EFFERVESCENT TABLET FORMULATION OF TURMERIC EXTRACT (CURCUMA DOMESTICA) WITH ARTOCARPUS HETEROPHYLLUS SEED STRACH AS A BINDER AND SIRAITIA GROSVENORII AS A SWEETENER

MOCHAMAD LUQNI MAULANA; MUHAMMAD ALFIAN; NURUL FAIZAH

doi:10.22159/ijap.2025.v17s1.14

Authors

MOCHAMAD LUQNI MAULANA Departement of Pharmacy, Faculty of Halal Industry, Universitas Nahdlatul Ulama Yogyakarta, Sleman-55293, Yogyakarta, Indonesia https://orcid.org/0009-0003-6519-6809
MUHAMMAD ALFIAN Departement of Pharmacy, Faculty of Halal Industry, Universitas Nahdlatul Ulama Yogyakarta, Sleman-55293, Yogyakarta, Indonesia https://orcid.org/0000-0002-6884-7625
NURUL FAIZAH Departement of Pharmacy, Faculty of Halal Industry, Universitas Nahdlatul Ulama Yogyakarta, Sleman-55293, Yogyakarta, Indonesia https://orcid.org/0009-0003-0852-9769

DOI:

https://doi.org/10.22159/ijap.2025.v17s1.14

Keywords:

Effervescent tablet, Turmeric extract, Artocarpus heterophyllus seed starch, Siraitia grosvenorii

Abstract

Objective: The appropriate processing of natural ingredients, such as turmeric, into forms that are well-received by the public is anticipated to enhance practicality and public interest. One approach involves incorporating natural ingredients, like Artocarpus heterophyllus seed starch as a binder and Siraitia grosvenorii as a sweetener, into turmeric extract effervescent tablets.

Methods: Turmeric extract is formulated into three different groups: K(-) negative group without binders and sweeteners, K(+) positive group with PVP and aspartame, F1 (Formula 1), F2 (Formula 2), and F3 (Formula 3) with varying proportions of jackfruit seed starch and lo han kuo granules (3:15%, 5:25%, and 7:35%). Effervescent tablets are produced using the wet granulation method. Each formulation undergoes physical evaluation tests for the granules, including for moisture, flow time, angle of repose, and compressibility. Following this, the physical properties of the effervescent tablets are evaluated for weight uniformity, size uniformity, hardness, friability, dissolution time, pH, dissolution, curcumin content, and hedonic aspects with the use of statistical tests.

Results: The turmeric extract contained 76.44% curcumin. Different concentration of Artocarpus heterophyllus seed starch had a significant impact (p<0.05) on enhancing various characteristics of effervescent granules, including the angle of repose, compressibility, weight uniformity, hardness, and dissolution time of effervescent tablets. However, these variations did not significantly affect (p>0.05) the moisture test, effervescent granule flow time, uniformity of size, pH, dissolution, and curcumin content in effervescent tablets.

Conclusion: F3 is the ideal formula for testing the physical properties of granules and effervescent tablets. It is the most preferred due to its color, aroma, and taste.

References

Nuzul ZR, Anwar C, Husna A, Maisurah. Relationship of knowledge of Gegenerative of degenerative disease with the implementation of a healthty living community movement programs (GERMAS) Bhayangkara Hospital Banda Aceh City. J Heal Technol Med. 2022;8(2):1027-35.

Wahyuningtyas SE, Permana ID, Wiadnyani AA. The effect of the kinds of solvent to curcumin content and antioxidant activity of the extract turmeric (Curcuma domestica Val.). ITEPA. 2017;6(2):61–70. Available from: https://ojs.unud.ac.id/index.php/itepa/article/view/36950/22387. [Last accessed on 13 Jan 2025].

Ardana T, Yuandani, Satria D, Lux Putra ED, Muhammad M, Rosidah. Acute toxicity evaluation of curcuma domestica vahl. rhizome vco curcuminoid extract. Int J App Pharm. 2024;16:44-51. doi: 10.22159/ijap.2024v16s4.52268.

Akter J, Hossain MA, Takara K, Islam MZ, Hou DX. Antioxidant activity of different species and varieties of turmeric (Curcuma spp): isolation of active compounds. Comp Biochem Physiol C Toxicol Pharmacol. 2019;215:9-17. doi: 10.1016/j.cbpc.2018.09.002, PMID 30266519.

Sudjarwo S, Bobsaid J, Windianto FR, Rizkyah C, Shaffiqa N, Putra AS. Improving the bioavailability of curcumin in curcuma heyneana by preparing solid dispersion. BIKFAR. 2023;10(1):23-7. doi: 10.20473/bikfar.v10i1.44546.

