ANTIDEPRESSANT AND ANXIOLYTIC ACTIVITY OF FICUS RELIGIOSA ADVENTITIOUS ROOT EXTRACTS IN MICE

GAURAV HASTIR; AJEET PAL SINGH; AMAR PAL SINGH

doi:10.22159/ijcpr.2025v17i4.7010

Authors

GAURAV HASTIR Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R. E. C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar-144011, Punjab, India
AJEET PAL SINGH Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R. E. C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar-144011, Punjab, India
AMAR PAL SINGH Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R. E. C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar-144011, Punjab, India

DOI:

https://doi.org/10.22159/ijcpr.2025v17i4.7010

Keywords:

Ficus religiosa, Anxiolytic, Antidepressant, Corticosterone levels, TST-Tail suspension test, EPM – elevated plus maze

Abstract

Objective: To evaluate Antidepressant and anxiolytic activity of Aqueous and Ethanolic extracts of Ficus religiosa adventitious in albino mice by using Forced swimming test (FST) and Tail suspension test (TST) parameters.

Methods: Healthy, adult swiss albino mice of either sex weighing (25-40 g), maintained under standard laboratory conditions, at temperature 25±2 °C and a 12 h light-12 h dark period will be employed for the experimentation. Food and water will be provided ad libitum. The behavioral effects of an acute or sub-acute (10 d course) will be orally administered. “Ficus religiosa” (250 and 500 mg/kg) aqueous and ethanolic extract of adventitious root will be evaluated in male and female Swiss mice by elevated plus-maze (EPM). The effects of diazepam (DZP; 1 mg/kg) will also assess. The Tail Suspension test (TST) will be used to assess the effects of an ethanolic and aqueous extract of Ficusreligiosa (250 and 500 mg/kg) on male and female Swiss mice. Additionally, the effects of fluoxetine (10 mg/kg) will be evaluated.

Results: In the present study, we have undertaken the antidepressant activity and anxiolytic activity of ethanolic and aqueous extracts Ficus religiosa adventitious in Swiss albino mice, at the dose of 250 and 500 mg/kg with oral administration respectively.

Conclusion: In conclusion both the extracts ethanolic and aqueous extracts of Ficus religiosa adventitious have shown significant results as an antidepressant effect and anxiolytic activity using forced swim test (FST) and Tail Suspension test (TST) parameters.

Downloads

Download data is not yet available.

References

1. Sekhon S, Gupta V. Mood disorder. In: Treasure Island, (FL): StatPearls Publishing; 2023 May 8. PMID 32644337.

2. https://my.clevelandclinic.org/Health/diseases/17843-Mood-Disorders.

3. Chand SP, Marwaha R. Anxiety. In: Treasure Island, (FL): StatPearls Publishing; 2023 Apr 24. PMID 29262212.

4. Munir S, Takov V. Generalized anxiety disorder. In: Treasure Island, (FL): StatPearls Publishing; 2022 Oct 17. PMID 28722900.

5. Department of Error. Lancet. 2021 Mar 6;397(10277):880. doi: 10.1016/S0140-6736(21)00473-6, PMID 33676627.

6. https://www.psychiatry.org/patients-families/anxiety-disorders/what-areanxiety-disorders.

7. Kaur R. A review article for herbal drugs as anxiolytic activity. Int J of Allied Med Sci and Clin Res. 2020 Aug 8;5(2):636-47.

8. Prasad PV, Subhaktha PK, Narayana A, Rao MM. Medico historical study of asvattha (sacred fig tree). Bull Indian Inst Hist Med (Hyderabad). 2006;36(1):1-20. PMID 18175640.

9. Gupta S, Porwal MC, Roy PS. Indigenous knowledge on some medicinal plants among the nicobari tribe of car nicobar Island. Indian J Tradit Know. 2004;3(3):287-93.

10. Nair R, Chanda SV. Antibacterial activities of some medicinal plants of the Western Region of India. Turk J Biol. 2007;31(4):231-6.

11. Choudhary GP. Evaluation of ethanolic extract of ficus religiosa bark on incision and excision wounds in rats. PlantaIndica. 2006;2(3):17-9.

12. Chandrasekar SB, Bhanumathy M, Pawar AT, Somasundaram T. Phytopharmacology of ficus religiosa. Pharmacogn Rev. 2010 Jul;4(8):195-9. doi: 10.4103/0973-7847.70918, PMID 22228961, PMCID PMC3249921.

13. Devanesan EB, Vijaya Anand AV, Kumar PS, Vinayagamoorthy P, Basavaraju P. Phytochemistry and pharmacology of ficus religiosa. Syst Rev Pharm. 2018 Jan 1;9(1):45-8. doi: 10.5530/srp.2018.1.9.