ANTIMICROBIAL RESISTANCE PATTERNS OF UROPATHOGENS CAUSING URINARY TRACT INFECTIONS AMONG THE ADULTS IN A TERTIARY CARE CENTRE-A DESCRIPTIVE STUDY
DOI:
https://doi.org/10.22159/ijcpr.2026v18i1.8009Keywords:
Urinary tract infection, Uropathogens, Antimicrobial resistance, Multi-drug resistance, Antibiotic stewardship, Kirby–bauer methodAbstract
Objective: Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, particularly affecting women. Rising antimicrobial resistance has made management increasingly challenging, especially in resource-limited settings. This study aimed to identify the predominant uropathogens causing UTIs in adults and evaluate their antimicrobial resistance patterns in a tertiary care hospital in Tirupati, Andhra Pradesh.
Methods: A descriptive study was conducted over three months (January–March 2025) in the Department of Microbiology. A total of 180 clean-catch midstream urine samples were collected from adults aged >18 years. Samples were cultured and isolates were identified by microbiological techniques. Antimicrobial susceptibility testing was performed using Kirby–Bauer disc diffusion method according to Clinical and Laboratory Standards Institute (CLSI) guidelines.
Results: Of the 180 patients, 71% were female, showing higher prevalence of UTIs in women. Infections were most frequent among individuals>60 years, followed by those in their 30s. Most samples were from the General Medicine department. Escherichia coli was the most common isolate, followed by Klebsiella pneumoniae. Both exhibited high resistance to amoxyclav and ciprofloxacin but were more susceptible to imipenem and nitrofurantoin. Pseudomonas aeruginosa and Proteus mirabilis also showed notable resistance. Among g-positive organisms, Enterococcus faecalis largely sensitive to linezolid and vancomycin.
Conclusion: The study highlights significant antimicrobial resistance among UTI pathogens. Routine surveillance and rational antibiotic prescribing based on local susceptibility data are essential to prevent resistance and improve outcomes.
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