FORMULATION AND CHARACTERIZATION OF EFFERVESCENT TABLETS FROM A TRADITIONAL MEDICINE RECIPE FOR DENTAL CARE
DOI:
https://doi.org/10.22159/ijap.2025v17i6.53815Keywords:
Oral disease, Recipe, Formulation, Effervescent mouthwash tabletAbstract
Objective: Plant use to treat pathologies is increasingly common in Africa. Our study focuses on a recipe (active ingredient) of traditional medicine that has proven itself in treating dental caries and oral pathologies. This study aims to formulate and evaluate the quality of effervescent tablets based on the recipe (active ingredient) for treating dental caries and oral hygiene.
Methods: A physicochemical and pharmacotechnical characterization of the recipe (RMC, pH, Hausner index, Carr index, flow rate) was carried out. Five stoichiometric ratios of the citric acid/sodium bicarbonate combination were used (1:3.32; 1:3.11; 1:3; 1:2.93; 1:2.87). The tablets were obtained after wet granulation. Pharmacotechnical tests were carried out according to the European Pharmacopoeia 10th Ed to determine the most optimal formulation that could promote rapid release of the active ingredient.
Results: The recipe constituting the active ingredient has properties with an apparent density of 0.50, and a density after tamping of 0.65. The compressibility index is 23.61, and the Hausner index is 1.30. These fairly weak rheological properties required improvement through granulation. A total of 5 formulations were obtained. Formulations F2 to F5 had a disintegration time of less than 5 min. The friability rate was less than 4.60%, 0.86%, 0.91%, 0.75%, and 1.22 for the formulations respectively F1 to F5 and the hardness 95N, 81.8N, 118N, 103.6N, 89.8N. The stoichiometric ratio of 1:3.11 gave us the most optimal formulation with a disintegration time of 156 seconds, a friability rate of 0.86%, and a pH of 5.13.
Conclusion: These results demonstrate the feasibility of a solid form to be redispersed for use in oral hygiene.
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Copyright (c) 2025 Boladé Constantin ATCHADE, Salfo OUEDRAOGO, Tata Kadiatou TRAORE, Isanorelle BONOU-SELEGBE, Aimé-Césaire AYENA, Mory GUILAO, Josias B.G YAMEOGO, Bavouma Charles SOMBIE, Hermine Zime DIAWARA, Rasmané SEMDE
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