SUPERPOROUS HYDROGELS: CHARACTERISTICS AND APPLICATIONS IN THE DEVELOPMENT OF PHARMACEUTICAL FORMULATION
DOI:
https://doi.org/10.22159/ijcpr.2025v17i3.55045Keywords:
Superporous Hydrogels, Characteristics, Applications, Development of PharmaceuticalAbstract
Drug delivery advancements are playing a major role in the pharmaceutical industry for delivering new chemical entities that are not able to reach the commercial market owing to challenges in their absorption, metabolism or any other issue. Gastroretentive drug delivery systems are one such approach that is being developed for drugs with narrow therapeutic index and have absorption window in stomach. Hydrogels were developed basically as a means to regulate drug release when compared to conventional dosage forms [1].
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Deepthi B, Varun D, Gopal PN, Rao CH, Sumalatha G. Super porous hydrogels supreme drug delivery. Research Journal of Pharmacy and Technology. 2011;4(8):1182-8.
Thakur S, Thakur VK, Arotiba O. A history classification properties and application of hydrogels: an overview. In: Thakur V, Thakur M, editors. Hydrogels. Gels horizons: from science to smart materials. Singapore: Springer; 2018.
Bemmelen JM. Der hydrogel und das kristallinische hydrat des kupferoxydes. Z Anorg Chem. 1894;5:466.
Wichterle O, Lim D. Hydrophilic gels for biological use. Nature. 1960;185(4706):117-8. doi: 10.1038/185117a0.
Baldaniya LH, NA S. Hydrogels: a versatile drug delivery carrier systems. PCI- Approved-IJPSN. 1970;5(3):1745-56. doi: 10.37285/ijpsn.2012.5.3.1.
Ahmed JA, Chatterjee A, Chauhan BS, Jaimini M, Varshney HM. Conceptual overview on superporous hydrogels. Composites. 2014;25(2):166-73.
Dwivedi S, Khatri P, Mehra GR, Kumar V. Hydrogel a conceptual overview. Int J Pharm Biol Arch. 2011;2(6):1588-97.
Ganji F, Farahani SV, Farahani EV. Theoretical description of hydrogel swelling: a review. Iran Polym J. 2010;19(5):375-98.
Gemeinhart RA, Park H, Park K. Pore structure of superporous hydrogels. Polym Adv Technol. 2000;11(8-12):617-25. doi: 10.1002/1099-1581(200008/12)11:8/12<617::AID-PAT12>3.0.CO;2-L.
Superporous Omidian H, Park K. Hydrogels for drug delivery systems. Biomaterials. 2011:563-76.
Ullah F, Othman MB, Javed F, Ahmad Z, Akil HM. Mater Sci Eng C. 2015 Dec 1;1(57):414-33. doi: 10.1016/j.msec.2015.07.053.
Kuang J, Yuk KY, Huh KM. Polysaccharide based superporous hydrogels with fast swelling and superabsorbent properties. Carbohydr Polym. 2011;83(1):284-90. doi: 10.1016/j.carbpol.2010.07.052.
Kumari PV, Sharmila M, Rao YS. Super porous hydrogels: a review. JPRI. 2020;32(13):153-65. doi: 10.9734/jpri/2020/v32i1330595.
Bagadiya A, Kapadiya M, Mehta K. Superporous hydrogel: a promising tool for gastro retentive drug delivery system. Int J Pharm Technol. 2011;3(4):1556-71.
Prinderre P, Sauzet C, Fuxen C. Advances in gastro retentive drug delivery systems. Expert Opin Drug Deliv. 2011;8(9):1189-203. doi: 10.1517/17425247.2011.592828, PMID 21671821.
Patel PK, Mistry SN, Patel GJ, Bharadia PD, Pandya VM, Modi DA. Recent in controlled drug delivery system: superporous hydrogels. J Pharm Cosmetol. 2011;1(5):53-65.
Chen J, Park H, Park K. Synthesis of superporous hydrogels: hydrogels with fast swelling and superabsorbent properties. J Biomed Mater Res. 1999;44(1):53-62. doi: 10.1002/(sici)1097-4636(199901)44:1<53::aid-jbm6>3.0.co;2-w, PMID 10397904.
Chen J, Park K. Superporous hydrogels: fast responsive hydrogel systems. J Macromol Sci Pure Appl Chem. 1999;A36:917-30. doi: 10.1080/10601329908951189.