Majee SB, Mishra T, Gupti S. Gastroretentive effervescent floating tablets (Greft) of drugs acting on cardiovascular diseases. Int J Pharm Pharm Sci. 2024;16(7):21-7. doi: 10.22159/ijpps.2024v16i7.51296.

Anwar K. Formulation of turmeric (Curcuma domestica Val.) extract effervescent tablet with amount variation of citric acid-tartaric acid as acid source. Pharm Study Program FMIPA Unlam. 2011;44(8):168-78.

Gong X, Chen N, Ren K, Jia J, Wei K, Zhang L. The fruits of Siraitia grosvenorii: a review of a Chinese food-medicine. Front Pharmacol. 2019;10:1400. doi: 10.3389/fphar.2019.01400, PMID 31849659.

Pandey AK, Chauhan OP. Monk fruit (Siraitia grosvenorii)-health aspects and food applications. Pantnagar J Res. 2019;17(3):191-8.

Sari NW, Nurcahyo H, Santoso J. The effect of jackfruit seed starch binding concentration (Artocarpus heterophyllus Lamk.) on effervescent granule preparation formulation. J Ilm Farm. 2021;X(X):1-10.

Nikmah LM, Fajariyah S, Mahriani. Effect of ethanol extract of turmeric rhizome (Curcuma longa) on the histological structure of the rectum of white rats (Rattus norvegicus) induced by dextran sodium sulphate (DSS). J Ilmu Dasar. 2019;20(1):13-8.

Alfian M, Hasanudin MN, Maulana ML, Mustainin M. In vitro test of sunscreen activity of turmeric extract and lotion (Curcuma domestica Val.) using UV-vis spectrophotometer. J Ilm Ibnu Sina. 2024;9(1):78-88.

Musiam S, Alfian R. Validation of uv spectrophotometry method in analysis of mefenamic acid levels determination in generic tablet preparations. J Ilm Ibnu Sina. 2017;2(1):31-43.

Nadendla RR, Mounika M, Ranjithadubba VS, Jahnavi M, VSP, Yakshithayarra SP. Development and verification of uv spectrophotometric technique for determining N-acetylcysteine in tablet formulations. Int J Pharm Pharm Sci. 2024;16(10):30-5. doi: 10.22159/ijpps.2024v16i10.51004.

Sugiandi S, Afriani K, Hamidi A, Maulia G. The effect of solvents and extract types on curcumin levels in turmeric and Javanese ginger simples by visible light spectrophotometry. War Akab. 2021;45(2):6-11. doi: 10.55075/wa.v45i2.48.

Rosa Y, Alwi M, Ramadoni P. Potential of pregelatinated starch from jackfruit seeds as a disintegrator in the manufacturing of paracetamol tablets by direct compression method. J Kesehat J Ilm Multi Sci. 2020;X(1):67-76.

Gazali G. Activity of lo han kuo (Siraitia grosvenorii) fruit infusion on the biofilm formation of-candida albicans ATCC 10231' Skripsi; 2020. Available from: http://repository.wima.ac.id/22658.

Zuraidah N, WD Ayu, A Mirhansyah. The effect of variations in citric acid and tartaric acid concentrations on the physical properties of effervescent granules from jackfruit leaf extract (Artocarpus heterophyllus L.). Proceeding Mulawarman Pharm Conf. 2018;8:48-56. doi: 10.25026/mpc.v8i1.302.

Oktavina WR, Imtihani HN. Formulasi dan evaluasi suspensi granul effervescent ekstrak kitosan cangkang kepiting bakau (Scylla serrata) dengan perbandingan natrium bikarbonat. J Islamic Pharm. 2023;8(2):62-7. doi: 10.18860/jip.v8i2.23533.

Salmatuzzahro A, Nawangsari D, Fitriana AS. Physical properties test of effervescent tablets from banana peel extract (musa X paradisiaca L) with a comparison of citric acid and sodium bicarbonate. Skripsi. 2022.

Haryono IA, Noval N. Formulasi dan evaluasi tablet effervescent dari ekstrak buah tampoi (Baccaurea macrocarpa). J Surya Medika. 2022;7(2):34-44. doi: 10.33084/jsm.v7i2.3201.

Sagala RJ, Rachmawati P, Kambira PF. ‘Literature study of ingredients affecting dissolution time of herbal effervescent tablets. JFI. 2021;13(2):174-84. doi: 10.35617/jfionline.v13i2.44.

