, CHARACTERIZATION, AND IN VITRO RELEASE STUDY

HAIDER HANI HASHIM, SABA ABDULHADI JABER

181-192
OPTIMIZATION OF UHPLC METHOD FOR QUANTIFYING IBRUTINIB AND ITS PROCESS-RELATED IMPURITIES IN API: UTILIZING BOX-BEHNKEN DESIGN

KALPANA KRISHNARAJU, MALARKODI VELRAJ

193-202
MILTEFOSINE LOADED MESOPOROUS ZINC OXIDE NANOPARTICLES TO ENHANCE ORAL BIOAVAILABILITY AND SAFETY PROFILE: A PRETOXICOLOGICAL AND PHARMACOKINETIC STUDY

PARAG GHOSH, SUBAS CHANDRA DINDA, DEBAJIT DEWAN, SUKANTA ROY, DIBYA DAS, SOURAV DAS, ANIRBANDEEP BOSE

203-213
MAXIMIZING THE POTENTIAL OF IBRUTINIB: MULTI-FACTOR OPTIMIZATION AND INTERACTION ANALYSIS FOR IMPROVED NANOBUBBLE FORMULATION AND BIOAVAILABILITY PERFORMANCE

B. VIJAYA LAXMI, D. V. R. N. BHIKSHAPATHI, V. V. RAJESHAM, P. POORNIMA, P. SANDHYA, G. ARJUN

214-226
FORMULATION AND EVALUATION OF DRY POWDER INHALABLE NANOPARTICLES FOR THE TREATMENT OF COVID-19

SAGAR VS, JANAKIRAMAN K., AKHIL, JOYSA RUBY J.

227-237
IMPROVED WOUND HEALING ACTIVITY THROUGH SYNERGISTIC APPROACH OF PUMPKIN SEED OIL AND CURCUMIN LOADED MODEL IN MICROGEL

MARGRET CHANDIRA RAJAPPA, AJITH KANNAN, NAGASUBRAMANIAN VENKATASUBRAMANIAM, LOKESH VENKATACHALAM, SELVARAGAVAN KARNAN, DOMINIC ANTONYSAMY

238-252
FROM ALGORITHMS TO EVIDENCE: ASSESSING ARTIFICIAL INTELLIGENCE CHATBOTS AND DRUG DATABASES FOR DETECTING CARDIO-DIABETIC DRUG INTERACTIONS

AFTAB ALAM, ANUKRITI SARAN, RADHIKA JOSHI, SATHVIK B. SRIDHAR, SWAPNIL SHARMA, SARVESH PALIWAL

253-262
DEVELOPMENT OF REDUCED GRAPHENE OXIDE (RGO) NANOSHEETS FOR ULTRASENSITIVE DETECTION OF A NOVEL CORONA VIRUS SARS-COV-2

DEEPAK V. SAWANT, PRANAV K. KATKAR, ARUNKUMAR PARTHASARATHY, R. K. SHARMA, SHIVAJI KASHTE, C. D. LOKHANDE

263-270
DEVELOPMENT AND OPTIMIZATION OF ORAL LACIDIPINE PROBILOSOMES: A BOX–BEHNKEN DESIGN-BASED STUDY

FARAH AYMAN ALSHANTIR, KHALID KADHEM AL-KINANI

271-284
AN LC–ESI-MS/MS METHOD DEVELOPMENTAND ITS VALIDATIONFOR THE QUANTIFICATION OF PRALSETINIB IN K2EDTA HUMANPLASMA

SUNIL DATTATRAY PAWAR, DEEPAK D. KAYANDE, KOKILA PAWAR, MAZAHAR FAROOQUI, ANIL SHANKARWAR, AMOL DESHPANDE, SUNIL SHANKARWAR

