PREPARATION AND EVALUATION OF RABEPRAZOLE SODIUM COMPRESSION-COATED TABLETS FOR CHRONOTHERAPY

SARFARAZ MD; VIJAY ARCHAK; H. DODDAYYA

doi:10.22159/ijpps.2025v17i5.53353

Authors

SARFARAZ MD Department of Pharmaceutics, NET Pharmacy College, Raichur-584103, Karnataka, India
VIJAY ARCHAK Department of Pharmaceutics, NET Pharmacy College, Raichur-584103, Karnataka, India
H. DODDAYYA Department of Pharmaceutics, NET Pharmacy College, Raichur-584103, Karnataka, India

DOI:

https://doi.org/10.22159/ijpps.2025v17i5.53353

Keywords:

Rabeprazole sodium, Sodium starch glycolate, Crospovidone, Croscarmellose sodium, HPMC, HPC, Direct compression method

Abstract

Objective: The objective of research work was to prepare and evaluate rabeprazole sodium compression-coated tablets designed for chronotherapy in treating acidity-related disorders, such as peptic ulcer disease and Gastroesophageal Reflux Disease (GERD).

Method: Direct compression method was used to prepare the compression-coated tablets. The formulation process utilized various super disintegrants for core tablets and polymers to create coated tablets that exhibit a pulsatile release profile, ensuring rapid drug release post-lag time. Comprehensive evaluations of the physical properties, hardness, friability, weight variation, drug content, swelling index, disintegration time and in-vitro drug release studies were done for the tablets.

Result: The findings indicated that the developed compression-coated tablets demonstrated optimal mechanical stability, uniformity in drug content, and a desirable release pattern. The optimised formulation C5 achieved 99.85% drug release within 15 mins after 4.15 h of lag time. Kinetic studies revealed a first-order release mechanism, and compatibility assessments via Fourier Transformer Infrared Spectrophotometer (FTIR) confirmed the stability of rabeprazole in the presence of the excipients.

Conclusion: The study highlights the significance of chronomodulated drug delivery systems (CDDS) that can delay drug release for a predetermined duration, aligning with the circadian rhythm of gastrointestinal function. This research provides a promising approach to enhance the therapeutic effectiveness of rabeprazole through a chronotherapeutic strategy developed using compression coating, potentially improving patient outcomes in managing gastric acid-related conditions.

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