AN OVERVIEW OF BILAYER TABLET TECHNOLOGY: DESIGN, MANUFACTURING, AND THERAPEUTIC APPLICATIONS

VEERENDRA UMESH DHOKE; SHUBHAM S. GUPTA; BHAGYASHRI R. DHAKATE; RAKSHA PUROHIT; PRIYANKA A. MANDAL; SHUBHAM KAMBLE; GULSHAN GURUNANI

doi:10.22159/ijap.2025v17i6.54542

Authors

VEERENDRA UMESH DHOKE Department of Pharmaceutics, the Royal Gondwana College of Pharmacy Nagpur, Maharashtra, India https://orcid.org/0009-0003-3414-2795
SHUBHAM S. GUPTA Department of Pharmaceutical Sciences, Gurunanak College of Pharmacy, Nagpur, Maharashtra, India https://orcid.org/0000-0003-0501-5116
BHAGYASHRI R. DHAKATE Department of Pharmaceutics, National College of Pharmacy, Nagpur, Maharashtra, India https://orcid.org/0009-0009-2311-926X
RAKSHA PUROHIT Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Nagpur, Maharashtra, India https://orcid.org/0009-0005-0707-0575
PRIYANKA A. MANDAL Department of Pharmaceutics, Siddhivinayak College of Pharmacy, Warora, Maharashtra, India https://orcid.org/0009-0000-6121-6989
SHUBHAM KAMBLE Department of Pharmaceutics the Royal Gondwana College of Pharmacy, Nagpur, Maharashtra, India https://orcid.org/0009-0008-9764-9151
GULSHAN GURUNANI Pharmaceutical Chemistry, Gurunanak College of Pharmacy, Nagpur, Maharastra, India https://orcid.org/0000-0002-3026-7828

DOI:

https://doi.org/10.22159/ijap.2025v17i6.54542

Keywords:

Bilayer tablets, Controlled release, Combination therapy, Formulation strategies, Regulatory considerations

Abstract

Bilayer tablets are innovative drug delivery systems designed to enhance therapeutic efficacy by enabling the simultaneous or sequential release of active pharmaceutical ingredients. They offer distinct advantages in managing diseases requiring combination therapy or controlled release. This system enables the incorporation of two different drugs or release profiles within a single unit, enhancing patient compliance and therapeutic outcomes. Bilayer tablets are particularly beneficial for drugs with narrow therapeutic windows, those requiring sustained release, or those with poor bioavailability. This review outlines the formulation strategies, types of bilayer tablets, manufacturing challenges, evaluation parameters, and current regulatory considerations.

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