QUALITY OF SLEEP AND ITS RELATIONSHIP WITH DEPRESSIVE SYMPTOMATOLOGY AND SUICIDALITY IN BIPOLAR DEPRESSION

Authors

  • BHASKAR ROY Department of Psychiatry, Burdwan Medical College and Hospital, Bardhaman, West Bengal, India
  • PRANAB DAS Department of Pharamacology, Pragjyotishpur Medical College and Hospital, Guwahati, Assam, India https://orcid.org/0009-0009-0229-3277

DOI:

https://doi.org/10.22159/ijcpr.2026v18i1.8051

Keywords:

Bipolar depression, Sleep quality, Suicidality, PSQI, Hamilton depression rating scale

Abstract

Objective: To evaluate the relationship between sleep quality, depressive symptomatology, and suicidality among patients with bipolar depression.

Methods: This hospital-based, cross-sectional observational study was conducted in the Department of Psychiatry, Burdwan Medical College and Hospital, West Bengal. Fifty participants fulfilling ICD-11 diagnostic criteria for bipolar affective disorder in the depressive phase were enrolled using simple random sampling. Standardized instruments were applied like Sleep Quality Scale (SQS) to assess subjective sleep parameters, Beck Depression Inventory (BDI) to quantify depressive severity, and Columbia–Suicide Severity Rating Scale (C-SSRS) to evaluate suicidality. Statistical analysis was performed using SPSS version 20.0, employing Pearson’s and Spearman’s correlation coefficients, with significance set at p<0.05.

Results: Participants demonstrated moderate sleep impairment (mean SQS score = 4.9±1.2) and significant depressive symptoms. A strong positive correlation was observed between SQS and BDI scores (r = 0.846, p<0.001), indicating that poorer sleep quality was associated with greater depressive severity. Sleep quality also correlated moderately with suicidal ideation (r = 0.49, p = 0.01) and suicidal behavior (r = 0.54, p = 0.01), underscoring the independent contribution of sleep disturbance to suicidality.

Conclusion: Sleep dysfunction constitutes a pivotal element in the psychopathology of bipolar depression, strongly influencing both mood intensity and suicidal risk. Integrating systematic sleep evaluation and targeted interventions such as circadian rhythm regulation and behavioral sleep therapy into routine management may enhance clinical outcomes and mitigate suicidal vulnerability in bipolar depressive patients.

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References

1. World Health Organization. Mental health: strengthening our response. Geneva: World Health Organization; 2019. Available from: https://www.who.int/news-room/fact-sheets/detail/mental-health-strengthening-our-response. [Last accessed on 31 Dec 2025].

2. World Health Organization. ICD-11 clinical descriptions and diagnostic guidelines for mental and behavioural disorders. Geneva: World Health Organization; 2022. Available from: https://www.who.int/publications/i/item/9789240077263. [Last accessed on 21 Oct 2025].

3. Riemann D, Berger M, Voderholzer U. Sleep and depression results from psychobiological studies: an overview. Biol Psychol. 2001 Jul-Aug;57(1-3):67-103. doi: 10.1016/S0301-0511(01)00090-4, PMID 11454435.

4. Armitage R. Sleep and circadian rhythms in mood disorders. Acta Psychiatr Scand Suppl. 2007;(433):104-15. doi: 10.1111/j.1600-0447.2007.00968.x, PMID 17280576.

5. Tsuno N, Besset A, Ritchie K. Sleep and depression. J Clin Psychiatry. 2005 Oct;66(10):1254-69. doi: 10.4088/JCP.v66n1008, PMID 16259539.

6. Kaplan KA, Harvey AG. Hypersomnia across mood disorders: a review and synthesis. Sleep Med Rev. 2009 Aug;13(4):275-85. doi: 10.1016/j.smrv.2008.09.001, PMID 19269201.

7. Harvey AG. Sleep and circadian rhythms in bipolar disorder: seeking synchrony harmony and regulation. Am J Psychiatry. 2008 Jul;165(7):820-9. doi: 10.1176/appi.ajp.2008.08010098, PMID 18519522.

