COMPARATIVE STUDY ON THERAPEUTIC EFFICACY OF MINOXIDIL AND PLATELET-RICH PLASMA EXOSOME IN ANDROGENETIC ALOPECIA MICE MODELS

NURRACHMAT MULIANTO; INDAH JULIANTO; MUHAMMAD EKO IRAWANTO; NUGROHOAJI DHARMAWAN; PRISTIA WIDYA MONICA; TRYA OKTAVIANI

doi:10.22159/ijap.2025.v17s2.13

Authors

NURRACHMAT MULIANTO Department of Dermatology and Venerology of Dr. Moewardi General Hospital/Sebelas Maret University, Surakarta, Indonesia
INDAH JULIANTO Department of Dermatology and Venerology of Dr. Moewardi General Hospital/Sebelas Maret University, Surakarta, Indonesia. Dermama Biotechnology Laboratorium, Surakarta, Indonesia
MUHAMMAD EKO IRAWANTO 1Department of Dermatology and Venerology of Dr. Moewardi General Hospital/Sebelas Maret University, Surakarta, Indonesia
NUGROHOAJI DHARMAWAN 1Department of Dermatology and Venerology of Dr. Moewardi General Hospital/Sebelas Maret University, Surakarta, Indonesia https://orcid.org/0000-0003-3106-5598
PRISTIA WIDYA MONICA Department of Dermatology and Venerology of Dr. Moewardi General Hospital/Sebelas Maret University, Surakarta, Indonesia https://orcid.org/0000-0001-9864-723X
TRYA OKTAVIANI Department of Dermatology and Venerology of Dr. Moewardi General Hospital/Sebelas Maret University, Surakarta, Indonesia

DOI:

https://doi.org/10.22159/ijap.2025.v17s2.13

Keywords:

Androgenetic alopecia, Platelet-rich plasma exosome, Minoxidil, Hair follicle density, Anagen: telogen ratio

Abstract

Objective: Androgenetic alopecia (AGA) is a common type of hair loss worldwide. Currently, available treatment options for AGA show inconsistent results and may cause various undesirable side effects. Platelet-rich plasma exosomes (PRP-Exo) is one of the therapeutic modalities that has shown satisfactory results to treat hair loss. This study aims to assess the effectiveness of minoxidil and PRP-Exo for AGA.

Methods: An experimental investigation was conducted using alopecia BALB/c mice to examine hair follicle characteristics. Fourteen mice were divided into two groups, one group received daily topical application of 5% minoxidil, meanwhile, the other group received 0.1 ml injections of PRP-Exo on days 11, 18 and 25. Follicle density and the anagen: telogen ratio were evaluated histopathological.

Results: The administration of PRP-Exo resulted in significantly different follicle density (68.61±7.64 vs. 40.14±11.60; p = 0.007) and anagen: telogen ratio (0.34±0.04 vs. 0.22±0.02; p = 0.009) compared to minoxidil.

Conclusion: This investigation demonstrates that PRP-Exo effectively enhance both hair follicle density and the anagen: telogen ratio in the AGA mice model when compared to minoxidil 5%.

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