VARIOUS REASONS FOR CARDIOTOXICITY: AN UPDATED REVIEW
DOI:
https://doi.org/10.22159/ijcpr.2025v17i5.7022Keywords:
Cardiotoxicity, Anthracyclines, Drug-induced cardiotoxicity, Pharmacogenomics, Heart diseases, PreventionAbstract
Injury to the heart muscle caused by exposure to toxins is called cardiotoxicity and it weakens cardiac function. Cardiotoxicity is one of the most severe adverse effects of cancer treatment and significantly adds to morbidity and mortality. Ventricular systolic dysfunction-induced heart failure is the most frequent and lethal side effect of chemotherapy drugs on the cardiovascular system. Arrhythmias, myocardial ischemia, pericardial disease, hypertension, and thromboembolic disease are additional deleterious consequences. It is a critical problem in environmental health, cancer, and clinical pharmacology. Drug-induced cardiotoxicity (DICT) is a serious problem with drug safety in both clinical use and drug development. The primary reasons for cardiotoxicity are discussed in this research with a focus on drug-induced mechanisms, environmental exposures, genetic susceptibility, and clinical conditions posing threats to cardiac well-being.
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Copyright (c) 2025 KANAV KALRA, AJEET PAL SINGH, AMAR PAL SINGH
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