SYNTHESIS AND OPTIMIZATION OF MAGNESIUM ALUMINOMETASILICATE-TEMPLATED MESOPOROUS NANOPARTICLES FOR CANNABIDIOL DELIVERY: A NOVEL APPROACH

PARE PANKAJ RAJENDRA; MANISH KUMAR

doi:10.22159/ijap.2025v17i6.55307

Authors

PARE PANKAJ RAJENDRA Department of Pharmaceutics, Madhav University, Pindwara, Rajasthan, India https://orcid.org/0009-0004-3907-0679
MANISH KUMAR Department of Pharmaceutics, Madhav University, Pindwara, Rajasthan, India https://orcid.org/0000-0001-6022-7782

DOI:

https://doi.org/10.22159/ijap.2025v17i6.55307

Keywords:

Cannabidiol (CBD), Mesoporous nanoparticles (MNPs), Magnesium Aluminometasilicate (MAS), Drug delivery, Solubility enhancement, Sustained release, Box-behnken design (BBD), Analysis of variance (ANOVA)

Abstract

Objective: Mesoporous nanoparticles (MNPs) have improved practically insoluble drugs' bioavailability and therapeutic efficacy. Novel Magnesium Aluminometasilicate (MAS)-templated synthesis of cannabinoid-loaded mesoporous nanoparticles: Formulation, characterization, and in vitro drug release assessment.

Methods: The purity and thermal stability of cannabidiol (CBD) were evaluated by melting point and differential scanning calorimetry analyses. The effects of Magnesium Aluminometasilicate (MAS), triethanolamine, and temperature on entrapment efficiency and particle size were assessed using a Box-Behnken Design (BBD) to optimize the formulation. Scanning Electron Microscopy (SEM), zeta potential, and Polydispersity Index (PDI) were used to analyze the formulation. In vitro drug release and stability studies were conducted.

Results: The calibration curve showed linear relationship (R² = 0.9984). Highest solubility was observed in DMSO (60.54±2.47 mg/ml), while phosphate buffer pH 6.8 showed limited solubility (0.31±0.03 mg/ml). Formulation F13 demonstrated optimal entrapment efficiency (87.7%), loading capacity (37.24%), particle size (128.6 nm), and PDI (0.245). Zeta potential (-23.9 mV) confirmed colloidal stability. Release kinetics followed zero-order model (R² = 0.9863) with sustained release (94.04% over 12 h). Accelerated stability studies confirmed excellent stability over six months.

Conclusion: The study demonstrates that magnesium aluminometasilicate template-assisted encapsulation of cannabidiol achieved high entrapment efficiency (87.7%), sustained in vitro release (94.04% over 12 h), and excellent stability under accelerated conditions. In vivo bioavailability studies are required to confirm therapeutic potential.

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