EVALUATION OF ORGAHEALTM TURMERIC CURCUMIN WITH BOSWELLIA, GINGER AND BLACK PEPPER CAPLET ROLE IN MODULATING INFLAMMATION AND JOINT FUNCTION

Abstract

Objective: This study evaluated the antioxidant, anti-inflammatory, and anti-arthritic properties of the Orgaheal^TM Turmeric curcumin with Boswellia (boswellic acids), ginger (gingerols), and black pepper (piperine) caplet (OTC).

Methods: Antioxidant activity was assessed using standard assays, while anti-inflammatory effects were tested via protein denaturation models. Cell viability, (NO) production, cytokine levels (IL-10, IL-6, TNF-α), reactive oxygen species (ROS), and endogenous antioxidant enzyme activity were evaluated in RAW 264.7 and SW982 cell lines. Statistical significance was set at p<0.05.

Results: TAE exhibited significant antioxidant activity, effectively scavenging radicals and inhibiting lipid peroxidation. It inhibited protein denaturation with IC50 values of 2.76 mg/ml (BSA) and 2.73 mg/ml (egg albumin). In RAW 264.7 cells, TAE maintained viability up to 50 µg/ml, reduced NO production, and restored antioxidant enzyme activity. In SW982 cells, it reduced IL-1β-induced ROS, improved antioxidant levels, and demonstrated anti-arthritic potential by decreasing TNF-α and IL-6 while increasing IL-10.

Conclusion: Orgaheal^TM Turmeric curcumin with boswellic acids, gingerols, and piperine caplet (OTC), demonstrates significant antioxidant, anti-inflammatory, and anti-arthritic properties. These findings suggest its potential as a complementary therapeutic agent for managing oxidative stress, inflammation, and arthritis-related conditions, offering a natural alternative for chronic inflammatory disease management.