COMPARATIVE STUDY OF VITAMIN B12 DEFICIENCY ASSOCIATED WITH METFORMIN AND METFORMIN IN COMBINATION WITH DPP-4 INHIBITORS IN A TERTIARY CARE HOSPITAL

NABIHA SUBHANI MISBAH; SYEDA AYESHA SIDDIQUA; JUWARIA MASOOD; NASER ASHRAF TADVI; AROOBA FATIMA

doi:10.22159/ijpps.2023v15i10.47818

Authors

NABIHA SUBHANI MISBAH Department of Pharmacology, Government Medical College, Mancherial-504208, Telangana, India https://orcid.org/0000-0003-1029-8069
SYEDA AYESHA SIDDIQUA Department of Pharmacology, Shadan Institute of Medical Sciences, Hyderabad-500008, Telangana, India https://orcid.org/0000-0002-9844-232X
JUWARIA MASOOD Department of Pharmacology, Shadan Institute of Medical Sciences, Hyderabad-500008, Telangana, India
NASER ASHRAF TADVI Department of Pharmacology, Government Medical College, Nalgonda-508001, Telangana, India https://orcid.org/0000-0001-5662-0303
AROOBA FATIMA Shadan Institute of Medical Sciences, Hyderabad-500008, Telangana, India https://orcid.org/0009-0005-4712-5809

DOI:

https://doi.org/10.22159/ijpps.2023v15i10.47818

Keywords:

Type 2 diabetes mellitus, Metformin, DPP-4 inhibitors, Vitamin B12

Abstract

Objective: To estimate the prevalence of vitamin B₁₂ deficiency in type 2 diabetes mellitus patients receiving metformin and metformin in combination with DPP-4 inhibitors. To evaluate the vitamin B₁₂ levels induced by long-term metformin usage.

Methods: It is a retrospective, comparative study of 6 mo, conducted at Shadan Institute of Medical Sciences, Hyderabad. 300 diabetic patients of age group between 30-85 y of either gender were divided into Group-A, receiving metformin and Group-B, receiving metformin+DPP-4 inhibitors. Ethics committee approval was o btained. The baseline and after 6 mo values of Vitamin B₁₂ were noted and analyzed by using SPSS software.

Results: The majority of the patients were from the age group of 56-65 y (n=42, 28%) in Group-A and 46-55 y (n=61, 40.7%) in Group B. Male predominance was observed in both groups (n=81, 54% and n=76, 50.7%). Duration of Diabetes mellitus was ≤5 y in both groups (n=87, 58% and n=112, 74.7%). Vitamin B₁₂ mean values for Group-A (Baseline-478.61, After 6 mo-195.94) and Group-B (Baseline-527.82, After 6 mo-299.05) were obtained. Mean reduction with a statistical significance in both study groups was observed (Group-A-282.66 and Group-B-228.77). Most of the patients showed numbness (14%) in Group-A and general weakness (7.3%) in Group B, respectively.

Conclusion: Type 2 diabetic patients who were on metformin therapy only have a prevalence of vitamin B₁₂ deficiency compared to Metformin in combination with DPP-4 inhibitors receiving patients.

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