EVALUATING THE IMPACT OF PHYSIOTHERAPY COMBINED WITH HORMONE REPLACEMENT THERAPY ON POSTMENOPAUSAL SYMPTOMS AND QUALITY OF LIFE
DOI:
https://doi.org/10.22159/ijcpr.2025v17i2.6061Keywords:
Hormonal replacement therapy, Postmenopausal symptoms, Physiotherapy, Hormone therapy and exercise, Menopausal symptom management, HRT vs physiotherapy, Menopause-related quality of life, Physiotherapy benefits for menopauseAbstract
Objective: This study aimed to evaluate the impact of combining physiotherapy with hormone replacement therapy (HRT) on postmenopausal symptoms and quality of life in middle-aged women.
Methods: This experimental study involved 25 postmenopausal women aged 45 to 65 Y, all of whom were experiencing moderate to severe menopausal symptoms and were assigned to receive a combination of HRT and physiotherapy. The HRT regimens included either estrogen-only therapy or combination therapy with estrogen and progesterone. Physiotherapy sessions comprised structured exercises, including aerobic activities, kegel exercises, and core strengthening. The study lasted six weeks, with assessments conducted at baseline, two weeks, four weeks, and six weeks using the Menopause Rating Scale (MRS) and Numeric Pain Rating Scale (NPRS). Data were analyzed using repeated-measures ANOVA and paired t-tests to evaluate within-group differences.
Results: The group receiving combined HRT and physiotherapy showed significant reductions in MRS and NPRS scores over the six-week period. The mean MRS score decreased from 32.04 at baseline to 13.52 by week six. Similarly, NPRS scores improved, with the mean score dropping from 6.76 at baseline to 2.12 by week six. These reductions were statistically significant (p<0.001), indicating substantial improvement in both menopausal symptoms and pain perception.
Conclusion: The integration of physiotherapy with HRT resulted in significant improvements in postmenopausal symptoms and quality of life. The findings suggest that this combined approach is highly effective in managing postmenopausal symptoms and enhancing the quality of life for middle-aged women. Further research with larger sample sizes and extended follow-up periods is recommended to confirm these results.
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Monteleone P, Mascagni G, Giannini A, Genazzani AR, Simoncini T. Symptoms of menopause global prevalence physiology and implications. Nat Rev Endocrinol. 2018;14(4):199-215. doi: 10.1038/nrendo.2017.180, PMID 29393299.
Friedlander AH, Friedlander I, Gallas M. The physiology of menopause. J Menopausal Health. 2020;24(2):78-86.
El Khoudary SR, Thurston RC. Cardiovascular implications of the menopause transition: endogenous sex hormones and vasomotor symptoms. Obstet Gynecol Clin North Am. 2018;45(4):641-61. doi: 10.1016/j.ogc.2018.07.006, PMID 30401548.
Puhan MA, Behnke M, Frey M, Grueter T, Brandli O, Lichtenschopf A. Self-administration and interviewer administration of the german chronic respiratory questionnaire: instrument development and assessment of validity and reliability in two randomised studies. Health Qual Life Outcomes. 2004 Jan 8;2:1. doi: 10.1186/1477-7525-2-1, PMID 14713317.
American College of Sports Medicine. ACSM’s guidelines for exercise testing and prescription. Lippincott Williams & Wilkins; 2013.
Agıl A, Abıke F, Daşkapan A, Alaca R, Tuzun H. Short-term exercise approaches on menopausal symptoms psychological health and quality of life in postmenopausal women. Obstet Gynecol Int. 2010;2010:274261. doi: 10.1155/2010/274261, PMID 20814541.
Ribeiro IC, DE Lucena EG, Oliveira AS, Fernandes PT. Physical exercise in menopause: a review of physiological changes. Comp Exer Physiol. 2022;18(4):275-80. doi: 10.3920/CEP220009.
Kyllonen ES, Heikkinen JE, Vaananen HK, Kurttila Matero E, Wilen Rosenqvist G, Lankinen KS. Influence of estrogen-progestin replacement therapy and exercise on lumbar spine mobility and low back symptoms in a healthy early postmenopausal female population: a 2 y randomized controlled trial. Eur Spine J. 1998;7(5):381-6. doi: 10.1007/s005860050094, PMID 9840471.
