SYNTHESIS, CHARACTERIZATION AND EVALUATION OF MUCUNA PRURIENS ZINC NANOPARTICLES: INVESTIGATING ANTI-INFLAMMATORY, ANTIOXIDANT, AND ANTI-ARTHRITIC PROPERTIES

GENEVIA FATIMA MERCY V; KARTHIK MOHAN

doi:10.22159/ijms.2025v13i4.54160

Authors

GENEVIA FATIMA MERCY V Department of Biochemistry, E.G.S. Pillay Arts and Science College, Nagapattinam, Tamil Nadu, India
KARTHIK MOHAN Department of Biochemistry, E.G.S. Pillay Arts and Science College, Nagapattinam, Tamil Nadu, India

DOI:

https://doi.org/10.22159/ijms.2025v13i4.54160

Keywords:

anti-inflammatory and anti-arthritic evaluations

Abstract

Objectives: The objective of the study was to synthesize zinc (Zn) nanoparticles (NPs) using Mucuna pruriens extract and evaluate their antioxidant, anti-inflammatory, and anti-arthritic activities through in vitro assays

Methods: Zn NPs were synthesized from M. pruriens and subjected to a series of in vitro biological assays, including 2,2-diphenyl-1-picrylhydrazyl radical scavenging (antioxidant), protein denaturation inhibition, anti-proteinase activity, heat-induced hemolysis, and human red blood cell (HRBC) membrane stabilization methods (anti-inflammatory and anti-arthritic evaluations). Comparisons were made with standard reference drugs

Results: The M. pruriens-derived Zn NPs demonstrated significant antioxidant, anti-inflammatory, and anti-arthritic activities. They effectively inhibited protein denaturation and stabilized red blood cell membranes, often outperforming standard drugs in the tested parameters.

Conclusion: M. pruriens-derived Zn NPs exhibit potent biological activities, highlighting their potential as a natural therapeutic strategy for managing oxidative stress and inflammatory diseases. Further in vitro and preclinical studies are recommended to confirm these findings and explore their clinical applicability.

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