MICRONEEDLES: REVOLUTIONIZING TRANSDERMAL DRUG DELIVERY SYSTEMS
DOI:
https://doi.org/10.22159/ijap.2025v17i3.52517Keywords:
Microneedles, Transdermal drug delivery, Design, Therapeutics, Skin penetration, Minimally invasiveAbstract
Microneedles (MNDs) have emerged as a transformative technology in transdermal drug delivery, offering a minimally invasive alternative to traditional hypodermic needles. These microscale devices allow the direct delivery of medication into the dermal layers by creating tiny punctures in the skin.
This article looks in-depth at the various types of MNDs, including hollow, hydrogel-forming, coated, dissolvable, and solid MNDs, along with the associated manufacturing techniques. These are used in many medical disciplines to reduce side effects, increase patient compliance, and enhance medication efficacy.
Examples of these specialties include pain treatment, hormone administration, vaccine delivery, and cosmetic surgeries. Despite their promising advantages, problems with patient education, regulatory obstacles, and manufacturing scalability need to be fixed.
This article describes the current status of MNDs technology, discusses potential changes in transdermal medication administration, and suggests future directions for study and development.
References
Shahriari MH, Salmani H, Akrami M, Salehi Z. Development of a facile versatile and scalable fabrication approach of solid coated and dissolving microneedle devices for transdermal drug delivery applications. Giant. 2024;18:100284. doi: 10.1016/j.giant.2024.100284.
LV J, Zhao J, LI X, Ling G, Zhang P. Preparation of a novel hyaluronic acid based separable hydrogel microneedle with niacinamide to treat pigment deposition using solvent free solid state crosslinking method. Eur Polym J. 2024;210:113003. doi: 10.1016/j.eurpolymj.2024.113003.
Yang Y, Sheng C, Dong F, Liu S. An integrated wearable differential microneedle array for continuous glucose monitoring in interstitial fluids. Biosens Bioelectron. 2024;256:116280. doi: 10.1016/j.bios.2024.116280, PMID 38603840.
Zhang X, Chen H, Song T, Wang J, Zhao Y. Controllable histotomy based on hierarchical magnetic microneedle array robots. Engineering. 2024;42:166-74. doi: 10.1016/j.eng.2024.05.004.
Zong Q, Wang G, Zhao Z, LI W, Hou MY. Fabrication and characterization of dissolving microneedles for transdermal delivery of hypocrellin A. J Drug Deliv Sci Technol. 2024;95:105594. doi: 10.1016/j.jddst.2024.105594.
Raikar AS, Kalaskar DM, Bhilegaonkar S, Somnache SN, Bodaghi M. Revolutionizing drug delivery by bioinspired 4D transdermal microneedles: advances and future horizons. Eur Polym J. 2024 Apr 24;210:112952. doi: 10.1016/j.eurpolymj.2024.112952.
WU D, WU X, Luan Q, Tang Q, Fan L, Shou X. Dynamic hydrogel integrated microneedle patch with extracellular vesicles encapsulation for wound healing. Chem Eng J. 2024 Aug 1;493:152252. doi: 10.1016/j.cej.2024.152252.
Zhou X, Liu H, YU Z, YU H, Meng D, Zhu L. Direct 3D printing of triple responsive nanocomposite hydrogel microneedles for controllable drug delivery. J Colloid Interface Sci. 2024 Sep 15;670:1-11. doi: 10.1016/j.jcis.2024.05.045, PMID 38749378.
Shahriari MH, Salmani H, Akrami M, Salehi Z. Development of a facile versatile and scalable fabrication approach of solid coated and dissolving microneedle devices for transdermal drug delivery applications. Giant. 2024;18:100284. doi: 10.1016/j.giant.2024.100284.
Yang Y, Sheng C, Dong F, Liu S. An integrated wearable differential microneedle array for continuous glucose monitoring in interstitial fluids. Biosens Bioelectron. 2024;256:116280. doi: 10.1016/j.bios.2024.116280, PMID 38603840.
LV J, Zhao J, LI X, Ling G, Zhang P. Preparation of a novel hyaluronic acid based separable hydrogel microneedle with niacinamide to treat pigment deposition using solvent free solid state crosslinking method. Eur Polym J. 2024 Apr 24;210:113003. doi: 10.1016/j.eurpolymj.2024.113003.