8. Wehr TA, Sack DA, Rosenthal NE. Sleep reduction as a final common pathway in the genesis of mania. Am J Psychiatry. 1987 Feb;144(2):201-4. doi: 10.1176/ajp.144.2.201, PMID 3812788.

9. Plante DT, Winkelman JW. Sleep disturbance in bipolar disorder: therapeutic implications. Am J Psychiatry. 2008 Jul;165(7):830-43. doi: 10.1176/appi.ajp.2008.08010077, PMID 18483132.

10. Garcia Velazquez R, Jokela M, Rosenstrom TH. The varying burden of depressive symptoms across adulthood: results from six NHANES cohorts. J Affect Disord. 2019 Mar 1;246:290-9. doi: 10.1016/j.jad.2018.12.059, PMID 30594042.

11. Salk RH, Hyde JS, Abramson LY. Gender differences in depression in representative national samples: meta-analyses of diagnoses and symptoms. Psychol Bull. 2017 Aug;143(8):783-822. doi: 10.1037/bul0000102, PMID 28447828.

12. Blazer DG. Depression in late life: review and commentary. J Gerontol A Biol Sci Med Sci. 2003 Mar;58(3):249-65. doi: 10.1093/gerona/58.3.M249, PMID 12634292.

13. Brudern J, Hallensleben N, Holler I, Spangenberg L, Forkmann T, Rath D. Sleep disturbances predict active suicidal ideation the next day: an ecological momentary assessment study. BMC Psychiatry. 2022 Jan 27;22(1):65. doi: 10.1186/s12888-022-03716-6, PMID 35086519.

14. Wilson S, Argyropoulos S. Antidepressants and sleep: a qualitative review of the literature. Drugs. 2005;65(7):927-47. doi: 10.2165/00003495-200565070-00003, PMID 15892588.

15. Agargun MY, Kara H, Solmaz M. Sleep disturbances and suicidal behavior in patients with major depression. J Clin Psychiatry. 1997 Jun;58(6):249-51. doi: 10.4088/JCP.v58n0602, PMID 9228889.

16. Littlewood DL, Gooding P, Kyle SD, Pratt D, Peters S. Understanding the role of sleep in suicide risk: qualitative interview study. BMJ Open. 2016 Aug 22;6(8):e012113. doi: 10.1136/bmjopen-2016-012113, PMID 27550652.

17. Perlis ML, Grandner MA, Brown GK, Basner M, Chakravorty S, Morales KH. Nocturnal wakefulness as a previously unrecognized risk factor for suicide. J Clin Psychiatry. 2016 Jun;77(6):e726-33. doi: 10.4088/JCP.15m10131, PMID 27337421.

18. Kaplan KA, Harvey AG. Hypersomnia across mood disorders: a review and synthesis. Sleep Med Rev. 2009 Aug;13(4):275-85. doi: 10.1016/j.smrv.2008.09.001, PMID 19269201.

19. Pigeon WR, Hegel M, Unutzer J, Fan MY, Sateia MJ, Lyness JM. Is insomnia a perpetuating factor for late-life depression in the Impact cohort? Sleep. 2008 Apr;31(4):481-8. doi: 10.1093/sleep/31.4.481, PMID 18457235.

20. Taylor DJ. Insomnia and depression. Sleep. 2008 Apr;31(4):447-8. doi: 10.1093/sleep/31.4.447, PMID 18457230.

Published

15-01-2026

How to Cite

ROY, BHASKAR, and PRANAB DAS. “QUALITY OF SLEEP AND ITS RELATIONSHIP WITH DEPRESSIVE SYMPTOMATOLOGY AND SUICIDALITY IN BIPOLAR DEPRESSION”. International Journal of Current Pharmaceutical Research, vol. 18, no. 1, Jan. 2026, pp. 121-5, doi:10.22159/ijcpr.2026v18i1.8051.

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