BLOCKCHAIN TECHNOLOGY AN INNOVATIVE METHOD WITH REVOLUTIONARY ADVANTAGES AND THREATS FOR THE HEALTHCARE INDUSTRY-A COMPREHENSIVE REVIEW

SANJAY KUMAR GUPTA; FAZLU REHMAN; UTTAM PRASAD PANIGRAHY; AKKI RAJESH

doi:10.22159/ijpps.2025v17i10.53529

Authors

SANJAY KUMAR GUPTA Department of Pharmaceutics, Global College Of Pharmacy Hyderabad, India https://orcid.org/0000-0001-9627-0440
FAZLU REHMAN Department of Pharmaceutical Science, Global College Of Pharmacy, Hyderabad. India https://orcid.org/0009-0002-0427-540X
UTTAM PRASAD PANIGRAHY Faculty of Pharmaceutical Science, Assam down town University, Guwahati, Assam, India-781026 https://orcid.org/0000-0002-8142-044X
AKKI RAJESH Department of Pharmaceutics, Hindu College of Pharmacy, Guntur, (AP), India https://orcid.org/0000-0002-2286-3486

DOI:

https://doi.org/10.22159/ijpps.2025v17i10.53529

Keywords:

Blockchain, Distributed ledger technology, Distributed ledger, Cold chain, Cryptocurrencies

Abstract

Blockchain is a distributed, decentralised ledger system that securely, openly, and irrevocably records and saves data. Blockchain technology is indeed a ground-breaking innovation that is transforming various industries, including the pharmaceutical sector. Blockchain was first created for crypto currencies in order to provide protection against a high risk of fraud and theft while doing away with the necessity for middlemen like banks. The global blockchain technology market in healthcare is experiencing rapid growth, projected to expand from $7.04 billion in 2023 to over $20 billion by 2030. By 2026, blockchain use in India may have risen to a staggering 46%. According to experts, the government intends to create the National Blockchain Portal. This remarkable growth is driven by several key factors, including enhanced data security, streamlined processes, interoperability, regulatory compliance, and the rise of telemedicine. By leveraging blockchain, the pharmaceutical industry could not only streamline operations but also provide higher levels of accountability, improving both safety and trust within the sector. Hospitals, diagnostic labs, pharmacy chains, and other healthcare organisations store and exchange patient data via a blockchain network. Blockchain helps prevent certain risks and provides decentralized safety for healthcare data. From the procurement of raw materials to production, distribution, and delivery, blockchain can monitor every phase of the drug's lifecycle. This ensures that all steps are transparent and auditable, making it harder for counterfeit drugs to enter the market. The Drug Supply Chain Security Act (DSCSA) was enacted into law in 2013 with the goal of safeguarding the integrity of the pharmaceutical supply chain in the US. It focuses on preventing the distribution of stolen, counterfeit, or tainted drugs by establishing requirements for tracing, verification, and product identification. This report explored the technology of blockchain and its notable progress in healthcare.

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References

1. Yuan WX, Yan B, Li W, Hao LY, Yang HM. Blockchain-based medical health record access control scheme with efficient protection mechanism and patient control. Multimed Tools Appl. 2023;82(11):16279-300. doi: 10.1007/s11042-022-14023-3, PMID 36404935.

2. Saini K, Singh JN, editors. Blockchain and IoT approaches for secure electronic health records (EHR). IGI Global; 2024. doi: 10.4018/979-8-3693-1662-7.

3. Haughton O, Campbell C, Howe G, Walcott TH. Evaluating the Integration of Blockchain Technologies in Supply Chain Management: a case study of sustainable fishing International Conference on Computing, Networking, Telecommunications and Engineering Sciences Applications (CoNTESA), Skopje, North Macedonia; 2022. p. 51-6. doi: 10.1109/CoNTESA57046.2022.10011252.

4. Dobbelstein T, Sinemus K, Zielke S. Gamified promotions in shopping apps: the role of regret and its impact on purchase intention 29th Recent Advances in Retailing and Consumer Science Conference; 2023.

