EFFICACY OF ULTRASOUND-GUIDED SAPHENOUS NERVE BLOCK USING BUPIVACAINE ALONE VERSUS BUPIVACAINE WITH TRIAMCINOLONE ACETONIDE IN OSTEOARTHRITIS KNEE PAIN
DOI:
https://doi.org/10.22159/ijcpr.2025v17i6.7074Keywords:
Knee osteoarthritis, Saphenous nerve block, Ultrasound-guided block, Bupivacaine, triamcinolone acetonide, Chronic knee painAbstract
Objective: Knee osteoarthritis (OA) is a prevalent cause of chronic pain and functional impairment. Ultrasound-guided saphenous nerve block has emerged as a promising non-surgical treatment modality. This study evaluates the comparative efficacy of bupivacaine alone versus bupivacaine with triamcinolone acetonide in ultrasound-guided saphenous nerve block for OA knee pain.
Methods: A prospective, randomized, double-blind study was conducted involving 80 patients aged 30–80 y with chronic OA knee pain (Grade II or III). Patients were allocated to two groups: Group T received 4 ml of 0.5% bupivacaine+40 mg triamcinolone acetonide; Group B received 4 ml of 0.5% bupivacaine alone. Both solutions were diluted to 10 ml with normal saline. Pain intensity (VAS), functional disability (WOMAC index), and patient satisfaction were assessed at baseline, 1 h, 1 w, 2 w, 1 mo, 3 mo, and 6 mo post-block.
Results: Both groups showed significant reductions in VAS and WOMAC scores over time (p<0.05). However, Group T showed superior pain relief and functional improvement at all follow-up points (p<0.05). Grade II OA patients in both groups had better outcomes compared to Grade III. No significant procedural complications were noted.
Conclusion: Ultrasound-guided saphenous nerve block using bupivacaine with triamcinolone acetonide provides prolonged and superior analgesia and functional improvement compared to bupivacaine alone in patients with OA knee. This technique is safe, effective, and minimally invasive, warranting consideration in non-surgical OA knee management.
Downloads
References
1. Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum. 1998;41(8):1343-55. doi: 10.1002/1529-0131(199808)41:8<1343::AID-ART3>3.0.CO;2-9, PMID 9704632.
2. WHO Scientific Group. The burden of musculoskeletal conditions at the start of the new millennium. World Health Organ Tech Rep Ser. 2003;919:1-128.
3. Neogi T. The epidemiology and impact of pain in osteoarthritis. Osteoarthr Cartil. 2013;21(9):1145-53. doi: 10.1016/j.joca.2013.03.018, PMID 23973124.
4. AAOS. Treatment of osteoarthritis of the knee. In: Evidence-based guideline. 2nd ed. Rosemont: Am Acad Orth Surg; 2013. doi: 10.5435/JAAOS-21-09-571.
5. Hart DJ, Doyle DV, Spector TD. Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study. Arthritis Rheum. 1999;42(1):17-24. doi: 10.1002/1529-0131(199901)42:1<17::AID-ANR2>3.0.CO;2-E, PMID 9920009.
6. Goldring SR, Goldring MB. Clinical aspects pathology and pathophysiology of osteoarthritis. J Musculoskelet Neuronal Interact. 2006;6(4):376-8. PMID 17185832.
7. Watson M. Management of patients with osteoarthritis. Pharm J. 1997;259:296-7.
8. Michael JW, Schluter Brust KU, Eysel P. The epidemiology etiology diagnosis and treatment of osteoarthritis of the knee. Dtsch Arztebl Int. 2010;107(9):152-62. doi: 10.3238/arztebl.2010.0152, PMID 20305774.
9. Goldring SR, Goldring MB. Clinical aspects pathology and pathophysiology of osteoarthritis. J Musculoskelet Neuronal Interact. 2006;6(4):376-8. PMID 17185832.
10. Dieppe PA, Sathapatayavongs B, Jones HE, Bacon PA, Ring EF. Intra-articular steroids in osteoarthritis. Rheumatol Rehabil. 1980;19(4):212-7. doi: 10.1093/rheumatology/19.4.212, PMID 7010511.
11. Horner G, Dellon AL. Innervation of the human knee joint and implications for surgery. Clin Orthop Relat Res. 1994;(301):221-6. doi: 10.1097/00003086-199404000-00034, PMID 8156678.
12. Partownavid P. Ultrasound-guided peripheral nerve block. Am J Ther. 2009;16(4):304-12. doi: 10.1097/MJT.0b013e3181715684, PMID 19531938.
13. Manickam B, Perlas A, Duggan E, Brull R, Chan VW, Ramlogan R. Feasibility and efficacy of ultrasound-guided block of the saphenous nerve in the adductor canal. Reg Anesth Pain Med. 2009;34(6):578-80. doi: 10.1097/aap.0b013e3181bfbf84, PMID 19916251.
14. Eckmann MS. Saphenous nerve block shows promise for chronic knee pain. Int Anesth Res Soc. 2009 Aug 7(8):11.
15. Harshe R. Prolonged knee pain relief by saphenous block (new technique). Indian J Pain. 2013;27(1):36-40. doi: 10.4103/0970-5333.114871.
16. Loteroa MA, Diazb RR, Mejia Aguilarc MA, Jaramillo SJ. Efficacy and safety of ultrasound-guided saphenous nerve block in patients with chronic knee pain. Colomb J Anestn. 2014;42(3):166-71. doi: 10.1016/j.rca.2014.03.005.
17. Tsai PB, Karnwal A, Kakazu C, Tokhner V, Julka IS. Efficacy of an ultrasound-guided subsartorial approach to saphenous nerve block: a case series. Can J Anaesth. 2010;57(7):683-8. doi: 10.1007/s12630-010-9317-1, PMID 20428987.
18. Lin Y, Liu SS. Local anesthetics. In: Barash PG, Cullen B, Stoelting RK, Chahalan MK, Stock MC, Rafeal O, editors. Clinical Anesthesia. 7th ed. Philadelphia: Lippincott; 2013. p. 562-8.
19. Mackinnon SE, Hudson AR, Gentili F, Kline DG, Hunter D. Peripheral nerve injection injury with steroid agents. Plast Reconstr Surg. 1982;69(3):482-90. doi: 10.1097/00006534-198203000-00014, PMID 7063571.
20. Stan T, Goodman EJ, Bravo Fernandez C, Holbrook CR. Adding methylprednisolone to local anesthetic increases the duration of axillary block. Reg Anesth Pain Med. 2004;29(4):380-1. doi: 10.1016/j.rapm.2004.03.006, PMID 15305267.
21. Devor MD, Govrin Lippmann R, Raber P. Corticosteroids suppress ectopic neural discharge originating in experimental neuromas. Pain. 1985;22(2):127-37. doi: 10.1016/0304-3959(85)90173-3, PMID 4047699.
22. Hooten WM. Assessment and management of chronic pain. Institute for Clinical Systems Improvement. 2013;6:1-105.
23. Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol. 1988;15(12):1833-40. PMID 3068365.
Published
How to Cite
Issue
Section
Copyright (c) 2025 ARJUN PIRKAD, SUHEELA TAXAK, DRPOONAM SINGH

This work is licensed under a Creative Commons Attribution 4.0 International License.