THYMOSINE, A T CELL MODULATOR IN COVID-19
DOI:
https://doi.org/10.22159/ijcpr.2026v18i1.8039Keywords:
COVID-19, Thymosine, T Cell, Lymphopenia, T cell polymorphismAbstract
The pandemic of Coronavirus Disease (COVID-19) has resulted in millions of deaths worldwide, and many big cities worldwide were under lockdown to contain the infection. Though the effectiveness of vaccines varies, people were getting infected with the Virus; however, the severity of clinical manifestations was variable. Many drugs used in the treatment of COVID-19 were being redirected from their original use and were used in COVID-19. Thymosineis involved in amplifying T cell maturation and enhances the specificity. Thymosineuse could potentiate the T cell response and naturally resist infections, and could help to contain infections.
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1. Le Page M. First known covid case was Wuhan market trader after all. New Sci. 2021 Nov 27;252(3362):18. doi: 10.1016/S0262-4079(21)02107-2, PMID 34866733.
2. Ticinesi A, Tuttolomondo D, Nouvenne A, Parise A, Cerundolo N, Prati B. Co-administration of remdesivir and azithromycin may protect against intensive care unit admission in COVID-19 pneumonia requiring hospitalization: a real-life observational study. Antibiotics (Basel). 2022;11(7):941. doi: 10.3390/antibiotics11070941, PMID 35884195.
3. Singh AK, Singh A, Singh R, Misra A. Remdesivir in COVID-19: a critical review of pharmacology, pre-clinical and clinical studies. Diabetes Metab Syndr. 2020;14(4):641-8. doi: 10.1016/j.dsx.2020.05.018, PMID 32428865.
4. Silva MJ, Rodrigues YC, Lima KV, Lima LN. Innate immunity to SARS-CoV-2 infection: a review. Epidemiol Infect. 2022;150:e142. doi: 10.1017/S095026882200125X, PMID 35843719.
5. Kalfaoglu B, Almeida Santos J, Tye CA, Satou Y, Ono M. T-cell dysregulation in COVID-19. Biochem Biophys Res Commun. 2021;538:204-10. doi: 10.1016/j.bbrc.2020.10.079, PMID 33220925.
6. Thachil J, Khorana A, Carrier M. Similarities and perspectives on the two C's-cancer and COVID-19. J Thromb Haemost. 2021;19(5):1161-7. doi: 10.1111/jth.15294, PMID 33725410.
7. Teixeira Ferreira R, Cardoso Ferreira I, Carmona S, Montalvao A, Santos AI. Spontaneous remission of high-grade non-Hodgkin lymphoma after SARS-CoV-2 infection: a case report. Clin Nucl Med. 2024;49(2):e77-9. doi: 10.1097/RLU.0000000000004973, PMID 38048523.
8. Potts DA, Fromm JR, Gopal AK, Cassaday RD. Spontaneous remission of an untreated MYC and BCL2 coexpressing high-grade B-cell lymphoma: a case report and literature review. Case Rep Hematol. 2017;2017:2676254. doi: 10.1155/2017/2676254, PMID 28321348.
9. Dominari A, Hathaway D, Pandav K, Matos W, Biswas S, Reddy G, Thevuthasan S, Khan MA, Mathew A, Makkar SS, Zaidi M, Fahem MMM, Beas R, Castaneda V, Paul T, Halpern J, Baralt D. Thymosin alpha 1: a comprehensive review of the literature. World J Virol. 2020;9(5):67-78. doi: 10.5501/wjv.v9.i5.67.
10. Janeway CA JR, Travers P, Walport M, Shlomchik MJ. Immunobiology: the immune system in health and disease. 5th ed. New York: Garland Science; 2001. Chapter: Generation of lymphocytes in bone marrow and thymus. Available from: https://www.ncbi.nlm.nih.gov/books/NBK27123.
11. Zhao Q, Meng M, Kumar R, Wu Y, Huang J, Deng Y. Lymphopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a systemic review and meta-analysis. Int J Infect Dis. 2020 Jul;96:131-5. doi: 10.1016/j.ijid.2020.04.086, PMID 32376308.
12. Sookaromdee P, Wiwanitkit V. Polymorphisms and severity of COVID-19. Am J Respir Crit Care Med. 2023;207(1):112. doi: 10.1164/rccm.202208-1494LE, PMID 36041212.
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