5. Sigwart M, Borkowski M, Peise M, Schulte S, Tai S. Blockchain-based data provenance for the internet of things. In: Proceedings of the 9th International Conference on the Internet of Things Bilbao Spain. New York, USA: ACM; 2019. p. 1-8. doi: 10.1145/3365871.3365886.

6. Ali MS, Vecchio M, Pincheira M, Dolui K, Antonelli F, Rehmani MH. Applications of blockchains in the internet of things: a comprehensive survey. IEEE Commun Surv Tutorials. 2019;21(2):1676-717. doi: 10.1109/COMST.2018.2886932.

7. Haleem A, Javaid M, Singh RP, Suman R, Rab S. Blockchain technology applications in healthcare: an overview. International Journal of Intelligent Networks. 2021;2:130-9. doi: 10.1016/j.ijin.2021.09.005.

8. Kuo TT, Kim HE, Ohno Machado L. Blockchain distributed ledger technologies for biomedical and health care applications. J Am Med Inform Assoc. 2017;24(6):1211-20. doi: 10.1093/jamia/ocx068, PMID 29016974.

9. Quinn J, Connolly B. Distributed ledger technology and property registers: displacement or status quo. Law Innov Technol. 2021;13(2):377-97. doi: 10.1080/17579961.2021.1977223.

10. Mozumder MA, Armand TP, Imtiyaj Uddin SM, Athar A, Sumon RI, Hussain A. Metaverse for digital anti-aging healthcare: an overview of potential use cases based on artificial intelligence blockchain IoT technologies its challenges and future directions. Appl Sci. 2023;13(8):5127. doi: 10.3390/app13085127.

11. Abu Elezz I, Hassan A, Nazeemudeen A, Househ M, Abd Alrazaq A. The benefits and threats of blockchain technology in healthcare: a scoping review. Int J Med Inform. 2020 Oct;142:104246. doi: 10.1016/j.ijmedinf.2020.104246, PMID 32828033.

12. Milne AJM, Beckmann A, Kumar P. Cyber-physical trust systems driven by blockchain. IEEE Access. 2020;8:66423-37. doi: 10.1109/ACCESS.2020.2984675.

13. Mikula T, Jacobsen RH. Identity and access management with blockchain in electronic healthcare records 21st Euromicro Conference on Digital System Design (DSD), Prague, Czech Republic; 2018. p. 699-706. doi: 10.1109/DSD.2018.00008.

14. Mazlan AA, Mohd Daud S, Mohd Sam S, Abas H, Abdul Rasid SZ, Yusof MF. Scalability challenges in healthcare blockchain system a systematic review. IEEE Access. 2020;8:23663-73. doi: 10.1109/ACCESS.2020.2969230.

15. Owen R, Mac An Bhaird C, Hussain J, Botelho T. Blockchain and other innovations in entrepreneurial finance: implications for future policy. Strateg Change. 2019;28(1):5-8. doi: 10.1002/jsc.2250.

16. Khordadpour P. Proposed smart 5G framework: incorporating federated learning and transfer learning. TechRxiv. doi: 10.36227/techrxiv.22814831.

17. Ray PP, Dash D, Salah K, Kumar N. Blockchain for IoT-based healthcare: background consensus platforms and use cases. IEEE Syst J. 2021;15(1):85-94. doi: 10.1109/JSYST.2020.2963840.

18. Meit Y. Centre for excellence in blockchain, centre for excellence in blockchain; 2024. Available from: https://blockchain.gov.in/home/home. [Last accessed on 10 Apr 2024].

19. Vyas S, Shukla VK, Gupta S, Prasad A, editors. Blockchain technology: exploring opportunities challenges and applications. Boca Raton: CRC Press; 2022. doi: 10.1201/9781003138082.

20. Blockchain and healthcare: use cases today and opportunities for the future. Available from: www.https.com/blog/blockchain-and-healthcare-use-cases-today-and-in-the-future.