WU D, WU X, Luan Q, Tang Q, Fan L, Shou X. Dynamic hydrogel integrated microneedle patch with extracellular vesicles encapsulation for wound healing. Chem Eng J. 2024 Aug 1;493:152252. doi: 10.1016/j.cej.2024.152252.
Zong Q, Wang G, Zhao Z, LI W, Hou MY. Fabrication and characterization of dissolving microneedles for transdermal delivery of hypocrellin a. J Drug Deliv Sci Technol. 2024 May;95:105594. doi: 10.1016/j.jddst.2024.105594.
Zhou X, Liu H, YU Z, YU H, Meng D, Zhu L. Direct 3D printing of triple-responsive nanocomposite hydrogel microneedles for controllable drug delivery. J Colloid Interface Sci. 2024;670:1-11. doi: 10.1016/j.jcis.2024.05.045, PMID 38749378.
Geng LU, B LI, L Lin, X LI, J Ban. Mechanical strength affecting the penetration in microneedles and PLGA nanoparticle assisted drug delivery importance of preparation and formulation. Biomed Pharmacother. 2024 Apr;173:116339. doi: 10.1016/j.biopha.2024.116339.
Dong CW, Lee CJ, Lee DH, Moon SH, Park WT. Fabrication of barbed microneedle array for bio signal measurement. Sens Actuators A. 2024;367:115040-367. doi: 10.1016/j.sna.2024.115040.
Liang C, Wang R, HE T, Chen D, Zhang G, Yin X. Revolutionizing diabetic wound healing: the power of microneedles. Chin J Plast Reconstr Surg. 2023;5(4):185-94. doi: 10.1016/j.cjprs.2023.12.004.
Biswas AA, Dhondale MR, Singh M, Agrawal AK, Muthudoss P, Mishra B. Development and comparison of machine learning models for in vitro drug permeation prediction from microneedle patch. Eur J Pharm Biopharm. 2024;199:114311. doi: 10.1016/j.ejpb.2024.114311, PMID 38710374.
Kolahi Azar H, Hajian Monfared M, Seraji AA, Nazarnezhad S, Nasiri E, Zeinanloo N. Integration of polysaccharide electrospun nanofibers with microneedle arrays promotes wound regeneration: a review. Int J Biol Macromol. 2024;258(1):128482. doi: 10.1016/j.ijbiomac.2023.128482, PMID 38042326.
Kang J, Kim KY, Kim S, Hong H, Bae BS, Kang SK. A conformable microneedle sensor with photopatternable skin adhesive and gel electrolyte for continuous glucose monitoring. Device. 2023;1(4). doi: 10.1016/j.device.2023.100112.
Ramadon D, Muliawardani F, Nisrina NA, Tri Hamda O, Iswandana R, Wahyuni T. Transdermal delivery of captopril using poly(vinyl pyrrolidone)/poly(vinyl alcohol) based dissolving and hydrogel-forming microneedles: a proof of concept. Eur Polym J. 2024 Mar 25;208:112860. doi: 10.1016/j.eurpolymj.2024.112860.
Ruan S, LI J, Ruan H, Xia Q, Hou X, Wang Z. Microneedle mediated nose to brain drug delivery for improved alzheimers disease treatment. J Control Release. 2024;366:712-31. doi: 10.1016/j.jconrel.2024.01.013, PMID 38219911.
Zhang R, Miao Q, Deng D, WU J, Miao Y, LI Y. Research progress of advanced microneedle drug delivery system and its application in biomedicine. Colloids Surf B Biointerfaces. 2023;226:113302. doi: 10.1016/j.colsurfb.2023.113302, PMID 37086686.
Zhang X, Luo Z, Zhao Y, M LU. Developing hierarchical microneedles for biomedical applications. Engineered Regeneration. 2023 Sep;3(4):316-27. doi: 10.1016/j.engreg.2023.04.004.
Ismail ES, A Mousavi Khaneghah. Advancing food quality assurance: integrating microneedle technology with advanced analytical methods. Nano Today. 2024 Feb;54:102115. doi: 10.1016/j.nantod.2023.102115.
Chen H, Zhou S, Chen J, Zhou J, Fan K, Pan Y. An integrated plant glucose monitoring system based on microneedle enabled electrochemical sensor. Biosens Bioelectron. 2024;248:115964. doi: 10.1016/j.bios.2023.115964, PMID 38160635.
