COMPARISON BETWEEN ISOFLURANE AND SEVOFLURANE IN THE MAINTENANCE OF HYPOTENSIVE ANAESTHESIA IN ENDOSCOPIC SINUS SURGERIES

KOTHAPALLI TEJA SRI RAKESH; NANNA VARUN KOUSHIK; RATHNAPURAM LAXMAN

doi:10.22159/ijcpr.2025v17i6.7066

Authors

KOTHAPALLI TEJA SRI RAKESH Department of Anaesthesiology, Government Medical College and General Hospital, Sangareddy, Telangana, India
NANNA VARUN KOUSHIK Department of Emergency Medicine, Government Medical College and General Hospital, Mahabubabad, Telangana, India
RATHNAPURAM LAXMAN Department of Anaesthesiology, Government Medical College and General Hospital, Sangareddy, Telangana, India.

DOI:

https://doi.org/10.22159/ijcpr.2025v17i6.7066

Keywords:

Sevoflurane, Isoflurane, Endoscopic sinus surgery, Hypotensive anaesthesia

Abstract

Objective: To compare the efficacy of isoflurane and sevoflurane in maintaining controlled hypotensive anesthesia during ESS, focusing on intraoperative hemodynamics, blood loss, surgical field quality, recovery profile, and postoperative pain.

Methods: This prospective randomized study included 80 ASA I/II patients aged 18–60 undergoing elective ESS. Patients were divided into two groups: Group I received isoflurane and Group S received sevoflurane. Hemodynamic parameters (MAP, HR), blood loss, surgical field visibility, recovery times, and postoperative pain (VAS scores) were recorded and analyzed statistically.

Results: Sevoflurane significantly maintained lower MAP and HR during surgery (p<0.05) and was associated with reduced intraoperative blood loss (110.6±18.9 ml vs. 135.2±20.3 ml; p = 0.001) and improved surgical field scores (p = 0.002). Recovery was faster in Group S across all parameters, including eye opening, extubation, and orientation (p<0.001). Postoperative pain scores were consistently lower in the sevoflurane group during the early recovery period (p<0.05).

Conclusion: Sevoflurane proved superior to isoflurane in achieving controlled hypotension, reducing blood loss, improving the surgical field, enhancing recovery profile, and minimizing early postoperative pain in patients undergoing ESS. It is therefore a preferred agent for maintaining hypotensive anesthesia in such procedures.

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