PROPOLIS AND ITS ADVANCED FORMULATIONS: CURRENT PERSPECTIVES IN DENTAL APPLICATIONS
DOI:
https://doi.org/10.22159/ijcpr.2025v17i6.8031Keywords:
Propolis, Dental applications, Advanced formulations, Dental caries, Drug delivery systemAbstract
Objective: To provide a detailed summary of advanced formulations of propolis for dental applications, focusing on strategies designed to enhance its therapeutic efficacy, solubility, stability, and overall clinical utility.
Methods: A comprehensive literature search was conducted using PubMed, Scopus, Web of Science, and Embase databases. Studies were included if they investigated propolis-based formulations relevant to dentistry, particularly those involving nanoparticles, nanoemulsions, mouth rinses, liposomes, or propolis incorporated into composites and sealants.
Results: Findings from the reviewed literature indicate that advanced delivery systems significantly improve the solubility, bioavailability, and biofilm penetration of propolis while prolonging its antimicrobial activity. Nanoparticles and nanoemulsions enhance propolis’s stability and therapeutic efficacy, whereas formulations such as mouth rinses, liposomes, and dental composites contribute to improved patient compliance, ease of administration, and usability. Collectively, these approaches support the role of propolis in dental caries prevention and overall oral health maintenance.
Conclusion: Advanced formulations of propolis successfully overcome limitations related to its natural form by enhancing stability, therapeutic performance, and patient-friendly delivery. Continued research should focus on clinical validation and the development of standardized propolis formulations for consistent and effective use in dental practice.
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