Chen J, Park K. Synthesis and characterization of superporous hydrogel composites. J Control Release. 2000;65(1-2):73-82. doi: 10.1016/s0168-3659(99)00238-2, PMID 10699272.
Park K, Chen J, Park H. Superporous hydrogel composites: a new generation of hydrogels with fast swelling kinetics high swelling ratio and high mechanical strength. In: Ottenbrite R, Kim SW, editors. Polymeric Drugs and Drug Delivery systems. Boca Raton: CRC Press; 2001. p. 145-56.
Park K, Chen J, Park H. Superporous hydrogel composites: a new generation of hydrogels with fast swelling kinetics high swelling ratio and high mechanical strength. In: Ottenbrite R, Kim SW, editors. Polymeric Drugs and Drug Delivery systems. Boca Raton, FL: CRC Press; 2001.
Mastropietro DJ, Omidian H, Park K. Drug delivery applications for superporous hydrogels. Expert Opin Drug Deliv. 2012 Jan 1;9(1):71-89. doi: 10.1517/17425247.2012.641950, PMID 22145909.
Omidian H, Park K, Rocca JG. Recent developments in superporous hydrogels. J Pharm Pharmacol. 2007 Mar;59(3):317-27. doi: 10.1211/jpp.59.3.0001, PMID 17331335.
Omidian H, Qiu Y, Yang S, Kim D, Park H, Park K. Hydrogels having enhanced elasticity and mechanical strength properties. US Patent 6960617; 2005.
Omidian H, Rocca JG, Park K. Elastic superporous hydrogel hybrids of polyacrylamide and sodium alginate. Macromol Biosci. 2006;6(9):703-10. doi: 10.1002/mabi.200600062, PMID 16967483.
Chen J, Park H, Park K. Synthesis of superporous hydrogels: hydrogels with fast swelling and superabsorbent properties. J Biomed Mater Res. 1999 Jan;44(1):53-62. doi: 10.1002/(sici)1097-4636(199901)44:1<53::aid-jbm6>3.0.co;2-w, PMID 10397904.
Nagpal M, Singh SK, Mishra D. Superporous hybrid hydrogels based on polyacrylamide and chitosan: characterization and in vitro drug release. Int J Pharm Investig. 2013;3(2):88-94. doi: 10.4103/2230-973X.114906, PMID 24015380.
Mayur C, Senthilkumaran K, Hemant G. Super porous hydrogels: a recent advancement in gastroretentive drug delivery system. Indonesian J Pharm. 2013;24(1):1-3.
Kumar KA, Reddy MS, Manohara P, Babu PS. A review on gastro retentive superporous hydrogels and its generations. J Chem Pharm Sci. 2012;5(2):78-81.
Patel NP, Pandya VM, Bharadia PD. Recent development in superporous hydrogel. Int J Univers Pharm Life Sci. 2012;2(3):147-59.
Rzaev ZM, Dincer S, Piskin E. Functional copolymers of N-isopropyl acrylamide for bioengineering applications. Prog Polym Sci. 2007;32(5):534-95.
Kim D, Seo K, Park K. Polymer composition and acidification effects on the swelling and mechanical properties of poly(acrylamide-co-acrylic acid) superporous hydrogels. J Biomater Sci Polym Ed. 2004;15(2):189-99. doi: 10.1163/156856204322793575, PMID 15109097.
Haxhinasto KB, English AE, Moy AB. Equilibrium and non-equilibrium charge dependent quantification of endothelial cell hydrogel scaffolds. J Mater Sci Mater Med. 2008;19(5):1999-2008. doi: 10.1007/s10856-007-3277-1, PMID 17952566.
Kabiri K, Omidian H, Hashemi SA, Zohuriaan Mehr MJ. Synthesis of fast swelling superabsorbent hydrogels: effect of crosslinker type and concentration on porosity and absorption rate. Eur Polym J. 2003;39(7):1341-8. doi: 10.1016/S0014-3057(02)00391-9.
Gemeinhart RA, Park H, Park K. Effect of compression on fast swelling of poly(acrylamide-co-acrylic acid) superporous hydrogels. J Biomed Mater Res. 2001;55(1):54-62. doi: 10.1002/1097-4636(200104)55:1<54::aid-jbm80>3.0.co;2-y, PMID 11426398.
Rocca JG, Omidian H, Shah K. Controlled release of compounds mediated by retention in the upper part of the GI tract. In: The 30th Annual Meeting and Exposition of the Controlled Release Society (CRS) Glasgow Scotland; 2003.