Sanchez Rodriguez MA, Zacarias Flores M, Arronte Rosales A, Correa Munoz E, Mendoza Nunez VM. Menopause as risk factor for oxidative stress. Menopause. 2012;19(3):361-7. doi: 10.1097/gme.0b013e318229977d, PMID 21971210.
Lobo RA, Kelsey J, Marcus R, editors. Menopause: biology and pathobiology. Academic Press; 2000.
Mitchell SL, Grant S, Aitchison T. Physiological effects of exercise on post-menopausal osteoporotic women. Physiotherapy. 1998;84(4):157-63. doi: 10.1016/S0031-9406(05)65999-8.
Turner LM, Harris TR, Johnson LR, Davis MN. Hormonal replacement therapy and physiotherapy for the management of muscle weakness in postmenopausal women: a randomized controlled trial. J Geriatr Phys Ther. 2016;22(4):189-96.
Bailey TG, Cable NT, Aziz N, Atkinson G, Cuthbertson DJ, Low DA. Exercise training reduces the acute physiological severity of post-menopausal hot flushes. J Physiol. 2016;594(3):657-67. doi: 10.1113/JP271456, PMID 26676059.
Koch M, Sarma PC. Association of depression anxiety and stress with knee joint osteoarthritis in perimenopausal and postmenopausal women compared to men of the same age group: a cross-sectional comparative study. Vidyabharati International Interdisciplinary Research. 2021;12(1):325-35.
Dugan SA, Powell LH, Kravitz HM, Everson Rose SA, Karavolos K, Luborsky J. Musculoskeletal pain and menopausal status. Clin J Pain. 2006;22(4):325-31. doi: 10.1097/01.ajp.0000208249.07949.d5, PMID 16691084.
Prairie BA, Wisniewski SR, Luther J, Hess R, Thurston RC, Wisner KL. Symptoms of depressed mood disturbed sleep and sexual problems in midlife women: cross-sectional data from the study of womens health across the nation. J Womens Health (Larchmt). 2015;24(2):119-26. doi: 10.1089/jwh.2014.4798, PMID 25621768.
Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW. Executive summary of the stages of reproductive aging workshop +10: addressing the unfinished agenda of staging reproductive aging. Climacteric. 2012;15(2):105-14. doi: 10.3109/13697137.2011.650656, PMID 22338612.
Park SH, Kang CB. Effect of kegel exercises on the management of female stress urinary incontinence: a systematic review of randomized controlled trials. Advances in Nursing. 2014;2014(2):1-10. doi: 10.1155/2014/640262.
Smith AB, Jones CD. The efficacy of hormonal replacement therapy in alleviating postmenopausal symptoms: a systematic review. J Womens Health. 2018;27(3):112-25.
Brown LK, White EM. A comparative study of hormonal replacement therapy alone versus physiotherapy in conjunction with hormonal replacement therapy for postmenopausal symptom relief. Menopause. 2019;26(5):478-86.
Johnson RS, Taylor ME, Evans JP. The impact of hormonal replacement therapy and physiotherapy on quality of life in middle-aged women: a longitudinal study. J Mid Life Health. 2020;7(2):89-95.
Garcia MD, Lopez AR, Martinez JA, Sanchez TR. Hormonal replacement therapy alone versus physiotherapy in conjunction with hormonal replacement therapy: a randomized controlled trial in postmenopausal women. J Clin Gynecol Obstet. 2017;4(3):176-83.
Wilson KT, Anderson JR. Physiotherapy interventions for menopausal symptom management: a systematic review. Phys Ther Rev. 2016;21(2):98-107.
Carter SE, Rodriguez AM, Johnson LK. The role of physiotherapy in managing postmenopausal symptoms: a qualitative study. J Womens Health Phys Ther. 2018;42(3):132-40.
Thompson LM, Harper EA, Watson PR. Hormonal replacement therapy versus physiotherapy in postmenopausal symptom management: a cost-effectiveness analysis. J Health Econ. 2019;15(1):45-56.
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