Lammerding LC, Breitkreutz J. Technical evaluation of precisely manufacturing customized microneedle array patches via inkjet drug printing. Int J Pharm. 2023;642:123173. doi: 10.1016/j.ijpharm.2023.123173, PMID 37369288.
Kshirsagar S, Dandekar A, Srivastava RK, Khan J, Muzaffar S, Athar M. Microneedle mediated transdermal delivery of N-acetyl cysteine as a potential antidote for lewisite injury. Int J Pharm. 2023;647:123547. doi: 10.1016/j.ijpharm.2023.123547, PMID 37884214.
Zhang X, Chen H, Song T, Wang J, Zhao Y. Controllable histotomy based on hierarchical magnetic microneedle array robots. Engineering. 2024;42:166-74. doi: 10.1016/j.eng.2024.05.004.
Chen L, Cao P, Zhao P, XU Y, LV G, YU D. Photodynamic controllable microneedle composite with antibacterial antioxidant and angiogenic effects to expedite infected diabetic wound healing. Mater Des. 2024 May;241:112971. doi: 10.1016/j.matdes.2024.112971.
HE M, Jin L, Wang F, Wang X, You Y, HE H. Simple ultrasensitive detection of superoxide anion radical mutations in melanoma mice with SERS microneedles. Spectrochim Acta A Mol Biomol Spectrosc. 2024;316:124292. doi: 10.1016/j.saa.2024.124292, PMID 38669980.
Che QT, Seo JW, Charoensri K, Nguyen MH, Park HJ, Bae H. 4D-printed microneedles from dual sensitive chitosan for non-transdermal drug delivery. Int J Biol Macromol. 2024;261(2):129638. doi: 10.1016/j.ijbiomac.2024.129638, PMID 38266841.
Mulkutkar M, Damani M, Sawarkar S. Polymeric microneedles for the eye: an overview of advances and ocular applications for minimally invasive drug delivery. Eur J Pharm Biopharm. 2024;197:114209. doi: 10.1016/j.ejpb.2024.114209, PMID 38336234.
Sil D, Bhowmik S, Patel P, Balak Das Kurmi. Promising role of microneedles in therapeutic and biomedical applications. J Drug Deliv Sci Technol. 2024 Jan;91:105273. doi: 10.1016/j.jddst.2023.105273.
Babu MR, Vishwas S, Gulati M, Dua K, Singh SK. Harnessing the role of microneedles as sensors: current status and future perspectives. Drug Discov Today. 2024 Jul;29(7):104030. doi: 10.1016/j.drudis.2024.104030.
Chen X, Wang L, YU H, LI C, Feng J, Haq F. Preparation properties and challenges of the microneedles-based insulin delivery system. J Control Release. 2018 Oct 28;288:173-88. doi: 10.1016/j.jconrel.2018.08.042, PMID 30189223.
Chen Z, Ren L, LI J, Yao L, Chen Y, Liu B. Rapid fabrication of microneedles using magnetorheological drawing lithography. Acta Biomater. 2018;283;91-65. doi: 10.1016/j.actbio.2017.10.030.
Maurya A, Nanjappa SH, Honnavar S, Salwa M, Murthy SN. Rapidly dissolving microneedle patches for transdermal iron replenishment therapy. J Pharm Sci. 2018;107(6):1642-7. doi: 10.1016/j.xphs.2018.02.011, PMID 29462631.
Lim DJ, Vines JB, Park H, Lee SH. Microneedles: a versatile strategy for transdermal delivery of biological molecules. Int J Biol Macromol. 2018 Apr 15;110:30-8. doi: 10.1016/j.ijbiomac.2017.12.027, PMID 29223756.
Pere CP, Economidou SN, Lall G, Ziraud C, Boateng JS, Alexander BD. 3D printed microneedles for insulin skin delivery. Int J Pharm. 2018;544(2):425-32. doi: 10.1016/j.ijpharm.2018.03.031, PMID 29555437.
Ronnander P, Simon L, Spilgies H, Koch A. Modelling the in vitro dissolution and release of sumatriptan succinate from polyvinylpyrrolidone based microneedles. Eur J Pharm Sci. 2018;125:54-63. doi: 10.1016/j.ejps.2018.09.010, PMID 30223035.