21. Shah B. Remodeling the healthcare industry by employing blockchain technology. 2018 International Conference on Circuits and Systems in Digital Enterprise Technology (ICCSDET). IEEE; 2018. doi: 10.1109/ICCSDET.2018.8821113.

22. Beinke JH, Fitte C, Teuteberg F. Towards a stakeholder-oriented blockchain-based architecture for electronic health records: design science research study. J Med Internet Res. 2019;21(10):e13585. doi: 10.2196/13585, PMID 31593548.

23. Gordon WJ, Catalini C. Blockchain technology for healthcare: facilitating the transition to patient-driven interoperability. Comp Struct Biotechnol J. 2018;16:224-30. doi: 10.1016/j.csbj.2018.06.003, PMID 30069284.

24. Elango V, MM, Vetrivel K, MY, Nikam KD. 3d printing in the pharmaceutical industry: a special consideration on medical device and its applications. Int J Appl Pharm. 2025;17(1):1-11. doi: 10.22159/ijap.2025v17i1.52354.

25. Haq I, Muselemu O. Blockchain technology in pharmaceutical industry to prevent counterfeit drugs. IJCA. 2018;180(25):8-12. doi: 10.5120/ijca2018916579.

26. Kumar R, Wang W, Kumar J, Yang T, Khan A, Ali W. An integration of blockchain and AI for secure data sharing and detection of CT images for the hospitals. Comput Med Imaging Graph. 2021;87:101812. doi: 10.1016/j.compmedimag.2020.101812, PMID 33279761.

27. Ismail L, Materwala H, Hennebelle A. A scoping review of integrated blockchain cloud (BcC) architecture for healthcare: applications challenges and solutions. Sensors (Basel, Switzerland). 2021;21(11):3753. doi: 10.3390/s21113753, PMID 34071449.

28. Kumar R, Marchang N, Tripathi R. Distributed off-chain storage of patient diagnostic reports in healthcare system using IPFS and blockchain International Conference on Communication Systems and Networks (COMSNETS). IEEE; 2020. doi: 10.1109/COMSNETS48256.2020.9027313.

29. Esposito C, De Santis A, Tortora G, Chang H, Choo KK. Blockchain: a panacea for healthcare cloud based data security and privacy? IEEE Cloud Comput. 2018;5(1):31-7. doi: 10.1109/MCC.2018.011791712.

30. Abdellatif AA, Al Marridi AZ, Mohamed A, Erbad A, Chiasserini CF, Refaey A. ssHealth: toward secure blockchain-enabled healthcare systems. IEEE Netw. 2020 Jul-Aug;34(4):312-9. doi: 10.1109/MNET.011.1900553.

31. Nugent T, Upton D, Cimpoesu M. Improving data transparency in clinical trials using blockchain smart contracts. F1000Res. 2016;5:2541. doi: 10.12688/f1000research.9756.1, PMID 28357041.

32. Cohen DJ, Keller SR, Hayes GR, Dorr DA, Ash JS, Sittig DF. Integrating patient generated health data into clinical care settings or clinical decision making: lessons learned from project health design. JMIR Hum Factors. 2016 Oct 19;3(2):e26. doi: 10.2196/humanfactors.5919, PMID 27760726.

33. Maslove DM, Klein J, Brohman K, Martin P. Using blockchain technology to manage clinical trials data: a proof of concept study. JMIR Med Inform. 2018 Dec 21;6(4):e11949. doi: 10.2196/11949, PMID 30578196.

34. Griggs KN, Ossipova O, Kohlios CP, Baccarini AN, Howson EA, Hayajneh T. Healthcare blockchain system using smart contracts for secure automated remote patient monitoring. J Med Syst. 2018 Jun 6;42(7):130. doi: 10.1007/s10916-018-0982-x, PMID 29876661.

35. Ranganthan VP, Dantu R, Paul A, Mears P, Morozov K. A decentralized marketplace application on the Ethereum blockchain 4th International Conference on Collaboration and Internet Computing. IEEE; 2018. p. 90-7. doi: 10.1109/CIC.2018.00023.