285-291
IDENTIFICATION AND CHARACTERIZATION OF NEW IMPURITIES IN DEXAMETHASONE OPHTHALMIC SUSPENSION

BHUPINDER KUMAR, RAJU MUDHULKAR, SREEDHAR GUNDEKARI, DAMA VENUGOPALA RAO, LAKSHMIPRIYA ANAMALAGUNDAM

292-301
CASE-CONTROL STUDY OF IMMUNOGLOBULINES AND PANCREATIC ENZYME ALTERATIONS IN COVID-19 IRAQI PATIENTS

ZAHRAA MOHAMMED ALI NAJI, LUBNA A. ALZUBAIDI, IHAB I. AL KHALIFA, SHAIMAA M. MOHAMMED

302-307
COLOUR STABILITY OF COMPOSITE RESINS IN THE PRESENCE OF HERBAL TEAS: A SPECTROPHOTOMETRIC STUDY

GOWRISH S., VANDANA SADANANDA, MURTAZA HATIM ZAKIYUDDIN

308-314
PHARMACOKINETICS OF A NEWLY FORMULATED IBUPROFEN TABLET IN ARABIC HEALTHY INDIVIDUALS

DUAA JAAFAR JABER AL-TAMIMI, SABA ABDULHADI JABER, HALAH TALAL SULAIMAN

315-319
DEVELOPMENT AND OPTIMIZATION OF SOLID LIPID NANOPARTICLES OF ERLOTINIB USING DESIGN OF EXPERIMENTS: IN VITRO DRUGRELEASE AND IN VIVO PHARMACOKINETIC STUDIES

CHANDU VAMSHI GANGULA, SEEMA TOMAR, POLI REDDYPAPAGATLA

320-331
QBD-DRIVEN DESIGN OF CALENDULA ESSENTIAL OIL NANOSPONGE TOPICAL GEL FOR ENHANCED ANTIBACTERIAL EFFICACY

R. DHANUSH, K. SUJATHA, C. SOWMYA

332-342
INVESTIGATION OF LEVOMILNACIPRAN NANOSTRUCTURED LIPID CARRIERS FOR CNS DRUG DELIVERY THROUGH INTRANASAL ADMINISTRATION USING RAT MODEL

PARTHIBAN R., MOTHILAL M.

343-351
SLOW-RELEASE DRUG DELIVERY SYSTEM FOR MESOPOROUS SILICA NANOPARTICLES LOADED WITH CELASTROL TO CONTROL ADENOCARCINOMA GASTRIC CELLS

MOHAMMAD TAGHI MORADI, DHIYA ALTEMEMY, LEILA HASHEMI, POORIA MOHAMMADI ARVEJEH, MAJID ASADI-SAMANI, FARIBA HOUSHMAND, PEGAH KHOSRAVIAN

352-360
ANALYTICAL QBD INTEGRATED RP-HPLC METHOD DEVELOPMENT AND OPTIMIZATION FOR HIGH-PRECISION QUANTIFICATION OF IBRUTINIB IN HYBRID NANOCARRIER SYSTEMS

PRAGATHI DEVANAND BANGERA, MAHESHA KEERIKKADU, VAMSHI KRISHNA TIPPAVAJHALA, MAHALAXMI RATHNANAND

361-377
ISOLATION AND EVALUATION OF NATURAL GUM EXUDATES OF LANNEA COROMANDELICA (HOUTT.) MERR. AS NATURAL POLYMERIC BINDER AND DRUG RELEASE REGULATING AGENT IN COMPARISON WITH SYNTHETIC AND SEMISYNTHETIC POLYMERS

V. ANUSHA, M. S. UMASHANKAR

378-390
GREEN SYNTHESIS OF SPIRULINA OIL-BASED NANOVESICLES AS A BIOENHANCER FOR THE INTRANASAL BRAIN TARGETING OF STATINS: CELL LINE STUDY ON HUMAN BRAIN CANCER CELL SNB-75 AND PHARMACOKINETICS ON RATS

MAHMOUD ELTAHAN, DOHA H. ABOU BAKER, HEBA S. ABBAS, REHAB ABDELMONEM, MOHAMED EL-NABARAWI, ALSHAIMAA ATTIA

391-405
QBD-BASED RP-UPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF ATEZOLIZUMAB AND HYALURONIDASE IN CANCER DRUG FORMULATIONS

KONDURI JAYA SREE, RAJU MUDHULKAR, SREEDHAR GUNDEKARI, NAVEEN KUMAR KOTTAKKI, AMRUTHA SRI KONDURI

406-416
BIO-ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF TENELIGLIPTIN, REMOGLIFLOZIN ETABONATE AND ITS APPLICATION TO PHARMACOKINETIC STUDIES IN RAT PLASMA BY USING LC-MS/MS

T. SATYADEV, BHARGAVI CHINTA, MANIKANTA RAKESH VEJJU, B. VICTOR PRADEEP SAGAR

417-425
FORMULATION STRATEGY FOR STABLE POSACONAZOLE NANOEMULSION: APPLICATION OF PSEUDOTERNARY PHASE DIAGRAM IN PREFORMULATION DESIGN