Mayefis D, Bidriah M. Formulasi sediaan tablet effervescent ekstrak herbal meniran (Phyllantus niruri L) dengan variasi konsentrasi sumber asam dan basa. Ahmar Metastasis Health J. 2022;2(2):75-86. doi: 10.53770/amhj.v2i2.122.

Puspita OE, Ebtavanny TG, Fabyoke AF. Study of the effect of binder types of turmeric solid dispersion tablet preparations on the dissolution profile of turmeric extract (Curcuma domestica). Pharm J Indones. 2022;8(1):95-102. doi: 10.21776/ub.pji.2022.008.01.10.

Sari LO, Berlianti T, Irawan ED. Formula optimization of effervescent tablet of meloxicam solid dispersion using factorial design. Pustaka Kesehat. 2018;6(2):225. doi: 10.19184/pk.v6i2.7571.

Praponco H. Formulation and physical properties of effervescent tablet from combinations of coffee extracts (Coffea. Sp) and cinnamon wood extracts (Cinnamomum Burmannii) with citric acid variations as sources acid coffee. Karya Tulis Ilmiah, Politek. Harapan Bersama Tegal; 2019.

Handayani R, Syaqib N, Najihudin A. Evaluation of effervescent granules from various extracts. Parapemikir J Ilm Farm. 2021;10(1):17. doi: 10.30591/pjif.v10i1.2095.

Cheiya IV, Rusli R, Fitriani N. Pemanfaatan limbah pati kulit pisang (Musa paradisiaca) sebagai bahan pengikat granul parasetamol dengan metode granulasi basah. J Sains Kes. 2023;5(1):44-9. doi: 10.25026/jsk.v5i1.1606.

Zulfa E, Prihantini M. Paracetamol tablet formulation with starch binder of Gembili tuber (Dioscorea esculenta L.). J Pharmascience. 2019;6(2):55. doi: 10.20527/jps.v6i2.7351.

Juweira A, Ratnamala KV. Formulation and evaluation of sintered gastroretentive tablets of pioglitazone using design of experiment. Int J Pharm Sci Rev Res. 2021;69(1). doi: 10.47583/ijpsrr.2021.v69i01.007.

Adiari NK, Putra IG. Article review: the effect of variation in binder concentration in the formulation of antibacterial lozenges from natural ingredients on the physical properties of the preparation. In: Proceedings of the Natl Pharm Work. Semin. 2023;2:580-92. doi: 10.24843/wsnf.2022.v02.p46.

Rijal M, Buang A, Prayitno S. The effect of PVP K-30 concentration as a binder on the physical quality of tekelan leaf extract tablets (Chromolaena odorata. (L.). J Kesehat Yamasi Makasar. 2022;6(1):98-111.

Laili N, Komala AM, Maulida H, Suprapto S. Optimasi konsentrasi amylum sagu (Metroxylon rumphii) sebagai co-processed pada pembuatan tablet teofilin. Pharmacon. 2019;14(2):72-80. doi: 10.23917/pharmacon.v14i2.6422.

Apriyanto BH, Rusli R, Rahmadani A. Evaluation of taro starch (Colocasia esculenta Schott) as a filler in paracetamol tablet preparations. Proceeding Mulawarman Pharm Conf. 2017;5:69-79. doi: 10.25026/mpc.v5i1.222.

Ainurofiq A, Azizah N. Comparison of the use of intragranular, extragranular and combination disintegrants. J Pharm Sci Clin Res. 2016;1:1-9.

Yulia M, Wulandari Y. Effervescent powder formulation of Kundur fruit extract (Benincasa hispida (Thunb.) Cogn.) with sodium bicarbonate variations. SITAWA J Farm Sains Obat Tradis. 2022;1(2):41-9. doi: 10.62018/sitawa.v1i2.6.

Octavia DR, Nurafifah D, Muhtaromah, Utami PR. Formulation and hedonic test of turmeric extract effervescent powder with variations of citric acid and tartaric acid. Wind Heal J Kesehat. 2021;4(4):348-57.

Ansar. Influence of temperature and relative humidity on the quality of fruit juice effervesent tablet during storage. Teknol Ind Pangan. 2011;XXII(1):73-7.

Munir MB. Formulation of effervescent tablet containing curcuma xanthorrhiza roxb. Extract curcuma. Skripsi; 2012.

Peram MR, Jalalpure SS, Palkar MB, Diwan PV. Stability studies of pure and mixture form of curcuminoids by reverse phase-HPLC method under various experimental stress conditions. Food Sci Biotechnol. 2017;26(3):591-602. doi: 10.1007/s10068-017-0087-1, PMID 30263583.