Ilic T, Savic S, Batinic B, Markovic B, Schmidberger M, Lunter D. Combined use of biocompatible nanoemulsions and solid microneedles to improve transport of a model NSAID across the skin: in vitro and in vivo studies. Eur J Pharm Sci. 2018;125:110-9. doi: 10.1016/j.ejps.2018.09.023, PMID 30287408.
Caudill CL, Perry JL, Tian S, Luft JC, DeSimone JM. Spatially controlled coating of continuous liquid interface production microneedles for transdermal protein delivery. J Control Release. 2018 Aug 28;284:122-32. doi: 10.1016/j.jconrel.2018.05.042, PMID 29894710.
Rzhevskiy AS, Singh TR, Donnelly RF, Anissimov YG. Microneedles as the technique of drug delivery enhancement in diverse organs and tissues. J Control Release. 2018 Jan 28;270:184-202. doi: 10.1016/j.jconrel.2017.11.048, PMID 29203415.
Yan Q, Cheng Z, Liu H, Shan W, Cheng Z, Dai X. Enhancement of Ag85B DNA vaccine immunogenicity against tuberculosis by dissolving microneedles in mice. Vaccine. 2018;36(30):4471-6. doi: 10.1016/j.vaccine.2018.06.025, PMID 29910005.
Ita K. Modulation of transdermal drug delivery with coated microneedles. J Drug Deliv Sci Technol. 2018 Jun;45:203-12. doi: 10.1016/j.jddst.2018.03.021.
Tomono T. A new way to control the internal structure of microneedles: a case of chitosan lactate. Mater Today Chem. 2019;13:79-87. doi: 10.1016/j.mtchem.2019.04.009.
Gholami S, Mohebi MM, Hajizadeh Saffar E, Ghanian MH, Zarkesh I, Baharvand H. Fabrication of microporous inorganic microneedles by centrifugal casting method for transdermal extraction and delivery. Int J Pharm. 2019;558:299-310. doi: 10.1016/j.ijpharm.2018.12.089, PMID 30654056.
Ahmed Saeed AL Japairai K, Mahmood S, Hamed Almurisi S, Reddy Venugopal J, Rebhi Hilles A, Azmana M. Current trends in polymer microneedle for transdermal drug delivery. International Journal of Pharmaceutics. 2020 Sep 25;587:119673. doi: 10.1016/j.ijpharm.2020.119673.
WU M, Zhang Y, Huang H, LI J, Liu H, Guo Z. Assisted 3D printing of microneedle patches for minimally invasive glucose control in diabetes. Mater Sci Eng C Mater Biol Appl. 2020;117:111299. doi: 10.1016/j.msec.2020.111299, PMID 32919660.
Koyani RD. Synthetic polymers for microneedle synthesis: from then to now. J Drug Deliv Sci Technol. 2020 Dec;60:102071. doi: 10.1016/j.jddst.2020.102071.
Azmana M, Mahmood S, Hilles AR, Mandal UK, Saeed Al Japairai KA, Raman S. Transdermal drug delivery system through polymeric microneedle: a recent update. J Drug Deliv Sci Technol. 2020 Dec;60:101877. doi: 10.1016/j.jddst.2020.101877.
Chen L, Ding X, Dong Y, Chen H, Gao F, Cui B. Integration of catalytic hairpin assembly probes into microneedles for detection of microRNA in plants. Sens Actuators B. 2024 Apr 1;404:135277. doi: 10.1016/j.snb.2024.135277.
Khan S, Hasan A, Attar F, Babadaei MM, Zeinabad HA, Salehi M. Diagnostic and drug release systems based on microneedle arrays in breast cancer therapy. J Control Release. 2021 Oct 10;338:341-57. doi: 10.1016/j.jconrel.2021.08.036, PMID 34428480.
Shu W, Heimark H, Bertollo N, Tobin DJ, O Cearbhaill ED, Annaidh AN. Insights into the mechanics of solid conical microneedle array insertion into skin using the finite element method. Acta Biomater. 2021;135:403-13. doi: 10.1016/j.actbio.2021.08.045, PMID 34492370.
Zhang L, Guo R, Wang S, Yang X, Ling G, Zhang P. Fabrication evaluation and applications of dissolving microneedles. International Journal of Pharmaceutics. 2021 Jul 15;604:120749. doi: 10.1016/j.ijpharm.2021.120749.
