BIOCHEMICAL ALTERATIONS IN MUSCLE AND RENAL MARKERS IN THYROID DISEASE: A CROSS-SECTIONAL STUDY

RAASHIKA SAXENA; ARVIND KUMAR GUPTA

doi:10.22159/ijcpr.2025v17i6.7082

Authors

RAASHIKA SAXENA Department of Biochemistry, Dr. Ulhas Patil Medical College and Hospital, Jalgaon, Maharashtra, India
ARVIND KUMAR GUPTA Department of Biochemistry, RD Gardi Medical College, Ujjain, M. P., India https://orcid.org/0009-0002-2818-4553

DOI:

https://doi.org/10.22159/ijcpr.2025v17i6.7082

Keywords:

Thyroid dysfunction, Creatine kinase, Lactate dehydrogenase, Hypothyroidism, and Serum creatinine

Abstract

Objective: The study aimed to assess and compare serum levels of CK, LDH, and creatinine in patients with hypothyroidism and hyperthyroidism with those in euthyroid (healthy) controls, to elucidate the metabolic alterations and their clinical relevance.

Methods: This was a hospital-based cross-sectional study conducted on 90 participants, divided into three groups: Group I: 30 patients with hypothyroidism, Group II: 30 patients with hyperthyroidism, and Group III: 30 age-and sex-matched healthy controls. Fasting venous blood samples were analyzed for CK, LDH, and serum creatinine using standard enzymatic colorimetric methods.

Results: CK and LDH levels were significantly elevated in hypothyroid patients compared to controls (p<0.001), reflecting subclinical myopathy. In contrast, hyperthyroid patients showed moderately elevated LDH but not CK. Serum creatinine levels were higher in hypothyroidism and lower in hyperthyroidism compared to controls, suggesting thyroid state-dependent renal function modulation. Pearson correlation showed a negative correlation between TSH and eGFR, and a positive correlation between TSH and CK levels in hypothyroid subjects.

Conclusion: Thyroid dysfunction significantly alters muscle and renal biomarkers. Routine assessment of CK, LDH, and serum creatinine can aid in early detection of subclinical myopathy and renal involvement in thyroid patients. This may provide insights for better metabolic monitoring and management of thyroid disorders.

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References

1. Nayak B, Burman K. Thyrotoxicosis and hyperthyroidism. Med Clin North Am. 2012;96(2):245-60.

2. Cooper DS. Clinical practice. Subclinical hypothyroidism. N Engl J Med. 2001;345(4):260-5. doi: 10.1056/NEJM200107263450406, PMID 11474665.

3. Kamath C, Raghupathi K, Bhat R. A study of creatine kinase lactate dehydrogenase activity and serum creatinine in thyroid dysfunction. Int J Health Sci Res. 2020;10(2):79-84.

4. Peixoto De Miranda EJ, Rodrigues FF, Pereira RM. Muscle enzymes in hypothyroidism: an overview. Arq Bras Endocrinol Metab. 2010;54(5):405-12.

5. Palaniappan M, Sundararajan P, Panneerselvam S. Study of serum CK and LDH levels in hypothyroid patients. Int J Adv Med. 2017;4(3):648-52.

6. Tseng FY, Lin WY, Lin CC, Lee LT, Li TC, Sung PK. Subclinical hypothyroidism is associated with increased risk for all cause and cardiovascular mortality in adults. J Am Coll Cardiol. 2012;60(8):730-7. doi: 10.1016/j.jacc.2012.03.047, PMID 22726629.

7. Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American association of clinical endocrinologists and the American thyroid association. Thyroid. 2012;22(12):1200-35. doi: 10.1089/thy.2012.0205, PMID 22954017.

8. Adachi JD. Corticosteroid induced osteoporosis. Am J Med Sci. 1997;313(1):41-9. doi: 10.1097/00000441-199701000-00007, PMID 9001165.

9. Kaminsky NI, Gimlette T. Creatine kinase in hypothyroid myopathy. Br Med J. 1977;1(6066):1015.

10. Arlot S, Debussche X, Lalau JD. Effects of thyroid dysfunction on renal function. J Endocrinol Invest. 1991;14(8):607-9.

11. Chaudhary N, Singh S, Garg MK. Serum creatine kinase and lactate dehydrogenase in patients with hypothyroidism and hyperthyroidism. Indian J Endocrinol Metab. 2013;17(6):1023-4.

12. Khaleeli AA, Edwards RH, Gohil K, Round JM. Muscle dysfunction in hypothyroidism. Clin Endocrinol (Oxf). 1983;19(6):686-96.

13. Mukhopadhyay P, Das AK, Roy D. Biochemical and clinical profile in hypothyroid patients. Indian J Clin Biochem. 2005;20(2):165-8.

14. Khandelwal D, Tandon N. Overt and subclinical hypothyroidism: who to treat and how. Drugs. 2012;72(1):17-33. doi: 10.2165/11598070-000000000-00000, PMID 22191793.

15. Rodondi N, Den Elzen WP, Bauer DC, Cappola AR, Razvi S, Walsh JP. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA. 2010;304(12):1365-74. doi: 10.1001/jama.2010.1361, PMID 20858880.

16. Costa Guda J, Lauter K, Naveh Many T, Silver J, Arnold A. Mutational analysis of the PTH 3′-untranslated region in parathyroid disorders. Clin Endocrinol (Oxf). 2006;65(6):806-9. doi: 10.1111/j.1365-2265.2006.02670.x, PMID 17121534.

17. Kaptein EM. Thyroid hormone metabolism and thyroid diseases in chronic renal failure. Endocr Rev. 1996;17(1):45-63. doi: 10.1210/edrv-17-1-45, PMID 8641223.

18. Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev. 2008;29(1):76-131. doi: 10.1210/er.2006-0043, PMID 17991805.

19. Lo JC, Chertow GM, Go AS, Hsu CY. Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney disease. Kidney Int. 2005;67(3):1047-52. doi: 10.1111/j.1523-1755.2005.00169.x, PMID 15698444.

20. Marwah S, Marwah N, Saikia UK. Assessment of renal function in hypothyroid patients. Int J Med Sci Public Health. 2013;2(3):589-92.

21. Hegedus L. Clinical practice the thyroid nodule. N Engl J Med. 2004;351(17):1764-71. doi: 10.1056/NEJMcp031436, PMID 15496625.