OPTIMISATION AND CHARACTERIZATION OF TERBINAFINE-LOADED TOPICAL SOLID LIPID NANOPARTICLES
DOI:
https://doi.org/10.22159/ijap.2026v18i2.56153Keywords:
Solid lipid nanoparticles, Terbinafine, Glyceryl monostearate, Precirol ATO5, DoE, FTIRAbstract
Objective: The present study aimed to prepare a nanoformulation using GMS and/or Precirol ATO5and Tween 80 (1% and 2%) to develop and optimize solid lipid nanoparticles with the potential to enhance oral bioavailability.
Methods: The factorial design was selected to study the impact of two solid lipid formulation parameters on the particle size (PS), zeta potential (PS), entrapment efficiency (EE), and in vitro drug release. The emulsification technique was used to develop solid lipid nanoparticles, and the prepared nanoparticles were evaluated using design of expert (DoE) software.
Results: The drug estimation was found linear between 5 and 40µg/ml, and the melting point was found to be 195 °C. Enhancing the lipid content (GMS or precirol ATO5) resulted in an increase in PS. However, increasing the concentration of the surfactant (Tween 80) reduced the PS. Among the two lipids used as a qualitative factor, the desirability function was more with precirol ATO5 formulations. The numerical optimization suggested an optimized formulation containing 2% Tween 80 and 5.5% precirol ATO5. Among the experimental batches, formulation F6 (2% Tween 80 and 3% precirol ATO5) exhibited a PS of 98.3±5.12 nm, an EE of 81.5±6.27%, and a drug release of 77.5±8.09% over 10 h.
Conclusion: The TB-loaded SLN were successfully formulated by the emulsification method. Among the two lipids used as a qualitative factor, the desirability function was more with precirol ATO5 formulations. This may potentially enhance oral bioavailability, as suggested by nanoscale PS and improved in vitro drug release.
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Copyright (c) 2026 DIVYA KARUPPAIAH, RAJKUMAR KARUNAKARAN, AYYAPPAN THIYAGARAJAN, JAMAL MOIDEEN MUTHU MOHAMED, KRISHNA PRABHA NADUCHAMY
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