HESPERIDIN INHIBITS THE ACQUISITION AND EXPRESSION OF SENSITIZATION TO THE LOCOMOTOR STIMULANT EFFECT OF ETHANOL IN SWISS ALBINO MICE
DOI:
https://doi.org/10.22159/ajpcr.2026v19i2.56426Keywords:
Hesperidin, Drug relapse, Ethanol dependence, Locomotor activity, Stimulant Effect of Ethanol, behavioural sensitisationAbstract
Objectives: The objective of the present study was to investigate the influence of hesperidin on both the acquisition (development) and expression (manifestation) of sensitization to ethanol’s locomotor stimulant effects in Swiss albino mice. By examining these parameters, this study aims to elucidate the possible therapeutic role of hesperidin as a natural neuroprotective agent for preventing or attenuating ethanol-induced neurobehavioral adaptations and addiction.
Methods: The presenter search set out to examine the effect of hesperidin on ethanol-induced behavioral sensitization in Swiss albino mice.
Results: The results revealed that treatment with hesperidin across all doses of 4 mg/kg, 8 mg/kg, and 16 mg/kg notably decreased the ethanol-induced count (p<0.05) of locomotion, suggesting a potent inhibitory action of hesperidin on ethanol-induced locomotor sensitization. Hesperidin (8 and 16 mg/kg, i.p.) during development (before each ethanol injection on days 1, 4, 7, and 10) decreased acquisition as well as expression (day 15) of sensitization to locomotor stimulant effect of ethanol. Moreover, chronic administration of hesperidin 30 min before the challenge dose of ethanol (2.0 g/kg, i.p.) produced a dose-dependent attenuation of expression of sensitization to locomotor stimulant effect of ethanol (ethanol-induced locomotor sensitization). Hesperidin per se did not affect locomotor activity. These effects highlight its potential therapeutic role in preventing ethanol addiction or ethanol-triggered behavioral sensitization.
Conclusion: Overall findings suggest that hesperidin may have therapeutic potential to attenuate the ethanol-induced locomotor sensitization which could be due to its neuro-modulatory action, which also suggests its use, as adjuvant for therapy of ethanol addiction. However, future investigations are needed to demonstrate the detailed underlying mechanisms of hesperidin on ethanol addiction.
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