EVALUATION OF SERUM PROLACTIN LEVEL IN CIRRHOSIS OF LIVER AND ITS CORRELATION WITH CHILD-TURCOTTE-PUGH SCORE

ADITYA GOYAL; PANKAJ BANSAL; ABHISHEK DEEPAK

doi:10.22159/ijcpr.2025v17i6.7076

Authors

ADITYA GOYAL Department of General Medicine, SMSR, Sharda University, Greater Noida, Uttar Pradesh, India https://orcid.org/0009-0004-8475-3161
PANKAJ BANSAL Department of General Medicine, SMSR, Sharda University, Greater Noida, Uttar Pradesh, India
ABHISHEK DEEPAK Department of General Medicine, SMSR, Sharda University Greater Noida, Uttar Pradesh, India

DOI:

https://doi.org/10.22159/ijcpr.2025v17i6.7076

Keywords:

Serum, Cirrhosis of liver, Its correlation

Abstract

Objective: The objective of this study was to determine serum prolactin levels in patients with liver cirrhosis and evaluate its correlation with the Child-Turcotte-Pugh (CTP) score.

Methods: This observational cross-sectional study was conducted at the Department of General Medicine, School of Medical Sciences and Research, Sharda University, Greater Noida. A total of 50 cirrhotic patients fulfilling the inclusion criteria were enrolled. Each participant provided informed consent, followed by a detailed clinical assessment and biochemical tests.

Results: The majority of patients fell within the 41–50 age group. Alcohol was identified as the most prevalent cause of cirrhosis, followed by Hepatitis B virus (HBV), Hepatitis C virus (HCV), and Non-Alcoholic Steatohepatitis (NASH). The mean prolactin levels observed for Child-Pugh grades A, B, and C were 25±2.83, 44.30±9.52, and 76.35±33.84 respectively. A statistically significant correlation (p<0.05) was found between prolactin levels and the Child-Pugh score (r=0.42, p=0.002), indicating that higher disease severity corresponded with elevated prolactin levels.

Conclusion: Serum prolactin levels demonstrated a strong association with the Child-Pugh score, signifying their potential as an early marker for liver cirrhosis seveCirrhosis of liverrity and prognosis.

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