Radhika C, Gnanavel BK. Buckling analysis of polymer microneedle for transdermal drug delivery. Materials Today: Proceedings. 2021;46:3538-41. doi: 10.1016/j.matpr.2020.12.397.
Sawon MA, Samad MF. Design and optimization of a microneedle with skin insertion analysis for transdermal drug delivery applications. J Drug Deliv Sci Technol. 2021 Jun;63:102477. doi: 10.1016/j.jddst.2021.102477.
DU G, HE P, Zhao J, HE C, Jiang M, Zhang Z. Polymeric microneedle mediated transdermal delivery of melittin for rheumatoid arthritis treatment. J Control Release. 2021;336:537-48. doi: 10.1016/j.jconrel.2021.07.005, PMID 34237400.
Ingrole RS, Azizoglu E, Dul M, Birchall JC, Gill HS, Prausnitz MR. Trends of microneedle technology in the scientific literature patents clinical trials and internet activity. Biomaterials. 2021;267:120491. doi: 10.1016/j.biomaterials.2020.120491, PMID 33217629.
Singh V, Kesharwani P. Recent advances in microneedles based drug delivery device in the diagnosis and treatment of cancer. J Control Release. 2021 Oct 10;338:394-409. doi: 10.1016/j.jconrel.2021.08.054, PMID 34481019.
Glover K, Mishra D, Gade S, Vora LK, WU Y, Paredes AJ. Microneedles for advanced ocular drug delivery. Adv Drug Deliv Rev. 2023 Oct;201:115082. doi: 10.1016/j.addr.2023.115082, PMID 37678648.
Jiang X, Chen P, Niu W, Fang R, Chen H, An Y. Preparation and evaluation of dissolving tofacitinib microneedles for effective management of rheumatoid arthritis. Eur J Pharm Sci. 2023;188:106518. doi: 10.1016/j.ejps.2023.106518, PMID 37419290.
Newell B, Zhan W. Mathematical modelling of microneedle mediated transdermal delivery of drug nanocarriers into skin tissue and circulatory system. J Control Release. 2023 Aug;360:447-67. doi: 10.1016/j.jconrel.2023.07.011, PMID 37429359.
Lin Z, Zheng K, Zhong J, Zheng X. Advances in microneedle based therapy for bone disorders. Biomed Pharmacother. 2023;165:115013. doi: 10.1016/j.biopha.2023.115013, PMID 37531783.
Jose J, Khot KB, Shastry P, Thomas SP, Chopra H, Gopan G. Advances in microneedles based drug delivery system on promoting wound healing. J Drug Deliv Sci Technol. 2023;90:105163. doi: 10.1016/j.jddst.2023.105163.
Ece E, ES I, Inci F. Microneedle technology as a new standpoint in agriculture: treatment and sensing. Materials Today. 2023;68:275-97. doi: 10.1016/j.mattod.2023.07.002.
LI R, Zhang L, Jiang X, LI L, WU S, Yuan X. 3D-printed microneedle arrays for drug delivery. J Control Release. 2022;350:933-48. doi: 10.1016/j.jconrel.2022.08.022, PMID 35977583.
Xiu X, Gao G, Liu Y, MA F. Drug delivery with dissolving microneedles: skin puncture its influencing factors and improvement strategies. J Drug Deliv Sci Technol. 2022;76:103653. doi: 10.1016/j.jddst.2022.103653.
Choi JE, Cha HR, Kim S, Kim JS, Kim MJ, Chung HW. Preparation of particle-attached microneedles using a dry coating process. J Control Release. 2022 Nov;351:1003-16. doi: 10.1016/j.jconrel.2022.10.003, PMID 36216176.
Maru AD, Lahoti SR. Formulation and evaluation of moisturizing cream containing sunflower wax. Int J Pharm Pharm Sci. 2018;10(11):54-9. doi: 10.22159/ijpps.2018v10i11.28645.
Gupta A, Barman S, Roy D. Prescription pattern of antihypertensive medications in patients with hypertension at a Tertiary Care Hospital Assam. Asian J Pharm Clin Res. 2024 Oct;17(10):85-9. doi: 10.22159/ajpcr.2024v17i10.52069.
Bhagyashree N, Veerapaneni K. Correlation between psychological parameters such as depression anxiety and stress and affect score among medical students. Asian J Pharm Clin Res. 2024;17(10)93-4. doi: 10.22159/ajpcr.2024v17i10.52032.
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