APPLICATION OF FILM SPRAY TECHNOLOGY FOR THE ENHANCEMENT OF TRANSDERMAL DRUG DELIVERY SYSTEM- A REVIEW
DOI:
https://doi.org/10.22159/ajpcr.2025v18i5.54003Keywords:
Film-forming spray,, Topical drug delivery, Polymer-based films, Wound healing, Controlled drug release, MucoadhesionAbstract
Conventional topical preparations hold wider utility for various purposes and therapies, yet holds few drawbacks including irritability, lower bio-availability of actives in sites, along with poor local and systemic effects. In current topical research, Film-Forming Sprays, belonging to sprayed solutions, would form a thin film upon contact with wound or open skin, acting as reservoirs for extended release of the active ingredient, like patches, but would confirm contours of skin. On contrast with conventional formulations, film-forming sprays exhibit uniform distribution of drugs and dosages, improved system availability of actives, enhanced penetrability, and ease of administration. This review describes that film-forming sprays contain a number of polymers and excipients that enhance the preparation properties and the stability of the active ingredients. This overview also summarizes the main parameters in the preparation of film-forming sprays such as spray-ability, spread-ability, film characteristics, in addition to the various types of polymeric concentrations, excipients, sprayer types, and evaluations.
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