MOHAMMED SADIK HAMZA, ZAINAB THABIT SALEH

426-435
MOLECULAR DOCKING AND ADMET PROPERTIES OF NOVEL 5-METHYL-6AH-BENZO [4, 5] OXAZOLO [3,2-A]QUINOLIN-2-OL DERIVATIVES FOR THEIR ANTI-CANCER ACTIVITY

SIMPI MEHTA, POONAM KASWAN, POOJA RANJAN, SUDESH

436-443
STANDARDIZATION OF AN AYURVEDIC POLYHERBAL LIQUID FORMULATION WITH IMPROVED PALATABILITY FOR THE MANAGEMENT OF ANEMIA

KOPPERUNDEVI RAMACHANDRAN, SHALINI KARUNANITHI, DAMODHARAN NARAYANASAMY

444-453
DESIGN AND EVALUATION OF NEOMYCIN SULFATE-LOADED SOLID LIPID NANOPARTICLES (SLNs) FOR OCULAR ADMINISTRATION

VEEKSHA S. SHETTY, SANDEEP DS

454-464
STABILITY INDICATING LC–ESI-MS/MS METHOD DEVELOPMENT AND VALIDATION FOR THE QUANTITATION OF LURBINECTEDIN IN BIOLOGICAL MATRICES

MANTRAVADI ANUSHA, RAMREDDY GODELA, KUMAR SHIVA GUBBIYAPPA

465-470
HPLC-BASED BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF POSACONAZOLE IN SPIKED RAT PLASMA

INDUJA GOVINDAN, ANJANA A. KAILAS, ABUTWAIBE KA, THAMIZHARASAN ANNADURAI, ANUP NAHA

471-480
COMPUTATIONAL INVESTIGATION OF THE INHIBITION OF CHK1 AND WEE1 PROTEINS BY CHEMICAL CONSTITUENTS OF AMARANTHUS GANGETICUS

ADE S. ROHANI, HENNY S. WAHYUNI, EFFENDY DL PUTRA, NAZLINIWATY, CELINE AULETTA, TIARA RASYIDA

481-487
ENHANCED BIOAVAILABILITY OF LOBEGLITAZONE VIA DISSOLVING MICRONEEDLE PATCHES IN RATS

SUKANTA ROY, BALARAM GHOSH, ANANYA CHANDRA, DIBYA DAS, PARAG GHOSH, SANGEETA CHOUDHURY, ANIRBANDEEP BOSE, SUBAS CHANDRA DINDA

488-498
TRANSMUCOSAL BUCCAL PATCHES CARRYING BENIDIPINE HYDROCHLORIDE WITH A UNIDIRECTIONAL RELEASE OPTIMIZED BY CENTRAL COMPOSITE DESIGN

KUMARA SWAMY SAMANTHULA, CHANDRASHEKAR THALLURI, SATYA OBBALAREDDY, DANIEL KOTHAPALLY, SRIKANTH PAREPALLI

499-509
A NEW RELATED SUBSTANCES METHOD DEVELOPMENT AND VALIDATION OF METRONIDAZOLE AND PREDNISOLONE BY USING EFFECTIVE LIQUID CHROMATOGRAPHIC METHOD

M. MANORANJANI, D. ANITHA, NANDURI GAYATRI DEVI

510-518
PREPARATION AND CHARACTERIZATION OF NOVEL LOXOPROFEN-LOADED SOLID LIPID NANOPARTICLES

TABAREK KHALID HASAN, MAZIN THAMIR ABDUL-HASAN

519-527
PLASMA CONCENTRATION OF CURCUMIN AND SELENIUM FOLLOWING ADMINISTRATION OF SLOW-RELEASE CURCUMIN-LOADED SELENIUM NANOPARTICLES

JAHANGIR KABOUTARI, FATEMEH SABAGHI, DHIYA ALTEMEMY, HOSEIN ALI ARAB, MOOSE JAVDAI, PEGAH KHOSRAVIYAN

528-533
EXPLORATION OF NICOTINOYL HYDRAZINE DERIVATIVES THROUGH IN SILICO STUDIES FOR NOVEL ANTI-TUBERCULAR DRUG DEVELOPMENT

AKASH HR, K. ARCHANA DEVI, S. BELIN, SENTHIL KUMAR P., MOHD ABDUL BAQI, N. VENKATHESHAN, M. SUCHARITHA, KOPPULA JAYANTHI

534-541