EVALUATION OF ANTIDEPRESSANT ACTIVITY OF AEGLEMARMELOS FRUIT EXTRACTS IN MICE

SAVITA; AJEET PAL SINGH; AMAR PAL SINGH

doi:10.22159/ijcpr.2025v17i5.7025

Authors

SAVITA Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R. E. C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar-144011, Punjab, India
AJEET PAL SINGH Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R. E. C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar-144011, Punjab, India
AMAR PAL SINGH Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R. E. C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar-144011, Punjab, India

DOI:

https://doi.org/10.22159/ijcpr.2025v17i5.7025

Keywords:

Aeglemarmelos, Antidepressant, FST – forced swim test, TST – Tail suspension test

Abstract

Objective: To evaluate Antidepressant Activity of Aqueous and Ethanolic extracts of Aeglemarmelos fruit in albino mice by using Forced swimming test (FST) and Tail suspension test (TST) parameters.

Methods: For the study, 25–40 g healthy adult Swiss albino mice of both sexes will be housed in a conventional laboratory environment with a temperature of 25±2 °C, and a 12 h light–12 h dark cycle. Food and water will be offered ad libitum. The two antidepressant Animal model are used for asses the activity. A) Forced swimming test: This model requires the mice to swim or float for five minutes while submerged 40 cm in 23±1 °C of water in a glass cylinder. b) Tail suspension test in mice: In this model the mice are suspended at the edge of shelf approximately 58 cm above the tabletop by adhesive tape that is placed approximately 1 cm from the tip of the tail, and the duration of immobility is recorded for a 5 min duration.

Results: In the present study, we have undertaken the antidepressant activity of ethanolic and aqueous extracts of Aeglemarmelos in Swiss albino mice, at the dose of 250 and 500 mg/kg, respectively, with oral administration respectively.

Conclusion: In conclusion both the extracts ethanolic and aqueous extracts of Aeglemarmelos have shown significant results as an antidepressant effect using forced swim test (FST) and Tail Suspension test (TST) parameters.

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References

1. Brigitta B. Pathophysiology of depression and mechanisms of treatment. Dialogues Clin Neurosci. 2002 Mar;4(1):7-20. doi: 10.31887/DCNS.2002.4.1/bbondy, PMID 22033824, PMCID PMC3181668.

2. Monika S, Thirumal M, Kumar PR. Phytochemical and biological review of Aegle marmelos Linn. Future Sci OA. 2023 Mar 1;9(3). doi: 10.2144/fsoa-2022-0068.

3. Singh R, Singh A, Babu N. Ethno-medicinal and Pharmacological activities of Aegle marmelos (Linn.) Corr: a review. J Pharm Innov J. 2019;8(6):176-81.

4. Lamia SS, Shimo MS, Rashed SS, Prima AA, Mony AT, Dash PR. Phytochemistry and pharmacological properties of Aegle marmelos l (Rutaceae): a review. Phytochemistry. 2018 May;3(3):45-54.

5. Choudhary Y, Saxena A, Kumar Y, Kumar S, Pratap V. Phytochemistry, pharmacological and traditional uses of Aegle marmelos. Pharmaceutical and Biosciences Journal. 2017 Oct 20:27-33.

6. Pandey MM, Rawat AK. Pharmacognosy and pharmacopoeial standards for Syzygium cumini. In: The genus Syzygium. CRC Press; 2017 Apr 7. p. 119-32.

7. Nain JY, Bhatt SH, Dhyani S, Joshi NU. Phytochemical screening of secondary metabolites of Datura stramonium. Int J Curr Pharm Res. 2013;5(2):151-3.

8. Gribaldo L, Gennari A, Blackburn K, Clemedson C, Deguercy A, Meneguz A. Acute toxicity. Altern Lab Anim. 2005 Jul;33(1Suppl 1):27-34. doi: 10.1177/026119290503301s07, PMID 16194139.

9. Vogel HG, editor. Drug discovery and evaluation: pharmacological assays. 2nd ed. Springer Science+Business Media; 2002 Jun 13. p. 17-72.

10. Taiwo AE, Leite FB, Lucena GM, Barros M, Silveira D, Silva MV. Anxiolytic and antidepressant-like effects of Melissa officinalis (lemon balm) extract in rats: influence of administration and gender. Indian J Pharmacol. 2012 Mar-Apr;44(2):189-92. doi: 10.4103/0253-7613.93846, PMID 22529473.

11. Kant GJ, Leu JR, Anderson SM, Mougey EH. Effects of chronic stress on plasma corticosterone, ACTH and prolactin. Physiol Behav. 1987 Jan 1;40(6):775-9. doi: 10.1016/0031-9384(87)90282-4, PMID 2823307.

12. Garrido P, de Blas M, Del Arco A, Segovia G, Mora F. Aging increases basal but not stress-induced levels of corticosterone in the brain of the awake rat. Neurobiol Aging. 2012 Feb 1;33(2):375-82. doi: 10.1016/j.neurobiolaging.2010.02.015, PMID 20416975.

13. Handa RJ, Burgess LH, Kerr JE, O’Keefe JA. Gonadal steroid hormone receptors and sex differences in the hypothalamo-pituitary-adrenal axis. Horm Behav. 1994 Dec 1;28(4):464-76. doi: 10.1006/hbeh.1994.1044, PMID 7729815.

14. Bhattacharya S, Herrera Molina R, Sabanov V, Ahmed T, Iscru E, Stober F. Genetically induced retrograde amnesia of associative memories after neuroplastin ablation. Biol Psychiatry. 2017 Jan 15;81(2):124-35. doi: 10.1016/j.biopsych.2016.03.2107, PMID 27215477.

15. Petrella C, Giuli C, Agostini S, Bacquie V, Zinni M, Theodorou V. Maternal exposure to low levels of corticosterone during lactation protects against experimental inflammatory colitis-induced damage in adult rat offspring. PLOS One. 2014 Nov 18;9(11):e113389. doi: 10.1371/journal.pone.0113389, PMID 25405993.

EVALUATION OF ANTIDEPRESSANT ACTIVITY OF AEGLEMARMELOS FRUIT EXTRACTS IN MICE

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