36. Bhuvana R, Madhushree LM, Aithal PS. Blockchain as a disruptive technology in healthcare and financial services a review based analysis on current implementations. Int J Appl Eng Manag Lett (IJAEML). 2020;4(1):142-55. doi: 10.5281/zenodo.3822463.

37. Dubovitskaya A, Xu Z, Ryu S, Schumacher M, Wang F. Secure and trustable electronic medical records sharing using blockchain. AMIA Annu Symp Proc. 2017;2017:650-9. PMID 29854130.

38. Gupta SK, Patra S. Development characterization and pharmacokinetic evaluation of optimized vildagliptin sustained release matrix tablet using box-behnken design. Int J App Pharm. 2024;16(1):214-33. doi: 10.22159/ijap.2024v16i1.48052.

39. Rajagopal S, Angamuthu G, Rajagopal S, Angamuthu G, Dhandapani NV. Revolutionizing drug development: how ai and machine learning are shaping the future of medicine a review. Int J App Pharm. 2025 Mar;17(3):148-56. doi: 10.22159/Ijap.2025v17i3.53457.

40. Linn LA, Koo MB. Blockchain for health data and its potential use in health IT and health care-related research. ONC/NIST use of blockchain for healthcare and research workshop. Gaithersburg, MD: ONC/NIST; 2016.

41. Ekblaw A, Azaria A, Halamka JD, Lippman A. A case study for blockchain in healthcare: “MedRec” prototype for electronic health records and medical research data. Use of Blockchain for Healthcare and Research Workshop; 2016.

42. Siyal AA, Junejo AZ, Zawish M, Ahmed K, Khalil A, Soursou G. Applications of blockchain technology in medicine and healthcare: challenges and future perspectives. Cryptography. 2019;3(1):3. doi: 10.3390/cryptography3010003.

43. Zheng X, Sun S, Mukkamala RR, Vatrapu R, Ordieres Mere J. Accelerating health data sharing: a solution based on the internet of things and distributed ledger technologies. J Med Internet Res. 2019;21(6):e13583. doi: 10.2196/13583, PMID 31172963.

44. Dinc R, Ardic N. An evaluation of opportunities and challenges of blockchain technology in healthcare. Br J Hosp Med. 2024;85(11):1-19. doi: 10.12968/hmed.2024.0355.

45. Kassab M, De Franco J, Malas T, Graciano Neto VV, Destefanis G. Blockchain: a panacea for electronic health records? 1st International Workshop on Software Engineering for Healthcare (SEH). IEEE; 2019. doi: 10.1109/SEH.2019.00011.

46. Kuo TT, Gabriel RA, Ohno Machado L. Fair compute loads enabled by blockchain: sharing models by alternating client and server roles. J Am Med Inform Assoc. 2019 May;26(5):392-403. doi: 10.1093/jamia/ocy180, PMID 30892656.

47. Kumar Gupta SK, Patra S. Preparation, characterization and optimization of sustained release matrix tablets of repaglinide using box–behnken design. Res J Pharm Technol. 2023;16(5):2403-10. doi: 10.52711/0974-360X.2023.00396.

48. Rabah K. Challenges and opportunities for blockchain-powered healthcare systems: a review. Mara Res J Med Health Sci. 2017;1(1):45-52.

49. Sarkar S. Blockchain for combating pharmaceutical drug counterfeiting and cold chain distribution. AJRCoS. 2023;16(3):156-66. doi: 10.9734/ajrcos/2023/v16i3353.

50. Dubovitskaya A, Novotny P, Xu Z, Wang F. Applications of blockchain technology for data-sharing in oncology: results from a systematic literature review. Oncology. 2020;98(6):403-11. doi: 10.1159/000504325, PMID 31794967.

51. Justinia T. Blockchain technologies: opportunities for solving real world problems in healthcare and biomedical sciences. Acta Inform Med. 2019;27(4):284-91. doi: 10.5455/aim.2019.27.284-291, PMID 32055097.