Rocca JG, Omidian H, Shah K. Business briefing. Pharm Technol. 2003:152-6.
Rocca JG, Omidian H, Shah K. Drug Deliv Technol. 2005;5:40-6.
Rocca JG, Shah K, Omidian H. Superporous hydrogels containing solid and semi-solid carriers. Gattefosse Tech Bull. 2004;97:73-84.
Dorkoosh FA, Borchard G, Rafiee Tehrani M, Verhoef JC, Junginger HE. Evaluation of superporous hydrogel (SPH) and SPH composite in porcine intestine ex-vivo: assessment of drug transport morphology effect and mechanical fixation to intestinal wall. Eur J Pharm Biopharm. 2002;53(2):161-6. doi: 10.1016/s0939-6411(01)00222-3, PMID 11879998.
Dorkoosh FA, Verhoef JC, Borchard G, Rafiee Tehrani M, Junginger HE. Development and characterization of a novel peroral peptide drug delivery system. J Control Release. 2001;71(3):307-18. doi: 10.1016/s0168-3659(01)00232-2, PMID 11295223.
Dorkoosh FA, Verhoef JC, Verheijden JH, Rafiee Tehrani M, Borchard G, Junginger HE. Peroral absorption of octreotide in pigs formulated in delivery systems on the basis of superporous hydrogel polymers. Pharm Res. 2002;19(10):1532-6. doi: 10.1023/a:1020416918624, PMID 12425472.
Han W, Omidian H, Rocca JG. A novel acrylate ester based superporous hydrogel. In: The 32nd Annual Meeting of the Controlled Release Society (CRS), Miami; 2005.
Dorkoosh FA, Verhoef JC, Borchard G, Rafiee Tehrani M, Junginger HE. Development and characterization of a novel peroral peptide drug delivery system. J Control Release. 2001;71(3):307-18. doi: 10.1016/s0168-3659(01)00232-2, PMID 11295223.
Dorkoosh FA, Coos Verhoef JC, Ambagts MH, Rafiee Tehrani M, Borchard G, Junginger HE. Peroral delivery systems based on superporous hydrogel polymers: release characteristics for the peptide drugs buserelin octreotide and insulin. Eur J Pharm Sci. 2002;15(5):433-9. doi: 10.1016/s0928-0987(02)00028-3, PMID 12036720.
Polnok A, Verhoef JC, Borchard G, Sarisuta N, Junginger HE. In vitro evaluation of intestinal absorption of desmopressin using drug delivery systems based on superporous hydrogels. Int J Pharm. 2004;269(2):303-10. doi: 10.1016/j.ijpharm.2003.09.022, PMID 14706242.
Dorkoosh FA, Borchard G, Rafie Tehrani M VJH, VerhoefJunginger HE. Intestinal absorption of insulin in pigs using delivery systems based on superporous hydrogels polymers. International Journal of Pharmaceutics. 2002 Oct 24;247(1-2):47-55.
Yang S, FU Y, Jeong SH, Park K. Application of poly(acrylic acid) superporous hydrogel microparticles as a super disintegrant in fast disintegrating tablets. J Pharm Pharmacol. 2004;56(4):429-36. doi: 10.1211/0022357023015.
Askari F, Nafisi S, Omidian H. Synthesis and characterization of acrylic based super absorbents. J Appl Polym Sci. 1993;50(10):1851-5.
Pradny M, Slouf M, Martinova L. Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 7: Methods of preparation and comparison of resulting physical properties. E-Polymers. 2010;43:1-12.
Cetin D, Kahraman AS, Gumusderelioglu M. Novel scaffolds based on poly(2-hydroxyethyl methacrylate) superporous hydrogels for bone tissue engineering. J Biomater Sci Polym Ed. 2011;22(9):1157-78. doi: 10.1163/092050610X501704, PMID 20615330.
Jayakrishnan A, Mohanty M, Mandalam R, Rao VR, Gupta AK, Joseph S. Endovascular embolization using hydrogel microspheres. J Mater Sci Mater Med. 1994;5(9-10):723-7. doi: 10.1007/BF00120364.
Liu C, Wei N, Wang S, XU Y. Preparation and characterization superporous hydroxypropyl methylcellulose gel beads. Carbohydr Polym. 2009;78(1):1-4. doi: 10.1016/j.carbpol.2009.02.024.
Chen J, Park K. Synthesis and characterization of superporous hydrogel composites. J Control Release. 2000;65(1-2):73-82. doi: 10.1016/s0168-3659(99)00238-2, PMID 10699272.
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